scholarly journals Pharmacological studies on disopyramide in experimental arrhythmia. With special reference to effects on cardiovascular system and central nervous system.

1988 ◽  
Vol 19 (1) ◽  
pp. 73-74
Author(s):  
HIROMI MATSUDA
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Special Reference ◽  
Cardiovascular System ◽  
Pharmacological Studies ◽  
Experimental Arrhythmia

Neuropharmacological Profile and Chemical Analysis of Moroccan Ormenis mixta L.

2018 ◽  
Vol 16 (S1) ◽  
pp. S55-S64
Author(s):  
G. Hajjaj ◽  
A. Bahlouli ◽  
M. Tajani ◽  
K. Alaoui ◽  
Y. Cherrah ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Body Weight ◽  
Traditional Medicine ◽  
Behavioral Tests ◽  
Phytochemical Screening ◽  
Activity Profile ◽  
Acute Toxicity Study ◽  
Pharmacological Studies

Ormenis mixta L. is traditionally used for central nervous system (CNS)-related diseases. Its anti-stress properties have received attention in Moroccan traditional medicine and aromatherapy. However, no pharmacological studies have yet been undertaken on this plant in Morocco. The present study provides a preliminary phytochemical screening and psychopharmacological profile of the essential oil and aqueous extract from Ormenis mixta L. by using behavioral tests in vivo, at graded doses. The result of this research shows that Ormenis mixta L. was safe up to 2 g/kg b.w. (body weight) in the acute toxicity study, possesses potential psychostimulant effect, and has antianxiety and antidepressant-like activity. This activity profile of Ormenis mixta L. was similar to the typical psychostimulant, caffeine. The exact mechanism of action underlying this stimulant-like effect should be clarified with further detailed studies. These results explained the extensive use of Ormenis mixta L. as a traditional medicine in Morocco.

Influence of central nervous system on arterial pressure during endotoxin shock

1983 ◽  
Vol 244 (2) ◽  
pp. H178-H185
Author(s):  
H. F. Janssen ◽  
L. O. Lutherer
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Mean Arterial Pressure ◽  
Arterial Pressure ◽  
Cardiovascular System ◽  
Endotoxin Shock ◽  
Shock State ◽  
Induced Hypotension ◽  
Ventriculocisternal Perfusion

Some investigators have suggested that the hypotensive effects of endotoxin are exerted at the level of central nervous system (CNS). Others feel the effects are exerted peripherally and that the CNS is involved in the regulation of the cardiovascular system during the shock state. Still other data suggest that endotoxin shock is entirely a peripheral phenomenon. The present study used ventriculocisternal perfusion of endotoxin, a pretrigeminal brainstem transection, two midcollicular decerebrate preparations, and Cushing's reflex to investigate the involvement of the CNS during endotoxin shock. The results suggest the following: 1) endotoxin perfused centrally at a concentration equivalent to the maximum obtainable after peripheral injection will not alter mean arterial pressure (MAP); 2) either the forebrain is not involved in the MAP response or the remaining regions can compensate for its absence; and 3) Cushing's reflex will block the initial endotoxin-induced hypotension.

Musculoskeletal injuries in children

2011 ◽  
Author(s):  
Tim Theologis
Keyword(s):  
At Risk ◽  
Central Nervous System ◽  
Nervous System ◽  
Cardiovascular System ◽  
Musculoskeletal Injuries ◽  
Characteristic Pattern ◽  
Growth Disturbance ◽  
Hypovolaemic Shock ◽  
The Central Nervous System ◽  
K Wires

♦ In children, bone is more flexible and heals faster than in adults but is at risk of growth disturbance. It is also capable of remodelling♦ The physis is weaker than the structures around it and therefore is liable to disruption in trauma♦ The possibility of injuries as a result of abuse must be considered in children and have a characteristic pattern♦ In poly trauma, children are more susceptible to hypothermia. Abdominal viscera and the cranium are more vulnerable. However, the central nervous system has more scope for recovery, and the cardiovascular system has an excellent capacity for coping with hypovolaemic shock♦ A reliable specific paediatric score should be used to plan treatment♦ The management of fractures is more likely to involve traction, plaster, and K-wires.

Effect of Epinephrine on Central Nervous System and Cardiovascular System Toxicity of Bupivacaine in Pigs

1989 ◽  
Vol 71 (5) ◽  
pp. 711-717 ◽  
Author(s):  
Christopher M. Bernards ◽  
Randall L. Carpenter ◽  
Mark E. Kenter ◽  
David L. Brown ◽  
Stephen M. Rupp ◽  
...  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Cardiovascular System ◽  
System Toxicity
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