Intrasession Reproducibility of RNFL Thickness Measurements Using SD-OCT in Eyes With Keratoconus

AimsTo evaluate the accuracy of the ISNT rule (I=inferior, S=superior, N=nasal, T=temporal) and its variants with neuroretinal rim width and retinal nerve fibre layer (RNFL) thickness measurements differentiating normal from glaucomatous eyes.MethodsThe diagnosis accuracy of the ISNT rule and its variants was evaluated in a population-based study. Neuroretinal rim widths were measured on monoscopic optic disc photographs with an image-processing program. RNFL thickness measurements were obtained with spectral-domain optical coherence tomography (SD-OCT).ResultsIn this study including 940 normal subjects and 93 patients with glaucoma, the sensitivity of the ISNT rule with optic disc photographs was 94.1% (95% CI 90.2 to 98.1), whereas its specificity was 49.2% (46.9 to 51.6). When using the IST rule, the sensitivity decreased to 69.9% (62.1 to 77.6) with a higher specificity, 87.0% (85.3 to 88.6). All the diagnosis indicators were somewhat lower for the different rules using RNFL thickness: the sensitivity of the ISNT rule was 79.4% (72.6 to 86.2) and its specificity was 34.1% (31.9 to 36.4). With the IST rule, the sensitivity decreased to 50.0% (41.6 to 58.4) while the specificity increased to 64.9% (62.7 to 67.2).ConclusionsThe ISNT and IST rules applied to neuroretinal rim width measurement by optic disc photographs are useful and simple tools for differentiating normal from glaucomatous eyes. The translation of these rules to RNFL thickness by SD-OCT is of limited value.

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New Circumpapillary Retinal Nerve Fiber Layer Thickness and Bruch’s Membrane Opening-Minimum Rim Width Assessment in Nonglaucomatous Eyes with Large Discs

Journal of Ophthalmology ◽

10.1155/2019/3431217 ◽

2019 ◽

Vol 2019 ◽

pp. 1-10

Author(s):

Serife Bayraktar ◽

Gulnar Sultanova ◽

Zafer Cebeci ◽

Emre Altinkurt ◽

Belgin Izgi

Keyword(s):

Optic Nerve ◽

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Rnfl Thickness ◽

The Mean ◽

Group 2 ◽

Thickness Measurements ◽

Sd Oct ◽

Group 1

Purpose. To compare the new spectral-domain optical coherence tomography (SD-OCT) algorithm for measuring circumpapillary retinal nerve fiber layer (RNFL) thickness centered on Bruch’s membrane opening (BMO), RNFLBMO1, with the conventional circumpapillary RNFL thickness measurement centered on the optic disc (RNFLDİ), and assess the BMO-minimum rim width (BMO-MRW) in nonglaucomatous eyes with large discs. Methods. This prospective, cross-sectional, observational study included a total of 91 eyes of 91 patients having nonglaucomatous eyes with large discs (Group 1) and 50 eyes of 50 healthy subjects (Group 2). The optic nerve head (ONH) parameters obtained by confocal scanning laser ophthalmoscopy (CSLO), peripapillary RNFL thickness, BMO area, and BMO-MRW were imaged with SD-OCT. Results. The mean disc size was 3.06 ± 0.42 mm2 (range, 2.61–4.68) in Group 1 and 1.95 ± 0.23 mm2 (range, 1.6–2.43) in Group 2 (p=0.0001). The mean BMO area was 2.9 ± 0.58 mm2 (range, 1.26–4.62) in Group 1 and 2.05 ± 0.31 mm2 (range, 1.51–2.82) in Group 2 (p=0.0001). The difference between RNFLDİ and RNFLBMO1 measurements in Group 1 was stronger than in Group 2 because it was significant in all sectors in large discs. The mean global BMO-MRW thickness was significantly thinner in large discs; it was 252.95 ± 42.16 µ (range, 170–420) in Group 1 and 326.06 ± 73.39 µ (range, 210–440) in Group 2 (p=0.0001). There was a positive correlation between BMO-MRW thickness measurements and RNFL thickness parameters, both with RNFLDİ and RNFLBMO1, in global and all optic nerve sectors except temporal quadrants with r = 0.257–0.431 (p≤0.001–0.01) in Group 1. But in control group, Group 2, there was a weak correlation or no correlation between BMO-MRW thickness measurements and RNFL thickness parameters with r = −0.256–0.328 (p=0.797–0.02). Conclusion. The new circumpapillary RNFL scanning algorithm centered on BMO is better to assess the RNFL thickness and BMO-MRW in large discs for the early diagnosis of glaucoma.

