Thin Sol-Gel Films on Fracture Fixation Material for the Controlled Release of Antibiotics

2006 ◽  
Vol 309-311 ◽  
pp. 759-762 ◽  
Author(s):  
Shula Radin ◽  
Javad Parvizi ◽  
Paul Ducheyne
Keyword(s):  
Controlled Release ◽  
Fracture Fixation ◽  
Room Temperature ◽  
Sol Gel ◽  
Processing Parameters ◽  
Silica Sol ◽  
Great Promise ◽  
Bone Infections ◽  
Sol Gel Films

Previously, the properties of room temperature processed silica sol gel (also called xerogels) as resorbable and biocompatible controlled release systems were described. It was demonstrated that drugs and macromolecules with a variety of properties and characteristics could be released in a controlled manner. In this study, we focus on the synthesis of antibacterial thin solgel films on intramedullary nails and fracture fixation materials. We determine the effect of processing parameters on the in vitro properties and demonstrated a time- and load- dependent release of vancomycin from the film. This study suggests that thin sol-gel films hold great promise for the prevention and treatment of bone infections.

Emulsified Sol-Gel Microspheres for Controlled Drug Delivery

2007 ◽  
Vol 330-332 ◽  
pp. 1025-1028
Author(s):  
Shula Radin ◽  
T.L. Chen ◽  
Paul Ducheyne
Keyword(s):  
Controlled Release ◽  
Room Temperature ◽  
Sol Gel ◽  
In Vitro Release ◽  
Processing Parameters ◽  
Short Term ◽  
Acid Catalyzed ◽  
Vitro Release

Controlled release silica sol-gels are room temperature processed, porous, resorbable, and biocompatible materials. Many molecules including drugs, proteins, and growth factors can be released from sol-gels, and the quantity and duration of the release can vary widely. Processing parameters render these release properties exquisitely versatile [1]. The synthesis of controlled release sol-gels involves several steps: an acid-catalyzed hydrolysis to form a sol with the molecules included, followed by casting, aging, and drying. Additional steps such as grinding and sieving are required to produce sol-gel granules of a desirable size. In this study, we focus on the synthesis of controlled release sol-gel microspheres by using a novel process, which involves only two steps:sol formation followed by emulsification. Sol-gel microspheres containing either vancomycin (antibiotic) or bupivacaine (analgesic) were successfully synthesized via this synthesis route. Both drugs showed controlled, load-dependent and time-dependent release from the microspheres. The in vitro release properties of sol-gel microspheres were different from those of sol-gel granules produced by grinding and sieving. In comparison to a fast, short-term release from the granules, the release from the microspheres was slower and of longer duration. In addition, the degradation rate of microspheres was significantly slower than that of the granules. These data enable the use of sol-gel powders for controlled long-term release.

In Vitro and In Vivo Bactericidal Effect of Sol-Gel/Antibiotic Thin Films on Fixation Devices

2007 ◽  
Vol 330-332 ◽  
pp. 1323-1326
Author(s):  
Shula Radin ◽  
V. Antoci ◽  
N. Hickok ◽  
Christopher S. Adams ◽  
Javad Parvizi ◽  
...  
Keyword(s):  
Sol Gel ◽  
Processing Parameters ◽  
Bactericidal Effect ◽  
Great Promise ◽  
Bactericidal Effects ◽  
Gel Film ◽  
Sol Gel Films ◽  
Degradation Properties

Beneficial properties of room temperature processed silica sol-gels as resorbable and biocompatible materials for the controlled release of drugs and macromolecules have been described before. Recently, it was shown that a thin sol-gel film can be used for the controlled delivery of antibiotics such as vancomycin. It was also demonstrated that the release and degradation properties of the sol-gel films can be tailored via processing parameters. In this work, we evaluated the in vitro and in vivo bactericidal effects of vancomycin-containing thin sol-gel films applied on Ti-alloy intramedullary nails. Both the in vitro and the in vivo results demonstrate a pronounced bactericidal effect of the sol-gel/antibiotic films. This study suggests that thin antibiotic-containing sol-gel film holds great promise for the prevention and treatment of bone infections.

