scholarly journals Rapid and efficient synthesis of the penta-peptide of elastin protein and peptides containing highly hindered α,α-dialkyl amino acids employing Fmoc-amino acid chlorides under microwave irradiation in solution phase

ARKIVOC ◽  
2005 ◽  
Vol 2006 (1) ◽  
pp. 21-30 ◽  
Author(s):  
Subramanyam J. Tantry ◽  
R. V. Ramana Rao ◽  
V. V. Suresh Babu
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Microwave Irradiation ◽  
Solution Phase ◽  
Acid Chlorides ◽  
Efficient Synthesis ◽  
Dialkyl Amino Acids

scholarly journals Synthesis of Dianionic and Trianionic Chiral, Chelating Ligands Based on Amino Acids

2008 ◽  
Vol 61 (4) ◽  
pp. 297
Author(s):  
Madeleine Schultz ◽  
Jakov Kulis ◽  
Julie Murison ◽  
Genevieve W. Andrews
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Aspartic Acid ◽  
Nitrilotriacetic Acid ◽  
Solution Phase ◽  
Chelating Ligands ◽  
Bidentate Ligands ◽  
Synthetic Route ◽  
Tridentate Ligands ◽  
Amide Coupling

The synthesis of two new families of amino acid-containing chiral ligands, based on methyliminodiacetic acid and nitrilotriacetic acid cores, has been accomplished using a simple protection, solution-phase amide coupling, and deprotection strategy. The amino acids glycine, leucine, aspartic acid, and phenylalanine were used to demonstrate the versatility of the synthetic route, and that no epimerization occurs. The tridentate ligands bear C3 symmetry, whereas the bidentate ligands have C1 symmetry.

scholarly journals Phosphorus (V) porphyrin diaxially substituted with Leu-enkephalin

2004 ◽  
Vol 2 (3) ◽  
pp. 446-455 ◽  
Author(s):  
Mariusz Gajewski ◽  
Leszek Czuchajowski
Keyword(s):  
Amino Acids ◽  
Photodynamic Therapy ◽  
Amino Acid ◽  
Biologically Active ◽  
Solution Phase ◽  
Terminal Amino Acid ◽  
Leucine Enkephalin ◽  
Potential Applications ◽  
Biologically Active Peptide ◽  
Terminal Amino

AbstractSynthesis of the first phosphorus (V) porphyrin-peptide conjugate was successfully accomplished. A biologically active peptide, leucine enkephalin, was constructed on the phosphorus atom of the 5,10,15,20-meso-tetraphenylporphinato dichlorophosphorus (V) chloride. The method involved solution phase peptide synthesis. The first C-terminal amino acid in the sequence of the peptide was axially attached to the porphyrin through a linker, 3-aminopropanol, and the remainder of leucine enkephalin was synthesized by subsequent additions of amino acids. Leucine enkephalin-P(V) porphyrin conjugate represents a new group of compounds, and its synthesis broadens potential applications of P(V) porphyrine, e.g. in photodynamic therapy.

Metallkomplexe mit biologisch wichtigen Liganden, XXXIII. Reaktionen von α-Aminosäuren und α-Aminosäurederivaten mit Gold(III)-chlorid/ Metal Complexes with Biological Important Ligands, XXXIII. Reactions of α-Amino Acids and Derivatives there of with Gold(III) Chloride

1984 ◽  
Vol 39 (8) ◽  
pp. 1129-1134 ◽  
Author(s):  
Eberhard Ambach ◽  
Mano Mohan Singh ◽  
Ulrich Nagel ◽  
Wolfgang Beck
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Metal Complexes ◽  
Thionyl Chloride ◽  
Ammonium Salts ◽  
Acid Chlorides ◽  
X Ray ◽  
Amino Acids And Derivatives ◽  
Acid Anhydrides

AbstractThe hydrochlorides of a-aminoacid esters react with Au2Cl6 in thionyl chloride to give the ammonium salts [H3NCHRCO2R′]+AuCl4- (R = H , Me, R′ = H , Me, Et). The X-ray structure of [H3NCH(Me)CO2Me]+AuCl4- has been determined. The reactions of a-aminoacids with Au2Cl6 in SOCl2 afford mixtures of ammonium tetrachloroaurate(III) salts with a-amino acids, a-amino acid chlorides or a-amino acid anhydrides as amine components. Cysteine esters reduce gold(III) to give the gold(I) compounds [AuSCH2CH(N H2)CO2R]n (R = Me, Et).

Gram-Scale Solution-Phase Synthesis of Heptapeptide Side Chain of Teixobactin

Synlett ◽  
2019 ◽  
Vol 30 (20) ◽  
pp. 2268-2272 ◽  
Author(s):  
Sangeetha Donikela ◽  
Kiranmai Nayani ◽  
Vishnuvardhan Nomula ◽  
Prathama S. Mainkar ◽  
Srivari Chandrasekhar
Keyword(s):  
Amino Acids ◽  
Amino Acid ◽  
Natural Product ◽  
Solution Phase ◽  
Side Chain ◽  
Phase Synthesis ◽  
Solution Phase Synthesis ◽  
Efficient Coupling ◽  
Scalable Synthesis

We report herein a scalable synthesis of linear heptapeptide side chain of the depsipeptide natural product teixobactin through solution phase. The synthesis of heptapeptide was achieved through an efficient coupling of suitably protected tripeptide and tetrapeptide comprising of three d-amino acids and four usual l-amino acid subunits.

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