Development and Characterization of β- Tricalcium Phosphate Cements Containing Chitosan

In order to improvedβ-TCP biocompatibility and cell growth, was chosen to modify β-TCP matrices to produce a γ-PGA/β-TCP composite biomaterial. Then, the morphology, water uptake and retention abilities,in vitrodegradation property in the simulated medium, cytotoxicity of this novel γ-PGA/β-TCP composite is investigated. SEM shows that the γ-PGA/β-TCP composite has a porous structure. By increasing the percentage ofγ-PGA from 0% to 50%, the swelling ratio of the composite s was enhanced from 9.0%to 297%. These data suggested that the surface hydrophilicity, water absorption rate, and swelling ratio were improved by adding γ-PGA to the composite. In the cytocompatibility test, the density of MC3T3-E1 preosteoblasts cells on the PTCP1:1 leachates was almost 110% higher than that on the controls on day 3. Therefore, the γ-PGA/β-TCP composite scaffolds, due to their better hydrophilicity, cytocompatibility, and porous structure, are very promising biomaterials for tissure engineering applications.

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Synthesis and characterization of sintered beta-tricalcium phosphate: A comparative study on the effect of preparation route

Materials Science and Engineering C ◽

10.1016/j.msec.2016.05.029 ◽

2016 ◽

Vol 67 ◽

pp. 345-352 ◽

Cited By ~ 15

Author(s):

Rupita Ghosh ◽

Ritwik Sarkar

Keyword(s):

Comparative Study ◽

Tricalcium Phosphate ◽

Synthesis And Characterization ◽

Beta Tricalcium Phosphate ◽

Preparation Route

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Synthesis and Characterization of β-Tricalcium Phosphate Derived From Haliotis sp. Shells

Implant Dentistry ◽

10.1097/id.0000000000000559 ◽

2017 ◽

Vol 26 (3) ◽

pp. 378-387 ◽

Cited By ~ 3

Author(s):

Kyeong-Rok Kang ◽

Zheng-Gang Piao ◽

Jae-Sung Kim ◽

In-A Cho ◽

Min-Ji Yim ◽

...

Keyword(s):

Tricalcium Phosphate ◽

Synthesis And Characterization

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Preparation and Characterization of β-Tricalcium Phosphate Powders with High Solubility for Chelate-Setting Calcium-Phosphate Cements

Key Engineering Materials ◽

10.4028/www.scientific.net/kem.758.194 ◽

2017 ◽

Vol 758 ◽

pp. 194-198

Author(s):

Kohei Nagata ◽

Toshiisa Konishi ◽

Michiyo Honda ◽

Mamoru Aizawa

Keyword(s):

Tricalcium Phosphate ◽

Single Phase ◽

Inositol Phosphate ◽

Heating Temperature ◽

Japanese Industrial Standard ◽

Bone Filler ◽

Setting Mechanism ◽

Median Particle

We have previously developed a novel chelate-setting β-tricalcium phosphate (β-TCP) cement with non-fragmentation property in vivo. This novel cement has been set on the basis of chelate-setting mechanism of inositol phosphate (IP6). In this study, β-TCP powders were synthesized by mechanochemical method, and the as-prepared powders were heated at 600-1300°C for 1 h. Some properties of the resulting powders were examined. The crystalline phase of the resulting powders in the range of 600-1100°C was of β-TCP single phase. In the cases at 1200°C and 1300°C, the resulting powders were composed of β-TCP and α-TCP. Median particle sizes of the resulting powders increased with heating temperature from 5.35 μm up to 47.7 μm. Dissolution rate of Ca2+ ions from the β-TCP powders was measured by Japanese Industrial Standard T 0330-3. When the heating temperature was at 700°C, the Ca2+ ions solubility was highest among examined ones. The β-TCP powder heated at 700°C for 1 h will be expected as the starting powder for paste-like artificial bone filler with excellent bioresorbability.

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