scholarly journals Synthesis of Silver (I) Coordination of Aspirinate Azo Ligands as Potential Antibacterial Agents

2021 ◽  
Vol 411 ◽  
pp. 17-24
Author(s):  
Nur Arif Mortadza ◽  
Zainab Ngaini ◽  
Maya Asyikin Mohamad Arif

The rise of antimicrobial resistance for infectious bacteria has become an alarming issue to human health. New antimicrobial drugs are in dire need and pivotal to overcome this issue. In this study, aspirinate azo ligands bearing different halogens L1-5 has been prepared via diazo-coupling reaction. The ligands L1-5 were coordinated with silver, Ag (I) metal to produce Ag (I) aspirin-azo complexes C1-5. The antibacterial properties of L1-5 and C1-5 were evaluated against Staphylococcus aureus and Escherichia coli using turbidimetric kinetic method. The complexes C1-5 showed comparable growth inhibition activity towards E. coli (MIC 82-105 ppm) and S. aureus (MIC 80-105 ppm) compared to ligands L1-5 with E. coli (MIC 83-200 ppm), S. aureus (80-131 ppm) and ampicillin (MIC 93 and 124 ppm, respectively). The excellent bacterial resistance of both L1-5 and C1-5 indicates the potential of aspirinate azo and their complexes as new antibacterial agents, which significantly benefit to the pharmaceutical industries.

2011 ◽  
Vol 22 (2) ◽  
pp. 279-285 ◽  
Author(s):  
Sueny K. B Freitas ◽  
Valdinete Lins da Silva ◽  
Alberto N Araújo ◽  
Maria Conceição B. S. M Montenegro ◽  
Boaventura F Reis ◽  
...  

2016 ◽  
Vol 230 (2) ◽  
Author(s):  
Caihong Chen ◽  
Zhening Yang ◽  
Fengxian Qiu ◽  
Tianlin Cao ◽  
Guorong Cao ◽  
...  

AbstractAn azo chromophore molecular S(-)-1,2-bis(4-azophenyl-4-nitro)-ethylenediamine (OABANEDA) was synthesized with 4-nitroaniline and S(-)-1,2-diphenyl ethylenediamine by diazo-coupling reaction. The azo polyurethane-urea (OAAPUU) was obtained from OABANEDA, polyether diol (NJ-210) and isophorone diisocyanate (IPDI). The structure of OAAPUU was characterized by the Fourier transform infrared and UV-visible spectroscopy. The physical and mechanical properties of OAAPUU were investigated. The refractive index (


1991 ◽  
Vol 40 (8) ◽  
pp. 377-381
Author(s):  
Yuji SUZUKI ◽  
Yoshikatsu SAKAGISHI

1961 ◽  
Vol 7 (6) ◽  
pp. 603-625 ◽  
Author(s):  
Derek Watson

Abstract A critical evaluation of existing colorimetric and spectrophotometric methods for the determination of bilirubin in blood plasma is presented. The stoichiometric equivalences of the reagents used in the diazo coupling reaction are re-evaluated. The elimination of turbidity is discussed, as well as methods using diazo-coupling promoters. Recommendations are made concerning the preservation of specimens to prevent oxidation and procedures that give maximal specificity for the type of bilirubin pigment being assayed.


1974 ◽  
Vol 47 (9) ◽  
pp. 2351-2352 ◽  
Author(s):  
Hideo Yamada ◽  
Y\={o}ji Hashida ◽  
Shizen Sekiguchi ◽  
Kohji Matsui

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