Synthesis and In Vitro Anti-Inflammatory Activity of Pyrrolo[1,2-A]pyrazines via Pd-Catalyzed Intermolecular Cyclization Reaction
2013 ◽
Vol 830
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pp. 115-118
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Keyword(s):
Pyrrolo [1,2-a] pyrazine possessed widely bioactivities due to its particular structure. In this work, three pyrrolo [1,2-a] pyrazines derivatives were synthesized from the 2-bromo-5-methoxypyrazine and propargyl amines or ethers through the Pd-catalyzed intermolecular cycloisomerization strategy. Their structures were characterized by NMR, IR, EI-MS and elemental analysis, and all of them exhibited moderatein vitroanti-inflammatory effects with the inhibitions of 43-59% against IL-6 at 50 μM. The compound3crevealed relatively good anti-inflammatory activities. The bioactive pyrrolo [1,2-a] pyrazines might be potentially used as anti-inflammatory agents.
2008 ◽
Vol 10
(1)
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pp. 49-53
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2014 ◽
Vol 9
(11)
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pp. 1934578X1400901
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2017 ◽
Vol 9
(6)
◽
pp. 145