MORPHOLOGICAL STUDY OF THE NASAL MUCOUS MEMBRANE IN THE AREAS PRONE TO BLEED Part I Blood vessels in nasal mucous membrane of human fetus Part II Special vascular structure in nasal cavity

Objectives to assess the features of the inflammatory process of the nasal mucous membrane and sinuses in patients with сhronic rhinosinusitis with nasal polyps (CRSwNP). Material and methods. We analyzed the results of examination of 44 patients with CRSwNP. The objects of investigation were smears-reprints from the mucous membrane of the middle turbinate (rhinocytograms) and the intensity of the extracellular peroxidase activity of the lavage fluids of the maxillary sinuses. The data obtained were processed using the Statistica 8.0 software. Results. When analyzing rhinocytograms of the mucous membrane of the middle turbinates, the epithelial type of rhinocytogram was most often detected in 65.9% of cases (epithelial cells more than 50%); the eosinophilic type in 22.7% (eosinophils more than 1%) and smears with mast cells in 4.6% of cases; the neutrophilic type was less frequent (neutrophils more than 50%) 6.8% of cases. In 34.1% of patients, the cells of the columnar epithelium had pronounced changes in the cytoplasm (vacuolization and enzymatic activity); and in 38.6% of cases the gross pathology was recorded directly in the nucleus of the cells (nucleoli, granules, destruction of the nucleus). The revealed pathology of the cell nucleus suggests the viral etiology of the development of productive inflammation in the nasal cavity and sinuses In the lavage fluids of the maxillary sinuses, a high intensity of extracellular peroxidase activity was recorded (1777.9132.4 a.u. compared to 1225.0190.9 a.u. in patients with chronic purulent rhinosinusitis and 1245.0362.3 a.u. in patients with purulent-polypous rhinosinusitis). Conclusion. Chronic rhinosinusitis with nasal polyps is accompanied by a pronounced inflammatory process of the nasal mucous membrane and paranasal sinuses in the form of structural and functional changes in the cells of the columnar epithelium and a high intensity of extracellular peroxidase activity. The epithelial nucleus damage (the presence of nucleoli, granules, destruction of the nucleus) suggests a viral nature with the development of productive inflammation in the nasal cavity and sinuses.

Download Full-text

NASAL MUCOUS MEMBRANE MICROFLORA IN PATIENTS WITH POLYPOUS RHINOSINUSITIS

Russian Journal of Infection and Immunity ◽

10.15789/2220-7619-2016-4-366-372 ◽

2017 ◽

Vol 6 (4) ◽

pp. 366-372

Author(s):

O. A. Kolenchukova ◽

S. V. Smirnova ◽

A. M. Lapteva

Keyword(s):

Mucous Membrane ◽

Nasal Mucous Membrane

Download Full-text

Prevention and conservative treatment of nasopharyngeal tonsil hypertrophy

Russian otorhinolaryngology ◽

10.18692/1810-4800-2021-1-56-60 ◽

2021 ◽

Vol 20 (1) ◽

pp. 56-60

Author(s):

G. I. Markov ◽

◽

A. L. Klochikhin ◽

V. A. Romanov ◽

M. G. Markov ◽

...

Keyword(s):

Conservative Treatment ◽

Nasal Cavity ◽

Mucous Membrane ◽

Conservative Therapy ◽

Pediatric Patients ◽

Surgical Intervention ◽

Whole Body ◽

Fungal Flora ◽

Sparing Effect ◽

Pharyngeal Tonsil

The aim of this work is to draw the attention of otorhinolaryngologists to the advantages of early conservative treatment of children with hypertrophy of the nasopharyngeal tonsil - adenoids. In childhood, a significant part of the protective and informational functions lies on the pharyngeal tonsil, since it is in the path of inhaled air. Unfavourable environmental conditions exacerbate its functional failure. Pathology of the lymphopharyngeal ring is highly prevalent and occupies a leading place among ENT diseases in children. Each person has a certain own microflora on the nasal mucosa from birth. In most cases, monoflora is determined on the mucous membrane of the nasal cavity, and only 2-3% is due to the combination of two types of microbial and fungal flora. For more than twenty years, we have been using the tactics of a sparing effect on the mucous membrane when using medicinal mixtures on a protective basis. Conservative treatment of 245 children aged 3 to 6 years with grade 1 – 2 adenoiditis was carried out, which made it possible to avoid surgical intervention in this group of children. When choosing a drug mixture, the sensitivity of the microflora of the patient’s nasal cavity was considered according to the results of a smear from the mucous membrane. Adenoidectomy is an operation with potentially undesirable consequences for the whole body, therefore, effective timely conservative therapy can reduce the risks and harms of surgery for pediatric patients.

Download Full-text

Morphofunctional State of the Maxillary Sinus Mucosa in Patients After Endoscopic Infundibulotomy

International Journal of Advanced Dental Sciences and Technology ◽

10.35940/ijadst.c1006.101321 ◽

2021 ◽

Vol 1 (3) ◽

pp. 6-10

Author(s):

Djuraev Jamolbek Abdukakharovich ◽

◽

Makhsitaliev Mukhammadbobur Ibrokhimovich, Ibrokhimovich ◽

Keyword(s):

Nasal Cavity ◽

Maxillary Sinus ◽

Chronic Rhinosinusitis ◽

Mucous Membrane ◽

Paranasal Sinuses ◽

Pathological Process ◽

Fundamental Factor ◽

Sinus Mucosa ◽

Morphological State

The work carried out made it possible to substantiate the need to apply a method for studying the frequency of beating of cilia of the mucous membrane of the nasal cavity and paranasal sinuses in patients with chronic rhinosinusitis when choosing treatment tactics in an ENT hospital. Analysis of the study of data on the functional and morphological state of the mucous membrane of the nasal cavity and maxillary sinus allows us to judge the severity of the pathological process before surgery, which is the fundamental factor in the algorithm for the treatment of chronic rhinosinusitis.

Download Full-text