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Peripapillary Retinoschisis in Glaucoma Patients

Journal of Ophthalmology ◽

10.1155/2016/1612720 ◽

2016 ◽

Vol 2016 ◽

pp. 1-8 ◽

Cited By ~ 12

Author(s):

Serife Bayraktar ◽

Zafer Cebeci ◽

Melis Kabaalioglu ◽

Serife Ciloglu ◽

Nur Kir ◽

...

Keyword(s):

Clinical Characteristics ◽

Fiber Layer ◽

Rnfl Thickness ◽

Temporal Quadrant ◽

Group 2 ◽

B Scan Images ◽

Thickness Measurements ◽

Sd Oct ◽

Group 1

Purpose. To investigate peripapillary retinoschisis and its effect on retinal nerve fiber layer (RNFL) thickness measurements by using spectral-domain optical coherence tomography (SD-OCT) in glaucomatous eyes.Methods. Circumpapillary RNFL (cpRNFL) B-scan images of 940 glaucoma patients (Group 1) and 801 glaucoma-suspect patients (Group 2) obtained by SD-OCT were reviewed. The structural and clinical characteristics of the retinoschisis were investigated. The RNFL thickness measurements taken at the time of retinoschisis diagnosis and at the follow-up visits were also compared.Results. Twenty-nine retinoschisis areas were found in 26 of the 940 glaucoma patients (3.1%) in Group 1 and seven areas were found in 801 patients (0.87%) in Group 2. In glaucomatous eyes, the retinoschisis was attached to the optic disc and overlapped with the RNFL defect. At the time of retinoschisis, the RNFL thickness was statistically greater in the inferior temporal quadrant when compared with the follow-up scans (p<0.001). No macular involvement or retinal detachment was observed.Conclusion. The present study investigated 33 peripapillary retinoschisis patients. Increase in RNFL thickness measurements was observed at the time of retinoschisis. It is important to examine the cpRNFL B-scan images of glaucoma patients so that the RNFL thickness is not overestimated.

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Retinal thickness among normal myopic Filipinos using spectral domain optical coherence tomography

Asian Journal of Ophthalmology ◽

10.35119/asjoo.v17i2.537 ◽

2020 ◽

Vol 17 (2) ◽

pp. 156-169

Author(s):

Camille Elaine Zabala ◽

Jubaida Mangondato-Aquino ◽

Jose Ma. Martinez ◽

John Mark De Leon

Keyword(s):

Optical Coherence Tomography ◽

High Myopia ◽

Retinal Thickness ◽

Spectral Domain ◽

Pathologic Myopia ◽

Optical Coherence ◽

Fiber Layer ◽

Rnfl Thickness ◽

Thickness Measurements ◽

Sd Oct

Purpose: To determine mean macular and retinal nerve fiber layer (RNFL) thickness of myopic Filipinos using spectral domain optical coherence tomography (SD-OCT) and to evaluate influence of age, gender, and degree of myopia. Design: Observational clinic-based cohort. Methods: Participants were divided into two groups: low-moderate myopia [spherical equivalent (SE) -0.50 D to -6.00 D] and high-pathologic myopia (SE < -6.00 D and AL > 26.5 mm). Subgroup analyses between low myopia (refraction < -3.00 D or less) and moderate myopia (> -3.00 D to -6.00 D), and high myopia (> -6.00 D to -8.00 D) and pathologic myopia (more than -8.00 D) were done. Macular and RNFL thickness were measured by a SD-OCT and axial length (AL) with non-contact biometry. Results: Of 156 eyes, 88/156 (56%) had low-moderate myopia, 68/156 (44%) had high-pathologic myopia. There were 67/156 (43%) male and 89/156 (57%) female subjects. Mean central foveal subfield thickness measurements were 264 ± 24 μm for low myopia, 258 ± 17 μm for moderate myopia, 253 ± 25 μm for high myopia, and 218 ± 48 μm for pathologic myopia. Mean RNFL thickness measurements were 105.62 ± 3.89 μmfor low myopia, 97.6 ± 2.45 μm for moderate myopia, 85.9 ± 3.87 μm for high myopia, and 75.14 ± 3.89 μm for pathologic myopia. Average SE (p < 0.0001) decreased while AL (p < 0.0001) increased with more myopia. Myopia and age significantly affected macular and RNFL thickness parameters except for the following where only the degree of myopia was a significant factor: central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses. Conclusion: Retinal SD-OCT thickness measurements decreased with increasing level of myopia and age. Central foveal, temporal parafoveal, nasal perifoveal, inferior and nasal RNFL thicknesses may be more appropriate SD-OCT parameters among myopic Filipino patients to monitor for glaucoma since they may be less influenced by age.

