scholarly journals A Prospective Study of Dietary Flavonoid Intake and Risk of Glioma in US Men and Women

2021 ◽  
Vol 5 (Supplement_2) ◽  
pp. 263-263
Author(s):  
Alaina Bever ◽  
Aedin Cassidy ◽  
Eric Rimm ◽  
Meir Stampfer ◽  
David Cote
Keyword(s):  
Total Flavonoid ◽  
Health Study ◽  
Men And Women ◽  
Funding Sources ◽  
Flavonoid Intake ◽  
Glioma Risk ◽  
Dietary Flavonoid ◽  
Incident Cases

Abstract Objectives Flavonoids are a diverse group of plant constituents with demonstrated neuroprotective and anti-tumor effects. Flavonoid intake may decrease glioma risk, an association that has not yet been investigated in humans. The objective of this study was to evaluate the association between dietary flavonoid consumption and glioma risk in participants in the female Nurses’ Health Study (1984–2014, n = 81,688) and Nurses’ Health Study II (1991–2017, n = 95,228), and the male Health Professionals Follow-up Study (1986–2014, n = 49,884). Methods Exposure was average long-term (up to 30 years) and recent (up to 12 years) intake of total flavonoids and six flavonoid subclasses, derived from validated quadrennial food frequency questionnaires. The primary outcome was incident glioma, confirmed by medical record review. Results We documented 536 incident cases of glioma across 5,936,386 person-years of follow-up. Long-term total flavonoid, flavan-3-ol, and polymer intake was associated with decreased glioma risk in pooled analyses comparing highest to lowest quintile of consumption (total flavonoid hazard ratio (HR) = 0.79, 95% CI: 0.59–1.05, P-trend = 0.04; flavan-3-ol HR = 0.76, 95% CI: 0.57–1.01, P-trend = 0.04; polymer HR = 0.82, 95% CI: 0.61–1.09, P-trend = 0.05). Associations with recent intake were weaker and not statistically significant. There were no associations with other flavonoid subclasses. After additional adjustment for tea consumption, there was no significant association between flavan-3-ol or polymer consumption and glioma. Conclusions Increased dietary intake of flavan-3-ol and polymeric flavonoids, especially those predominant in tea, was associated with decreased glioma risk in a prospective cohort of men and women. Habitual consumption of foods and beverages containing flavan-3-ols and polymeric flavonoids may protect against the development of glioma. Funding Sources This work was supported by the U.S. National Institutes of Health.

Author Response: Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women

Neurology ◽  
2021 ◽  
Vol 97 (23) ◽  
pp. 1095-1095
Author(s):  
Tian-Shin Yeh ◽  
Changzheng Yuan ◽  
Alberto Ascherio ◽  
Bernard A. Rosner ◽  
Walter C. Willett ◽  
...  
Keyword(s):  
Cognitive Decline ◽  
Author Response ◽  
Subjective Cognitive Decline ◽  
Men And Women ◽  
Flavonoid Intake ◽  
Dietary Flavonoid

Long-term Dietary Flavonoid Intake and Subjective Cognitive Decline in US Men and Women

Neurology ◽  
2021 ◽  
pp. 10.1212/WNL.0000000000012454
Author(s):  
Tian-Shin Yeh ◽  
Changzheng Yuan ◽  
Alberto Ascherio ◽  
Bernard Rosner ◽  
Walter Willett ◽  
...  
Keyword(s):  
Dietary Intake ◽  
Cognitive Decline ◽  
Dietary Factors ◽  
Health Study ◽  
Subjective Cognitive Decline ◽  
Men And Women ◽  
Lower Odds ◽  
Flavonoid Intake ◽  
Dietary Flavonoids

Objective:To prospectively examine the associations between long-term dietary flavonoids and subjective cognitive decline (SCD).Methods:We followed 49,493 women from the Nurses’ Health Study (NHS) (1984-2006) and 27,842 men from the Health Professionals Follow-up Study (HPFS) (1986-2002). Poisson regression was used to evaluate the associations between dietary flavonoids (flavonols, flavones, flavanones, flavan-3-ols, anthocyanins, polymeric flavonoids, and proanthocyanidins) and subsequent SCD. For the NHS, long-term average dietary intake was calculated from seven repeated food frequency questionnaires (SFFQs), and SCD was assessed in 2012 and 2014. For the HPFS, average dietary intake was calculated from five repeated SFFQs, and SCD assessed in 2008 and 2012.Results:Higher intake of total flavonoids was associated with lower odds of SCD after adjusting for age, total energy intake, major non-dietary factors, and specific dietary factors. Comparing the highest versus the lowest quintiles of total flavonoid intake, the pooled multivariable-adjusted odds ratios (ORs) (95% CIs) of 3-unit increments in SCD was 0.81 (0.76, 0.89). In the pooled results, the strongest associations were observed for flavones (OR=0.62 [0.57, 0.68]), flavanones (0.64 [0.58, 0.68)]), and anthocyanins (0.76 [0.72, 0.84]) (p trend <0.0001 for all groups). The dose-response curve was steepest for flavones, followed by anthocyanins. Many flavonoid-rich foods, such as strawberries, oranges, grapefruits, citrus juices, apples/pears, celery, peppers, and bananas, were significantly associated with lower odds of SCD.Conclusion:Our findings support a benefit of higher flavonoid intakes for maintaining cognitive function in US men and women.

