Effect of Microstructure on Osteoinductivity of Biomaterials

2005 ◽  
Vol 284-286 ◽  
pp. 289-292 ◽  
Author(s):  
Ji Yong Chen ◽  
You Rong Duan ◽  
Xing Dong Zhang
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Animal Experiments ◽  
Apatite Layer ◽  
Apatite Formation ◽  
Calcium Phosphate Ceramics ◽  
Group A ◽  
Group B ◽  
Group D ◽  
Porous Biphasic Calcium Phosphate

Two sets of porous biphasic calcium phosphate ceramics (BCP) were prepared for dynamic SBF experiment: porous BCP with micropores on the walls of macropores( set A) and porous BCP with dense walls of macropores (set B). Apatite layer could only formed on the macropore walls with micropores. Four groups of specimens were prepared for animal experiments. Group A was porous BCP ceramics with micropores on the walls of macropores; group B was porous BCP with dense walls of macropores; group C was porous BCP ceramics with apatite layers formed by static SBF[2]on their surfaces; group D was porous BCP ceramics with apatite layers formed by dynamic SBF on their walls of macropores. The result of dynamic SBF animal experiments showed that microstructure of BCP played an important role in the bone-like apatite formation and osteoinductiion in biomaterials. Apatite formation may be the prerequisite of osteoinductive formation of new bone.

Study of Bio-Mineralization of BCP with Compensation of Calcium and Phosphate Ions

2009 ◽  
Vol 610-613 ◽  
pp. 1391-1394
Author(s):  
Hua De Zheng ◽  
Ying Jun Wang ◽  
Qiang Ma ◽  
Cheng Yun Ning ◽  
Xiao Feng Chen
Keyword(s):  
Free Energy ◽  
Calcium Phosphate ◽  
Calcium Ions ◽  
Biphasic Calcium Phosphate ◽  
Porous Ceramic ◽  
Apatite Layer ◽  
Apatite Formation ◽  
Phosphate Ions

In the present study, an Intelligent Multi-parameter Simulated Evaluation in vitro （IMSE system） was used to study the deposition properties of apatite formation on the surface of biphasic calcium phosphate porous ceramic (BCP) from static and dynamic r-SBF. Results showed that apatite formed on the surface of BCP from static and dynamic r-SBF differed between each other. In static r-SBF, ions were transferred by diffusion, which could not compensate the consuming of calcium ions, and mist apatite layer was formed on the surface of samples. But in the dynamic r-SBF, simulated fluid was adjusted precisely and flowed forcedly, the concentrations of ions were homogeneous; with the compensation of ions, calcium and phosphate were supersaturated, and the free energy of apatite formation was negative, bone-like apatite sheets were formed on the surface of samples.

RETRACTED: Effect of nanostructure on osteoinduction of porous biphasic calcium phosphate ceramics

2012 ◽  
Vol 8 (10) ◽  
pp. 3794-3804 ◽  
Author(s):  
Bo Li ◽  
Xiaoling Liao ◽  
Li Zheng ◽  
Xiangdong Zhu ◽  
Zhe Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramics ◽  
Porous Biphasic Calcium Phosphate

Flow Perfusion Culture of Marrow Stromal Cells Seeded on Porous Biphasic Calcium Phosphate Ceramics

2005 ◽  
Vol 33 (9) ◽  
pp. 1238-1248 ◽  
Author(s):  
Heidi L. Holtorf ◽  
Tiffany L. Sheffield ◽  
Catherine G. Ambrose ◽  
John A. Jansen ◽  
Antonios G. Mikos
Keyword(s):  
Calcium Phosphate ◽  
Stromal Cells ◽  
Biphasic Calcium Phosphate ◽  
Perfusion Culture ◽  
Marrow Stromal Cells ◽  
Calcium Phosphate Ceramics ◽  
Flow Perfusion ◽  
Porous Biphasic Calcium Phosphate

Evaluation of Porous Biphasic Calcium Phosphate Ceramics for Anterior Cervical Interbody Fusion in a Caprine Model

Spine ◽  
1995 ◽  
Vol 20 (Supplement) ◽  
pp. 2203-2210 ◽  
Author(s):  
Jeffrey M. Toth ◽  
Howard S. An ◽  
Tae-Hong Lim ◽  
Yujun Ran ◽  
Nicholas G. Weiss ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Biphasic Calcium Phosphate ◽  
Interbody Fusion ◽  
Calcium Phosphate Ceramics ◽  
Porous Biphasic Calcium Phosphate

scholarly journals In vitro and in vivo assessment of nanostructured porous biphasic calcium phosphate ceramics for promoting osteogenesis in an osteoporotic environment

RSC Advances ◽  
2018 ◽  
Vol 8 (26) ◽  
pp. 14646-14653 ◽  
Author(s):  
Kun Zhang ◽  
Jieyu Zhang ◽  
Kelei Chen ◽  
Xuefeng Hu ◽  
Yunbing Wang ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Bone Defect ◽  
Biphasic Calcium Phosphate ◽  
Calcium Phosphate Ceramics ◽  
Defect Healing ◽  
Bone Defect Healing ◽  
In Vivo Assessment ◽  
Porous Biphasic Calcium Phosphate

Nanostructured porous biphasic calcium phosphate ceramics are able to significantly promote bone defect healing in an osteoporotic environment.

Biological Performance of Dental Biphasic Calcium Phosphate Ceramics Modified by Cold Plasma

2008 ◽  
Vol 368-372 ◽  
pp. 1264-1267 ◽  
Author(s):  
Bao Hui Su ◽  
Jing Chun Su ◽  
Jun Guo Ran ◽  
Bao Yue Su
Keyword(s):  
Cell Proliferation ◽  
Calcium Phosphate ◽  
Cold Plasma ◽  
Biphasic Calcium Phosphate ◽  
C2c12 Cell ◽  
Apatite Formation ◽  
Calcium Phosphate Ceramics ◽  
Plasma Technique ◽  
Biological Performance

HA/ß-TCP is one kind of important bone tissue engineering scaffold materials. In order to improve the biological performance of materials, HA/ß-TCP ceramics were modified by the cold plasma technique in this paper. The biological performances of treated materials were evaluated by the results of bone-like apatite formation in SBF, the coculture of the C2C12 cell line and HA/ß-TCP, cell proliferation experiments, observations of the electron microscopy and fluorescence staining and the animal intramuscular implantation experiments. The results showed that after immersion, compared with untreated HA/ß-TCP, treated materials were more conducive to form bone-like apatite; modified HA/ß-TCP could promote the cell proliferation more; the cells grew in the course of nature on the treated scaffold and modified HA/ß-TCP had better bone-forming performance in vivo. It was concluded that modified HA/ß-TCP had better biological performance; the cold plasma technique could improve the biological performance of dental biphasic calcium phosphate ceramics.

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