scholarly journals Squamous Cell Carcinoma with Clinical Perineural Invasion: Challenges and Review in Single Case Study

2021 ◽  
Vol 15 (11) ◽  
pp. 10-16
Author(s):  
Victor R Chalfant ◽  
David Semerad ◽  
John Gossen ◽  
Antonia Gurney ◽  
Cam Nguyen
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Perineural Invasion ◽  
Early Recognition ◽  
Single Case ◽  
External Beam Radiotherapy ◽  
Mri Findings ◽  
Radiation Induced ◽  
The Right

Perineural invasion is a rare prognostic finding of squamous cell carcinomas that is associated with a poor prognosis. Early recognition of perineural invasion is imperative to improving treatment and lowering recurrence. Here we report the case of a 77-year-old Caucasian male with a suspicious mass on his forehead. Diagnosis confirms a squamous cell carcinoma with T1-weighted MRI findings significant for perineural invasion of the right supratrochlear nerve based on nerve thickening with loss of fat. Due to his immunocompromised status and the presence of positive margins after wide local excision, the patient is treated with adjuvant external beam radiotherapy of the nerve course. Risks of radiation-induced optic neuropathy should be weighed against recurrence in tumors that invade the trigeminal nerve.

scholarly journals Perineural Invasion of Squamous Cell Carcinoma of the Lip with Occult Involvement of the Infra-orbital Nerve Detected by PET-CT and Treated with MRI-based IMRT: A Case Report

2005 ◽  
Vol 4 (3) ◽  
pp. 251-253 ◽  
Author(s):  
Ajay K. Bhatnagar ◽  
Dwight E. Heron ◽  
Barry Schaitkin
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Perineural Invasion ◽  
Infraorbital Nerve ◽  
Upper Lip ◽  
Pet Ct ◽  
Facial Numbness ◽  
The Right

A 51 year old male with a history of right facial numbness developed progressive upper lip swelling for one year, but an MRI of the head was unremarkable. A wide local excision of the upper lip was performed and pathology revealed a 1.7 cm mass, poorly differentiated squamous cell carcinoma with perineural invasion. Surgical margins were free of tumor. Two months postoperatively, a hybrid PET-CT of the whole body was performed due to the persistent right facial numbness. The CT portion identified an equivocal lesion at the base of the right orbit correlating to the right infraorbital nerve. However, the PET-CT image revealed avid uptake in this location suggesting perineural invasion which was confirmed with biopsy of the right infraorbital nerve demonstrating carcinoma. Subsequently, the patient was treated with Intensity Modulation Radiation Therapy (IMRT) using MRI fusion for proper delineation of the right infraorbital nerve to its origin in the base of skull. This case exemplifies the superiority of hybrid PET-CT over CT or MRI alone in head and neck imaging which can lead to significant impact on management for patients with head and neck cancer.

The Length of Peri-Neural Spreading in Clinically Mandibular Invaded Oral Cavity Squamous Cell Carcinoma

2020 ◽  
pp. 459-464
Keyword(s):  
Squamous Cell Carcinoma ◽  
Oral Cavity ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lymphovascular Invasion ◽  
Perineural Invasion ◽  
Inferior Alveolar Nerve ◽  
Surgical Margin ◽  
Neural Invasion ◽  
Resected Margin

Background: The objective of surgical management of oral squamous cell carcinoma (OSCC) is adequate resection with a clear margin. However, there is still a debate as to the optimal length for a mandibular resected margin. Objective: To examine the length of peri-neural spreading in T4 mandibular invaded oral cavity squamous cell carcinoma. Materials and Methods: Twenty-eight T4 pathological OSCC specimens that involved mandible and serial slices were studied and the length of tumor spreading along the inferior alveolar nerve (IAN) was determined. Tumor characteristics, risk factors, and survival were analyzed. Results: The incidence of peri-neural invasion was 11.11%, and IAN invasion was found in 14.29% of the tumor-invaded mandibular marrow. The length of tumor spreading along IAN was 3 to 12 mm. Poor prognostic factors of T4 OSCC were it being located on the tongue (HR 14.16), was pathological N2-3 (HR 31.05), and had high-risk features such as peri-neural invasion, lymphovascular invasion, and extra-nodal extension. Conclusion: A mandibular resected margin of at least 18 mm is recommended as a clear surgical margin in cases of T4 mandibular invasion OSCC. Keywords: Oral cancer, Perineural invasion, Inferior alveolar nerve, Squamous cell carcinoma, Mandibulectomy

scholarly journals Squamous Cell Carcinoma Arising at a Skin Graft Donor Site: Case Report and Review of the Literature