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Peripapillary Retinal Nerve Fiber Layer (rnfl) Thickness Measurements By Topcon Sd-oct In Myopic Patients

Journal of College of Physicians And Surgeons Pakistan ◽

10.29271/jcpsp.2018.01.26 ◽

2018 ◽

Vol 28 (1) ◽

pp. 26-30 ◽

Cited By ~ 1

Author(s):

Nadia Akhtar ◽

Ayisha Kausar ◽

Farooq Afzal ◽

Syed Khalid Ali ◽

Nida Hamid

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Thickness Measurements ◽

Sd Oct ◽

Retinal Nerve Fiber

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Repeatability of Bruch’s Membrane Opening-minimum Rim Width in Age-related Macular Degeneration and Diabetic Macular Edema

Journal of the Korean Ophthalmological Society ◽

10.3341/jkos.2021.62.11.1490 ◽

2021 ◽

Vol 62 (11) ◽

pp. 1490-1501

Author(s):

Bum Jun Kim ◽

Woo Hyuk Lee ◽

Ki Yup Nam ◽

Ji Hye Kim ◽

Tae Seen Kang ◽

...

Keyword(s):

Macular Degeneration ◽

Macular Edema ◽

Optic Disc ◽

Diabetic Macular Edema ◽

Age Related Macular Degeneration ◽

Disc Membrane ◽

Rnfl Thickness ◽

Age Related ◽

Bruch’S Membrane Opening ◽

Sd Oct

Purpose: To evaluate the repeatability of retinal nerve fiber layer (RNFL) thickness and Bruch’s membrane opening-minimum rim width (BMO-MRW) measurements by spectral-domain optical coherence tomography (SD-OCT) in wet age-related macular degeneration (wAMD) and diabetic macular edema (DME).Methods: This was a prospective study. The RNFL thickness and BMO-MRW parameters for each sector and global average were measured twice by SD-OCT. Repeatability was evaluated using the intraclass correlation coefficient (ICC) and coefficient of variation (CV). If the optic disc membrane was confirmed, it was analyzed by dividing it into three groups based on severity.Results: A total of 99 eyes (48 with wAMD, 51 with DME) were included in the analysis. The ICCs of the global RNFL thickness and global BMO-MRW measurements were 0.996 and 0.997, respectively, in wAMD and 0.994 and 0.996, respectively, in DME eyes. The CV values of global RNFL thickness and BMO-MRW were 0.60% and 0.73%, respectively, in wAMD eyes and 1.10% and 1.21%, respectively, in DME eyes. The disc membrane on the optic nerve head significantly affected global BMO-MRW repeatability (B = 0.814, p < 0.001).Conclusions: Both RNFL thickness and BMO-MRW measurements showed good repeatability in eyes with wAMD and DME. The severity of the optic disc membrane significantly affected the repeatability of BMO-MRW measurements in eyes with wAMD and DME. Therefore, physicians should examine the BMO-MRW in eyes with severe optic disc membrane.

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Macular thickness measurements of healthy, naïve cynomolgus monkeys assessed with spectral-domain optical coherence tomography (SD-OCT)

PLoS ONE ◽

10.1371/journal.pone.0222850 ◽

2019 ◽

Vol 14 (10) ◽

pp. e0222850 ◽

Cited By ~ 2

Author(s):

Nora Denk ◽

Peter Maloca ◽

Guido Steiner ◽

Christian Freichel ◽

Simon Bassett ◽

...

Keyword(s):

Optical Coherence Tomography ◽

Macular Thickness ◽

Spectral Domain ◽

Optical Coherence ◽

Cynomolgus Monkeys ◽

Thickness Measurements ◽

Sd Oct

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Comparison of a commercial spectral-domain OCT and swept-source OCT based on an angiography scan for measuring circumpapillary retinal nerve fibre layer thickness

British Journal of Ophthalmology ◽

10.1136/bjophthalmol-2019-314706 ◽

2019 ◽

Vol 104 (7) ◽

pp. 974-979 ◽

Cited By ~ 2

Author(s):

Bingyao Tan ◽

Jacqueline Chua ◽

Thiyagrajan Harish ◽

Amanda Lau ◽

Alfred Tau Liang Gan ◽

...