scholarly journals Sleep arousal burden is associated with long-term all-cause and cardiovascular mortality in 8001 community-dwelling older men and women

2021 ◽  
Author(s):  
Sobhan Salari Shahrbabaki ◽  
Dominik Linz ◽  
Simon Hartmann ◽  
Susan Redline ◽  
Mathias Baumert
Keyword(s):  
Hazard Analysis ◽  
Osteoporotic Fractures ◽  
Community Dwelling ◽  
Health Study ◽  
Sleep Study ◽  
Men And Women ◽  
Cox Proportional Hazard ◽  
All Cause Mortality

Abstract Aims  To quantify the arousal burden (AB) across large cohort studies and determine its association with long-term cardiovascular (CV) and overall mortality in men and women. Methods and results  We measured the AB on overnight polysomnograms of 2782 men in the Osteoporotic Fractures in Men Study (MrOS) Sleep study, 424 women in the Study of Osteoporotic Fractures (SOF) and 2221 men and 2574 women in the Sleep Heart Health Study (SHHS). During 11.2 ± 2.1 years of follow-up in MrOS, 665 men died, including 236 CV deaths. During 6.4 ± 1.6 years of follow-up in SOF, 105 women died, including 47 CV deaths. During 10.7 ± 3.1 years of follow-up in SHHS, 987 participants died, including 344 CV deaths. In women, multivariable Cox proportional hazard analysis adjusted for common confounders demonstrated that AB is associated with all-cause mortality [SOF: hazard ratio (HR) 1.58 (1.01–2.42), P = 0.038; SHHS-women: HR 1.21 (1.06–1.42), P = 0.012] and CV mortality [SOF: HR 2.17 (1.04–4.50), P = 0.037; SHHS-women: HR 1.60 (1.12–2.28), P = 0.009]. In men, the association between AB and all-cause mortality [MrOS: HR 1.11 (0.94–1.32), P = 0.261; SHHS-men: HR 1.31 (1.06–1.62), P = 0.011] and CV mortality [MrOS: HR 1.35 (1.02–1.79), P = 0.034; SHHS-men: HR 1.24 (0.86–1.79), P = 0.271] was less clear. Conclusions Nocturnal AB is associated with long-term CV and all-cause mortality in women and to a lesser extent in men.

scholarly journals Dietary Nicotine Intake and Risk of Parkinson Disease: A Prospective Study

2020 ◽  
Vol 4 (Supplement_2) ◽  
pp. 1222-1222
Author(s):  
Chaoran Ma ◽  
Samantha Molsberry ◽  
Yanping Li ◽  
Michael Schwarzschild ◽  
Alberto Ascherio ◽  
...  
Keyword(s):  
Lower Risk ◽  
Environmental Tobacco Smoke Exposure ◽  
Tobacco Smoke Exposure ◽  
Health Study ◽  
Inverse Association ◽  
Nicotine Intake ◽  
Funding Sources ◽  
A Prospective Study ◽  
Incident Cases

Abstract Objectives To prospectively examine the association between dietary nicotine intake and subsequent PD risk among never-smokers. Methods The current study was based on never-smoker participants from two large prospective cohorts: the Nurses’ Health Study (n = 31,615) and the Health Professionals’ Follow-up Study (n = 19,523). The studies contained information on dietary nicotine intake from 1986 from validated food frequency questionnaires. Dietary nicotine intake was calculated based on consumption of peppers, tomatoes, processed tomatoes, potatoes, and tea. Incident cases of PD were identified via questionnaires and subsequently confirmed by reviewing medical records. We used Cox proportional hazard models to calculate cohort-specific hazard ratios (HRs), and used fix-effects models to calculate the pooled hazard ratio. Results During 26 years of follow-up, we identified 601 incident PD cases (296 women, and 305 men). After adjusting for potential covariates, the pooled HR for the highest vs. lowest quintile of dietary nicotine intake was 0.70 (95% confidence interval [CI], 0.51–0.94). The significant inverse association was, however, only observed in women (adjusted HR, 0.64; 95% CI, 0.42–0.96), but not in men (adjusted HR, 0.77; 95% CI, 0.50–1.20). Further adjusting for environmental tobacco smoke exposure generated similar significant results in women. Consistently, greater consumption of peppers was associated with lower risk of PD (adjusted HR for ≥5 times/week vs. ≤3 times/month, 0.49; 95% CI, 0.25–0.94) in women but not in men (adjusted HR, 1.04; 95% CI, 0.57–1.90). Conclusions Women with greater consumption of dietary nicotine intake had a lower risk of PD, relative to those with lower consumption. Funding Sources This work was supported by the National Institute of Neurological Disorders and Stroke at the National Institutes of Health (NINDS 1R03NS093245–01A1 to X.G.). The NHS is funded by the National Institute of Health through grant UM1 CA186107. The HPFS cohort is funded by the National Institute of Health through grant UM1 CA 167,552.