2021 ◽  
Vol 7 ◽  
pp. 2513826X2110084
Author(s):  
Weston Thomas ◽  
Kevin Rezzadeh ◽  
Kristie Rossi ◽  
Ajul Shah
Keyword(s):  
Squamous Cell Carcinoma ◽  
Case Report ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Skin Graft ◽  
Donor Site ◽  
Skin Grafting ◽  
Excisional Biopsy ◽  
Graft Donor ◽  
The Right

Introduction: Skin graft reconstruction is a common method of providing wound coverage. Rarely, skin grafting can be associated with the development of squamous cell carcinoma (SCC) in the graft donor site. Case Report: The patient is a 72-year old male with a 15-year history of bilateral hip wounds. He underwent a multitude of treatments previously with failed reconstructive efforts. After presenting to us, he underwent multiple debridements and eventual skin grafting. Within 4 weeks of the final skin graft, a mass developed at the skin graft donor site at the right thigh. Excisional biopsy returned a well differentiated keratinizing SCC. Discussion/Conclusion: This case demonstrates the acute presentation of SCC in a patient following a skin graft without known risk factors. The purpose of this unique case report is to highlight a very rare occurrence of SCC at a skin graft donor site.

scholarly journals Squamous Cell Carcinoma of Kidney and Its Prognosis: A Case Report and Review of the Literature

2015 ◽  
Vol 2015 ◽  
pp. 1-3 ◽  
Author(s):  
Tapan Kumar Sahoo ◽  
Saroj Kumar Das ◽  
Chandraprava Mishra ◽  
Ipsita Dhal ◽  
Rohani Nayak ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Radical Nephrectomy ◽  
Advanced Stage ◽  
Rare Entity ◽  
Primary Squamous Cell Carcinoma ◽  
Review Of The Literature ◽  
Radiological Features ◽  
The Right

Primary squamous cell carcinoma of the renal parenchyma is an extremely rare entity. The diagnosis of squamous cell carcinoma of the renal pelvis is usually unsuspected due to the rarity and inconclusive clinical and radiological features. Most of the patients are diagnosed at an advanced stage and are with poor outcome. Radical nephrectomy is the mainstay of the treatment. We reported a case of squamous cell carcinoma of the kidney in a 50-year-old female who presented with the right sided abdomen pain. The patient was treated with radical nephrectomy.

Immediate Functional Loading of an Implant-Supported Fixed Prosthesis at the Time of Ablative Surgery and Mandibular Reconstruction for Squamous Cell Carcinoma

2010 ◽  
Vol 36 (3) ◽  
pp. 225-230 ◽  
Author(s):  
Guillaume Odin ◽  
Thierry Balaguer ◽  
Charles Savoldelli ◽  
Gérard Scortecci
Keyword(s):  
Squamous Cell Carcinoma ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
External Beam Radiotherapy ◽  
Mandibular Reconstruction ◽  
Implant Placement ◽  
Fibula Free Flap ◽  
Ablative Surgery ◽  
Fixed Prosthesis ◽  
Implant Loading

Abstract The authors describe a case of squamous cell carcinoma of the oral cavity managed by ablative surgery, mandibular reconstruction with a fibula free flap, and implant placement during the same session. Immediate functional implant loading, respecting the principles of basal implantology, was performed 48 hours later using a highly rigid, screw-secured fixed prosthesis that served as an external fixator for the implants and grafted bone. Implant loading before external beam radiotherapy improves flap stability, bone consolidation, and quality of life. Functional and esthetic outcomes were evaluated 2 years after radiotherapy was completed.

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