scholarly journals Soy isoflavone phase II metabolism differs between rodents and humans: implications for the effect on breast cancer risk

2011 ◽  
Vol 94 (5) ◽  
pp. 1284-1294 ◽  
Author(s):  
Kenneth DR Setchell ◽  
Nadine M Brown ◽  
Xueheng Zhao ◽  
Stephanie L Lindley ◽  
James E Heubi ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Phase Ii ◽  
Phase Ii Metabolism ◽  
Soy Isoflavone

scholarly journals Soy Isoflavone Supplementation for Breast Cancer Risk Reduction: A Randomized Phase II Trial

2012 ◽  
Vol 5 (2) ◽  
pp. 309-319 ◽  
Author(s):  
Seema A. Khan ◽  
Robert T. Chatterton ◽  
Nancy Michel ◽  
Michelle Bryk ◽  
Oukseub Lee ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Risk Reduction ◽  
Phase Ii ◽  
Phase Ii Trial ◽  
Soy Isoflavone ◽  
Randomized Phase Ii ◽  
Breast Cancer Risk Reduction ◽  
Cancer Risk Reduction

scholarly journals Phase II study of metformin for reduction of obesity-associated breast cancer risk: a randomized controlled trial protocol

BMC Cancer ◽  
2016 ◽  
Vol 16 (1) ◽  
Author(s):  
Jessica A. Martinez ◽  
Pavani Chalasani ◽  
Cynthia A. Thomson ◽  
Denise Roe ◽  
Maria Altbach ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Randomized Controlled Trial ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Phase Ii ◽  
Phase Ii Study ◽  
Controlled Trial ◽  
Trial Protocol ◽  
Randomized Controlled

Abstract 912: Soy isoflavone intake,MDM2gene polymorphism and breast cancer risk among Chinese women in Singapore

2010 ◽  
Author(s):  
Woon-Puay Koh ◽  
Renwei Wang ◽  
David Van Den Berg ◽  
Jian-Min Yuan ◽  
Mimi C. Yu
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Chinese Women ◽  
Soy Isoflavone

New advances in the understanding of the role of steroids and steroid receptors in disease

2001 ◽  
Vol 29 (2) ◽  
pp. 205-209 ◽  
Author(s):  
H. Wiseman ◽  
R. Duffy
Keyword(s):  
Breast Cancer ◽  
Breast Cancer Risk ◽  
Cancer Risk ◽  
Oestrogen Receptor ◽  
Steroid Receptors ◽  
Disease Development ◽  
Soy Isoflavone ◽  
Dietary Consumption ◽  
Related Compounds

Steroids and related compounds are important in disease development and prevention, via steroid receptor-mediated and receptor-independent mechanisms. Interaction of endogenous oestrogens with the oestrogen receptor has unfortunate mitogenic effects in breast cancer. However, dietary consumption of non-steroidal weak oestrogens, such as the soy isoflavone phytoestrogens genistein and diadzein, is associated with a decreased breast cancer risk. This may arise in part from the suboptimal configuration induced in the transactivation helix of oestrogen receptor-β.

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