A Review of Gender Differences in Studies of Thyroid Function and Major Depression

2002 ◽  
Vol 32 (8) ◽  
pp. 477-482 ◽  
Author(s):  
Glenda M MacQueen ◽  
Russell T Joffe
Author(s):  
Tushar Agravat

Background and Aim: Major depression in both women and men is a debilitating disorder that disrupts relationship and daily lives and affects nearly 10% of general populations. The aims and objectives of this study were to determine the gender differences in major depression with respect to following: Demographic characteristics, Clinical manifestations, Stressful life events, Risk factors. Materials and Methods: Total of 100 patients was included in the study. All the included patients meet the criteria for DSM-IV (Diagnostic and Statistical Manual of Mental Disorders) diagnosis of major depression. The included patients were interviewed at the department of Psychiatry, B. J. Medical College & civil hospital Ahmedabad. Based on the Life Events Scale by Holmes and Rahe (1967), its Indian adaptation PSLE (Presumptive stressful life events scale) was done by Gurmeet Singh (1983). The statistical analysis was done by using SPSS IX version. Results: Their ages range from 18 to 70 years. Most of the patients were married, were from urban background, and nuclear family. On Hamilton Depression rating scale when the statistical analysis was done, there was no significant difference between males and females. Men had higher mean life events score than women but this was not statistically significant. In female, there was significant positive correlation between number of life events in one year and severity of depression as well as impact score during one year prior to onset of depression and Hamilton rating scores. Conclusion: Male and female major depression patients did not differ as regards demographic characteristics, except that most women were homemakers and men were employed. Number of stressful life events experienced during 1 year prior to onset of MDD was similar. Early insomnia, middle insomnia and somatic symptoms general were more severely present in female patients.


2009 ◽  
Vol 195 (5) ◽  
pp. 459-460 ◽  
Author(s):  
Chia-Ming Chang ◽  
Shih-Cheng Liao ◽  
Hung-Chi Chiang ◽  
Ying-Yeh Chen ◽  
Kwan-Cho Tseng ◽  
...  

SummaryAll suicides (n=12 497) in Taiwan in 2001–2004 were identified from mortality records retrieved from the National Health Insurance Database. Altogether, 95.1% of females and 84.9% of males had been in contact with healthcare services in the year before their death. Females received significantly more diagnoses of psychiatric disorders (48.0% v. 30.2%) and major depression (17.8% v. 7.4%) than males. Such differences were consistent across different medical settings where contact with hospital-based non-psychiatric physicians was as common as with general practitioners (GPs). However, diagnoses of psychiatric disorders were underdiagnosed in both genders.


2004 ◽  
Vol 4 (1) ◽  
Author(s):  
Konstantinos N Fountoulakis ◽  
Apostolos Iacovides ◽  
Philippos Grammaticos ◽  
George St Kaprinis ◽  
Per Bech

1998 ◽  
Vol 43 (8) ◽  
pp. S98 ◽  
Author(s):  
Z. Kronfol ◽  
V.K. Singh ◽  
J. Boura ◽  
M.B. Brown

2003 ◽  
Vol 33 (5) ◽  
pp. 927-931 ◽  
Author(s):  
V. A. SANATHARA ◽  
C. O. GARDNER ◽  
C. A. PRESCOTT ◽  
K. S. KENDLER

Background. Although prior research has demonstrated a strong association between interpersonal dependency (IPD) levels and risk for major depression (MD), the possible aetiological explanations of this association as well as any gender differences in the IPD–MD relationship need further clarification.Method. Population-based twin samples (N=7174) were interviewed in multiple waves to assess IPD and MD as part of a larger twin study. IPD levels were assessed using the Interpersonal Dependency Inventory while MD diagnoses were derived from the SCID. Cox proportional hazard models and multiple regression techniques were utilized.Results. IPD was strongly associated with a risk for lifetime MD. Pre-morbid IPD scores were predictive of future onsets of MD while experiencing a MD episode was also associated with a significant rise in IPD levels. While females had higher IPD scores, IPD scores were more significantly associated with risk for lifetime MD in males. Controlling for the level of IPD substantially reduced the observed association between gender and risk for MD.Conclusion. The strong association observed between IPD and risk for MD results largely from IPD being a risk factor for MD, but state effects of MD on IPD also contribute. IPD scores in males were more predictive of lifetime MD than for females. The higher levels of IPD in women than in men may contribute meaningfully to the sex differences in risk for MD.


2020 ◽  
Vol 66 (5) ◽  
pp. 424-430
Author(s):  
HIROKO SHUKUZAWA ◽  
HAJIME BABA ◽  
HITOSHI MAESHIMA ◽  
TAKAHISA SHIMANO ◽  
MEGUMI INOUE ◽  
...  

2008 ◽  
Vol 93 (1-2) ◽  
pp. 176-179 ◽  
Author(s):  
Mathilde M. Husky ◽  
Carolyn M. Mazure ◽  
Prashni Paliwal ◽  
Sherry A. McKee

2003 ◽  
Vol 36 (4) ◽  
pp. 204-212 ◽  
Author(s):  
Malene Grubbe Hildebrandt ◽  
Kurt Bjerregaard Stage ◽  
Per Kragh-Soerensen

2009 ◽  
Vol 24 (S1) ◽  
pp. 1-1
Author(s):  
K. Uebelhack ◽  
L. Franke ◽  
N. Herold ◽  
M. Plotkin ◽  
H. Amthauer ◽  
...  

Aims:The aim was to determine the relation between characteristics of [123I]-ADAM binding to serotonin transporters (SERT) in several brain regions to different symptoms in patients diagnosed with major depressive disorder (MDD) and to analyze data for males and females separately. Differences of [123I]-ADAM binding in patients before and after treatment with Selective Serotonin Reuptake Inhibitor (SSRI) antidepressant Citalopram were assessed.Method:12 non medicated patients (5 females and 7 males) diagnosed with MDD were examined by SPECT with specific Serotonin transporter radioligand [123I]-ADAM before and after treatment with SSRI Citalopram. We administered the dose of 10 mg Citalopram per day intravenously at first day, followed by a 6 days period of oral application. After 7 days of treatment patients were examined for second time with SPECT. The relationships between [123I]-ADAM binding and different aspects of major depression represented by HAMD items, assessed twice by Hamilton Depression-Scale (HAMD) once at baseline and second after treatment period, were evaluated.Results:We found significant correlations with significant gender differences between singular sub items of HAMD and indices of [123I]-ADAM binding in midbrain before and after treatment. These findings points to the need of data analysis separately in males and females. No correlations between HAMD total scores at baseline and indices were found.Conclusion:SERT availability for 123-ADAM binding in the midbrain in drug naives as well as in treated patients with major depression disorder seems to be related to intensity of sub items in the HAMD and the outcome of treatment.


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