Crack Filling of Cover Glasses by Sol-Gel Coatings

2013 ◽  
Vol 797 ◽  
pp. 700-705 ◽  
Author(s):  
Kung Jeng Ma ◽  
Hsi Hsin Chien ◽  
Su Wei Huang ◽  
Shi Chang Chen ◽  
Choung Lii Chao
Keyword(s):  
Sol Gel ◽  
Smart Phone ◽  
Processing Parameters ◽  
Silica Sol ◽  
Coating Process ◽  
Cover Glass ◽  
Roll Coating ◽  
High Penetration ◽  
Glass Plates ◽  
Resistant Layer

Strengthening of glass sheets through the process of ion exchange have been widely used in thinner cover glass for smart phone. The compressive stress improves the ability of the glass surface to withstand damage from mechanical impact. However, the presence of the damage resistant layer makes conventional mechanical and laser cutting of the ion-exchanged glass difficult. Normally, the cutting process will lead to spontaneous glass sheet breakage or shattering. Even successful in some samples, the underlying central tension is exposed on the edge, and the mechanical strength and durability of this edge is degraded. The repair of edge cracks becomes an extremely important issue for the development of single glass based smart phone. The ion exchanged glass plates (Corning IOX-FS) with a thickness of 0.7 mm were selected as the substrate materials. After cutting ion exchanged glass by high penetration diamond scribing wheels, the edge of glass plates can be protected or strengthened with silica sol using roll coating process. It was observed that the strength could be improved achieving 210 % compared to the strength of uncoated glass sheets. The sol-gel coating could improve the strength of the glass mainly by the mechanisms of filling in edge flaws or blunting crack tips. The effects of silica sol and processing parameters of roll coating process on the cracks filling effects were investigated.

Silicon dioxide nanotubes prepared by anodic alumina as templates

2000 ◽  
Vol 15 (2) ◽  
pp. 387-392 ◽  
Author(s):  
Ming Zhang ◽  
Y. Bando ◽  
K. Wada
Keyword(s):  
Silicon Dioxide ◽  
Aging Time ◽  
Room Temperature ◽  
Sol Gel ◽  
Silica Sol ◽  
Anodic Alumina ◽  
Template Method ◽  
Nanochannel Array ◽  
Inside Wall ◽  
Dipping Time

Aligned slicon dioxide nanotubes with diameters of 30–40 nm synthesized by the sol-gel template method are presented. This process involves the growth of nanotubes from ordered nanochannel-array pores in anodic alumina. For a silica sol aged at room temperature and dipped for 1 min, nanowires were formed in a shorter period of aging time (2 days); nanotubes connecting with solid nanofibers were obtained in a longer aging time (30 days). The formation of nanotubes depends strongly on the temperature of the sol. For a short dipping time (<1 min), bamboolike nanofibers were prepared when the sol was at high temperature (50 °C); however, perfect nanotubes with the sharp wall were synthetized for the lower sol temperature (5 °C). The lower sol temperature is, the smoother the inside wall of nanotubes is. It is proved that viscosity plays an important role on the morphology of nanotubes.

scholarly journals Triethylphosphite as a network forming agent enhances in vitro biocompatibility and corrosion protection of hybrid organic–inorganic sol–gel coatings for Ti6Al4V alloys

2014 ◽  
Vol 2 (45) ◽  
pp. 7955-7963 ◽  
Author(s):  
A. A. El hadad ◽  
V. Barranco ◽  
A. Jiménez-Morales ◽  
G. J. Hickman ◽  
J. C. Galván ◽  
...  
Keyword(s):  
Corrosion Protection ◽  
Sol Gel ◽  
Silica Sol ◽  
In Vitro Biocompatibility ◽  
Hybrid Silica

Introduction of phosphorous into hybrid silica sol–gel coatings on Ti6Al4V gives materials demonstrating higher levels of intermolecular condensation and fibrinogen uptake as well as improved in vitro biocompatibility and corrosion protection.

Photodegradation of rhodamine 6G dimers in silica sol–gel films

2013 ◽  
Vol 271 ◽  
pp. 93-98 ◽  
Author(s):  
Barbara Lasio ◽  
Luca Malfatti ◽  
Plinio Innocenzi
Keyword(s):  
Rhodamine 6G ◽  
Sol Gel ◽  
Silica Sol ◽  
Sol Gel Films

In Vitro Behavior of Yttrium Silica Sol-Gel Microspheres

2005 ◽  
pp. 411-414
Author(s):  
D. Cacaina ◽  
Reeta Viitala ◽  
Mika Jokinen ◽  
Heimo O. Ylänen ◽  
Mikko Hupa ◽  
...  
Keyword(s):  
Sol Gel ◽  
Silica Sol
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