Keyword(s):

Nerve Fibre ◽

Excellent Agreement ◽

Retinal Nerve Fibre Layer ◽

Spectral Domain ◽

Wide Field ◽

Swept Source ◽

Rnfl Thickness ◽

Fibre Layer ◽

Nerve Fibre Layer ◽

Sd Oct

Background/aimsTo assess the agreement in measuring retinal nerve fibre layer (RNFL) thickness between spectral-domain (SD; Cirrus HD, Carl Zeiss Meditec, USA) optical coherence tomography (OCT) and swept-source (SS; Plex Elite 9000, Carl Zeiss Meditec) OCT using an OCT angiography (OCTA) scanning protocol.Methods57 participants (12 glaucomatous, 8 ocular hypertensive and 74 normal eyes) were scanned with two OCT instruments by a single experienced operator on the same day. Circumpapillary RNFL thicknesses were automatically segmented for SD-OCT and manually segmented for SS-OCTA scans. Agreement of global RNFL thickness, as well as average thickness in four quadrants was assessed using intraclass correlation coefficients (ICCs).ResultsThere was excellent agreement in the inferior and superior quadrants and the global (all ICC >0.90), followed by good agreement in the temporal (ICC=0.79) and nasal (ICC=0.73) quadrants. The ICC values were similar in the subgroups except within the ocular hypertension group, where the nasal quadrant was less agreeable (ICC=0.31). SS-OCTA-derived RNFL thickness was on average 3 µm thicker than SD-OCT, particularly in the nasal (69.7±11.5 µm vs 66.3±9.3 µm; p<0.001) and temporal (75.6±13.7 µm vs 67.9±12.3 µm; p<0.001) quadrants.ConclusionsRNFL measurements taken with SS-OCTA have good-to-excellent agreement with SD-OCT, which suggests that the RNFL thickness can be sufficiently extracted from wide-field OCTA scans.

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Age-Related Physiologic Thinning Rate of the Retinal Nerve Fiber Layer in Different Levels of Myopia

Journal of Ophthalmology ◽

10.1155/2020/1873581 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Daun Jeong ◽

Kyung Rim Sung ◽

Youn Hye Jo ◽

Sung-cheol Yun

Keyword(s):

Nerve Fiber ◽

Retinal Nerve Fiber Layer ◽

Refractive Error ◽

Fiber Layer ◽

Nerve Fiber Layer ◽

Rnfl Thickness ◽

Significant Difference ◽

Thinning Rate ◽

Sd Oct ◽

Retinal Nerve Fiber

Purpose. To investigate the effect of refractive error on the physiologic thinning rate of the retinal nerve fiber layer (RNFL) in healthy eyes. Materials and Methods. This study analyzed 223 eyes of 141 healthy subjects followed for more than 5 years and underwent at least five serial spectral domain optical coherence tomography (SD-OCT) examinations. Longitudinal RNFL measurements were analyzed by linear mixed models incorporating follow-up duration, baseline RNFL thickness, spherical equivalent (SE), age, intraocular pressure, and visual field mean deviation. Thinning rates were classified according to SE into three groups: nonmyopic (NM; >0 D), mild-to-moderately myopic (MM; >–6 D and ≤0 D), and highly myopic (HM; ≤–6 D). Results. The overall slopes of change in RNFL thickness over time in the NM, MM, and HM groups were −0.305 ± 0.128, −0.294 ± 0.068, and −0.208 ± 0.097 μm/yr, respectively. Slopes of RNFL thickness changes in these groups were −0.514 ± 0.248, −0.520 ± 0.133, and −0.528 ± 0.188 μm/yr, in the superior quadrant; −0.084 ± 0.145, 0.107 ± 0.082, and −0.161 ± 0.112 μm/yr, in the temporal quadrant; −0.807 ± 0.242, −0.794 ± 0.130, and −0.727 ± 0.183 μm/yr, in the inferior quadrant; and 0.160 ± 0.157, 0.118 ± 0.084, and 0.429 ± 0.119 μm/yr, in the nasal quadrant. Overall and in all four quadrants, there was no significant difference in the rate of RNFL thickness change among the three groups. Conclusions. Refractive error did not affect the physiologic thinning rate of RNFL when assessed by SD OCT.

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