A Brief Discussion on Nucleophilic Substitution Reaction on Saturated Carbon Atom

2013 ◽  
Vol 312 ◽  
pp. 433-437 ◽  
Author(s):  
Yan Ding
Keyword(s):  
Reaction Mechanism ◽  
Carbon Atom ◽  
Nucleophilic Substitution ◽  
Functional Groups ◽  
Organic Synthesis ◽  
Substitution Reaction ◽  
Functional Group ◽  
Hydrolysis Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Saturated Carbon Atom

Nucleophilic substitution reaction is an important reaction of haloalkane. By such a reaction, halogen functional group can turn into various other functional groups. Therefore, it is widely used in organic synthesis and there are many researches on its reaction mechanism. Hydrolysis reaction of bromoalkane is especially a nucleophilic substitution reaction that is studied quite fully. This paper mainly discusses the nucleophilic substitution reaction on saturated carbon atom.

Sterically Unprotected Nucleophilic Boron Cluster Reagents

2019 ◽  
Author(s):  
Xin Mu ◽  
Jonathan C. Axtell ◽  
Nicholas Bernier ◽  
Kent Kirlikovali ◽  
Dahee Jung ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Organic Synthesis ◽  
Substitution Reaction ◽  
Main Group ◽  
Cluster Anion ◽  
Nucleophilic Substitution Reaction ◽  
Boron Cluster

Herein, we demonstrate that the bench stable <i>closo</i>-hexaborate cluster anion can engage in a nucleophilic substitution reaction with a wide array of organic and main group electrophiles. The resulting molecules containing B‒C bonds can be further converted to tricoordinate boron species widely used in organic synthesis.<br>

Nucleophilic substitution reaction for rational post-functionalization of polyoxometalates

2016 ◽  
Vol 40 (2) ◽  
pp. 906-909 ◽  
Author(s):  
Qiang Li ◽  
Jin Zhang ◽  
Longsheng Wang ◽  
Jian Hao ◽  
Panchao Yin ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Functional Groups ◽  
Hybrid Materials ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Substitution Reactions ◽  
Organic Hybrid ◽  
Post Functionalization

Substitution reactions of polyoxometalate–organic hybrid materials provide a post-functionalization protocol to bring in various additional functional groups.

Efficient Monofluoroalkylation of Thiophenols or Phenols with α-Bromo-α-Fluoroketones under Mild Conditions

Synthesis ◽  
2021 ◽  
Author(s):  
Jingjing Wu ◽  
Fanhong Wu ◽  
Zhi Li ◽  
Mougui Fang ◽  
Yunli Liu ◽  
...  
Keyword(s):  
Phenolic Compounds ◽  
Nucleophilic Substitution ◽  
Substitution Reaction ◽  
Functional Group ◽  
Nucleophilic Substitution Reaction ◽  
Mild Conditions ◽  
Broad Scope ◽  
Natural Phenolic Compounds

AbstractAn efficient nucleophilic substitution reaction between α-bromo-α-fluoroketones and thiophenols or phenols is reported for the synthesis of α-fluoro-β-ketosulfides or α-fluoro-β-ketone ethers in yields ranging from 78–93%. This method exhibits good functional group tolerance and a broad scope of nucleophilic substrates, including natural phenolic compounds.

Sterically Unprotected Nucleophilic Boron Cluster Reagents

2019 ◽  
Author(s):  
Xin Mu ◽  
Jonathan C. Axtell ◽  
Nicholas Bernier ◽  
Kent Kirlikovali ◽  
Dahee Jung ◽  
...  
Keyword(s):  
Nucleophilic Substitution ◽  
Organic Synthesis ◽  
Substitution Reaction ◽  
Main Group ◽  
Cluster Anion ◽  
Nucleophilic Substitution Reaction ◽  
Boron Cluster

Herein, we demonstrate that the bench stable <i>closo</i>-hexaborate cluster anion can engage in a nucleophilic substitution reaction with a wide array of organic and main group electrophiles. The resulting molecules containing B‒C bonds can be further converted to tricoordinate boron species widely used in organic synthesis.<br>

scholarly journals Synthesis of Carbohydrate Based Macrolactones and Their Applications as Receptors for Ion Recognition and Catalysis

Molecules ◽  
2021 ◽  
Vol 26 (11) ◽  
pp. 3394
Author(s):  
Surya B. Adhikari ◽  
Anji Chen ◽  
Guijun Wang
Keyword(s):  
Nucleophilic Substitution ◽  
Supramolecular Chemistry ◽  
Copper Sulfate ◽  
Substitution Reaction ◽  
Biological Properties ◽  
Anion Binding ◽  
Nucleophilic Substitution Reaction ◽  
Binding Properties ◽  
Intramolecular Nucleophilic Substitution ◽  
Leaving Groups

Glycomacrolactones exhibit many interesting biological properties, and they are also important in molecular recognitions and for supramolecular chemistry. Therefore, it is important to be able to access glycomacrocycles with different sizes and functionality. A new series of carbohydrate-based macrocycles containing triazole and lactone moieties have been designed and synthesized. The synthesis features an intramolecular nucleophilic substitution reaction for the macrocyclization step. In this article, the effect of some common sulfonate leaving groups is evaluated for macrolactonization. Using tosylate gave good selectivity for monolactonization products with good yields. Fourteen different macrocycles have been synthesized and characterized, of which eleven macrocycles are from cyclization of the C1 to C6 positions of N-acetyl D-glucosamine derivatives and three others from C2 to C6 cyclization of functionalized D-glucosamine derivatives. These novel macrolactones have unique structures and demonstrate interesting anion binding properties, especially for chloride. The macrocycles containing two triazoles form complexes with copper sulfate, and they are effective ligands for copper sulfate mediated azide-alkyne cycloaddition reactions (CuAAC). In addition, several macrocycles show some selectivity for different alkynes.

Lewis-Acid-Catalyzed Direct Nucleophilic Substitution Reaction of Alcohols for the Functionalization of Aromatic Amines

2019 ◽  
Vol 4 (4) ◽  
pp. 1371-1374 ◽  
Author(s):  
Onkar S. Nayal ◽  
Maheshwar S. Thakur ◽  
Rohit Rana ◽  
Rahul Upadhyay ◽  
Sushil K. Maurya
Keyword(s):  
Nucleophilic Substitution ◽  
Lewis Acid ◽  
Aromatic Amines ◽  
Substitution Reaction ◽  
Nucleophilic Substitution Reaction ◽  
Acid Catalyzed
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