scholarly journals Dietary Flavonoid Intake Reduces the Risk of Head and Neck but Not Esophageal or Gastric Cancer in US Men and Women

2017 ◽  
Keyword(s):  
Gastric Cancer ◽  
Head And Neck ◽  
Men And Women ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

Author Response: Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women

Neurology ◽  
2021 ◽  
Vol 97 (23) ◽  
pp. 1095-1095
Author(s):  
Tian-Shin Yeh ◽  
Changzheng Yuan ◽  
Alberto Ascherio ◽  
Bernard A. Rosner ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Author Response ◽  
Subjective Cognitive Decline ◽  
Men And Women ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

scholarly journals A Prospective Study of Dietary Flavonoid Intake and Risk of Glioma in US Men and Women

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 263-263
Author(s):  
Alaina Bever ◽  
Aedin Cassidy ◽  
Eric Rimm ◽  
Meir Stampfer ◽  
David Cote
Keyword(s):  
Total Flavonoid ◽  
Health Study ◽  
Men And Women ◽  
Funding Sources ◽  
Flavonoid Intake ◽  
Glioma Risk ◽  
Dietary Flavonoid ◽  
Incident Cases

Abstract Objectives Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease glioma risk, an association that has not yet been investigated in humans. The objective of this study was to evaluate the association between dietary flavonoid consumption and glioma risk in participants in the female Nurses’ Health Study (1984–2014, n = 81,688) and Nurses’ Health Study II (1991–2017, n = 95,228), and the male Health Professionals Follow-up Study (1986–2014, n = 49,884). Methods Exposure was average long-term (up to 30 years) and recent (up to 12 years) intake of total flavonoids and six flavonoid subclasses, derived from validated quadrennial food frequency questionnaires. The primary outcome was incident glioma, confirmed by medical record review. Results We documented 536 incident cases of glioma across 5,936,386 person-years of follow-up. Long-term total flavonoid, flavan-3-ol, and polymer intake was associated with decreased glioma risk in pooled analyses comparing highest to lowest quintile of consumption (total flavonoid hazard ratio (HR) = 0.79, 95% CI: 0.59–1.05, P-trend = 0.04; flavan-3-ol HR = 0.76, 95% CI: 0.57–1.01, P-trend = 0.04; polymer HR = 0.82, 95% CI: 0.61–1.09, P-trend = 0.05). Associations with recent intake were weaker and not statistically significant. There were no associations with other flavonoid subclasses. After additional adjustment for tea consumption, there was no significant association between flavan-3-ol or polymer consumption and glioma. Conclusions Increased dietary intake of flavan-3-ol and polymeric flavonoids, especially those predominant in tea, was associated with decreased glioma risk in a prospective cohort of men and women. Habitual consumption of foods and beverages containing flavan-3-ols and polymeric flavonoids may protect against the development of glioma. Funding Sources This work was supported by the U.S. National Institutes of Health.

scholarly journals Dietary flavonoid intake and weight maintenance: three prospective cohorts of 124 086 US men and women followed for up to 24 years

BMJ ◽  
2016 ◽  
pp. i17 ◽  
Author(s):  
Monica L Bertoia ◽  
Eric B Rimm ◽  
Kenneth J Mukamal ◽  
Frank B Hu ◽  
Walter C Willett ◽  
...  
Keyword(s):  
Weight Maintenance ◽  
Men And Women ◽  
Flavonoid Intake ◽  
Prospective Cohorts ◽  
Dietary Flavonoid

Relationships Between Dietary Flavonoid Intake, Gut Microbiota, And Asthma Clinical Features

2021 ◽  
Vol 147 (2) ◽  
pp. AB49
Author(s):  
Michelle El-Hosni ◽  
Ariangela Kozik ◽  
Molly Cook ◽  
Research Lab Tech ◽  
Alan Baptist ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Clinical Features ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

scholarly journals Dietary flavonoid intake and risk of incident depression in midlife and older women

2016 ◽  
Vol 104 (3) ◽  
pp. 704-714 ◽  
Author(s):  
Shun-Chiao Chang ◽  
Aedin Cassidy ◽  
Walter C Willett ◽  
Eric B Rimm ◽  
Eilis J O’Reilly ◽  
...  
Keyword(s):  
Older Women ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

scholarly journals Establishment and validation of pre-therapy cervical vertebrae muscle quantification as a prognostic marker of sarcopenia in head and neck patients receiving definitive cancer surgery

2021 ◽  
Author(s):  
Brennan Olson ◽  
Jared Edwards ◽  
Catherine Degnin ◽  
Nicole Santucci ◽  
Michelle Buncke ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Overall Survival ◽  
Head And Neck ◽  
Cervical Vertebrae ◽  
Ct Imaging ◽  
Primary Study ◽  
Muscle Area ◽  
Cross Sectional ◽  
Men And Women ◽  
Muscle Cross Sectional Area

Importance: Sarcopenia, or diminished skeletal muscle mass, is prognostic for survival in patients with head and neck cancer (HNC). However, identification of this high-risk feature remains challenging for patients without computed tomography (CT) images that capture the abdomen or lower thorax. Objectives: To (1) define sarcopenia thresholds at the C3 vertebral level using previously established thresholds derived from abdominal CT imaging and (2) determine if C3-defined sarcopenia is associated with survival in patients with HNC. Design, setting, and participants: This retrospective cohort study was conducted in consecutive patients with a squamous cell carcinoma of the head and neck with cross-sectional abdominal or neck imaging within 60 days prior to treatment and treated between January 2005 and December 2017. Data analysis was completed from December 2018 to April 2021. Exposures: Measurement of the cross-sectional muscle area at the third lumbar and cervical vertebral levels using CT imaging. Main outcomes and measures: Primary study outcome was overall survival. Results: In a cohort of 253 HNC patients with CT imaging that captures both L3 and C3 vertebral levels, skeletal muscle cross-sectional area at C3 was strongly correlated with the L3 level in both men (n = 188; r = 0.77; p < 0.001) and women (n = 65; r = 0.80; p < 0.001), and C3-defined sarcopenia thresholds of 14.0 cm2/m2 (men) and 11.1 cm2/m2 (women) were best predictive of previously established L3-defined sarcopenia thresholds. Applying these defined C3 sarcopenia thresholds in a cohort of 536 HNC patients with neck imaging alone revealed that C3-defined sarcopenia was independently associated with reduced overall survival in men (HR = 2.63; 95% CI, 1.79, 3.85) but not women (HR = 1.18, 95% CI, 0.76, 1.85) with HNC. Conclusions and relevance: This study identifies sarcopenia thresholds at the C3 level that best predict L3-defined sarcopenia in both men and women. In HNC, C3-defined sarcopenia is associated with poor survival outcomes in men, but not women, suggesting sarcopenia may differentially affect men and women with HNC.

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