Efficient Monofluoroalkylation of Thiophenols or Phenols with α-Bromo-α-Fluoroketones under Mild Conditions
Keyword(s):
AbstractAn efficient nucleophilic substitution reaction between α-bromo-α-fluoroketones and thiophenols or phenols is reported for the synthesis of α-fluoro-β-ketosulfides or α-fluoro-β-ketone ethers in yields ranging from 78–93%. This method exhibits good functional group tolerance and a broad scope of nucleophilic substrates, including natural phenolic compounds.
2013 ◽
Vol 312
◽
pp. 433-437
◽
2011 ◽
Vol 4
(3)
◽
pp. 281-287
◽
1993 ◽
Vol 115
(13)
◽
pp. 5879-5880
◽
2013 ◽
Vol 448
◽
pp. 74-80
◽