Abstract P415: Multivitamin Use and the Risk of Cardiovascular Disease in Men

Circulation ◽  
2014 ◽  
Vol 129 (suppl_1) ◽  
Author(s):  
Susanne Rautiainen ◽  
Robert J Glynn ◽  
Julie E Buring ◽  
J. Michael Gaziano ◽  
Howard D Sesso
Keyword(s):  
Cardiovascular Disease ◽  
Cox Proportional Hazards ◽  
Health Study ◽  
Inverse Association ◽  
Healthy Men ◽  
Wide Range ◽  
Multivitamin Use ◽  
Incident Cases

Background: Although multivitamins are widely used by US adults, few prospective studies have investigated their association with the long- and short-term risk of cardiovascular disease (CVD). The aim of this study was to investigate how multivitamin use is associated with the risk of CVD in initially healthy men free of CVD at baseline. Methods: We studied 21,981 male physicians aged ≥40y from the Physicians Health Study I cohort who were free of CVD and cancer at baseline starting in 1982. All men provided a wide range of self-reported lifestyle and clinical factors plus intake of selected food and dietary supplements. Men were categorized at baseline as (1) no current use and (2) current use of multivitamins. Men were followed from baseline to the end of PHS I follow-up. Cox proportional hazards models were used to calculate multivariable-adjusted rate ratios (RR) (95% confidence intervals (CI)). Results: During an average of 13.7 y (total of 301,480 person-years) of follow-up, there were 1,269 incident cases of major CVD (defined as nonfatal myocardial infarction (MI), nonfatal stroke, and CVD death). In multivariable analyses, there were no statistically significant RRs (95% CIs) observed when comparing current multivitamin use versus no use for the risk of major CVD events (0.97 (0.79-1.04)), MI (0.94 (0.76-1.16), stroke (0.97 (0.77-1.23), or CVD death (1.02 (0.83-1.14)) but an inverse association was observed for cardiac revascularization (0.87 (0.75-1.00)). Conclusion: In this long-term prospective study among initially healthy men, baseline multivitamin use was not associated with the long-term risk of major CVD events.

scholarly journals Height in Adolescence as a Risk Factor for Glioma Subtypes: a Nationwide Retrospective Cohort Study of 2.2 Million Subjects

2021 ◽  
Author(s):  
Roi Tschernichovsky ◽  
Lior H Katz ◽  
Estela Derazne ◽  
Matan Ben-Zion Berliner ◽  
Maya Simchoni ◽  
...  
Keyword(s):  
Risk Factor ◽  
Statistical Significance ◽  
Positive Association ◽  
High Grade Glioma ◽  
Low Grade ◽  
Cox Proportional Hazard ◽  
Cox Proportional Hazard Models ◽  
Glioma Risk ◽  
Incident Cases

Abstract Background Gliomas manifest in a variety of histological phenotypes with varying aggressiveness. The etiology of glioma remains largely unknown. Taller stature in adulthood has been linked with glioma risk. The aim of this study was to discern whether this association can be detected in adolescence. Methods The cohort included 2,223,168 adolescents between the ages of 16-19. Anthropometric measurements were collected at baseline. Incident cases of glioma were extracted from the Israel National Cancer Registry over a follow-up period spanning 47,635,745 person-years. Cox proportional hazard models were used to estimate the hazard ratio for glioma and glioma subtypes according to height, body mass index (BMI) and sex. Results 1,195 patients were diagnosed with glioma during the study period. Mean(SD) age at diagnosis was 38.1 (11.7) years. Taller adolescent height (per 10cm increase) was positively associated with the risk for glioma of any type (HR 1.15; p=0.002). The association was retained in subgroup analyses for low-grade glioma (HR 1.17; p=0.031), high-grade glioma (HR 1.15; p=0.025), oligodendroglioma (HR 1.31; p=0.015), astrocytoma (HR 1.12; p=0.049), and a category of presumed IDH-mutated glioma (HR 1.17; p=0.013). There was a trend towards a positive association between height and glioblastoma, however this had borderline statistical significance (HR: 1.15; p=0.07). After stratification of the cohort by sex, height remained a risk factor for men, but not for women. Conclusions The previously - established association between taller stature in adulthood and glioma risk can be traced back to adolescence. The magnitude of association differs by glioma subtype.

Sign in / Sign up

Export Citation Format

Share Document