In Vitro Biocompatibility of a New High Nitrogen Nickel Free Austenitic Stainless Steel

2007 ◽  
Vol 342-343 ◽  
pp. 605-608 ◽  
Author(s):  
Yi Bin Ren ◽  
Hua Juan Yang ◽  
Ke Yang ◽  
Bing Chun Zhang
Keyword(s):  
Stainless Steel ◽  
Austenitic Stainless Steel ◽  
Blood Compatibility ◽  
Platelet Rich Plasma ◽  
Clotting Time ◽  
Adhesion Test ◽  
High Nitrogen ◽  
In Vitro Biocompatibility ◽  
Time Test

The in vitro blood compatibility of a new nickel free high nitrogen austenitic stainless steel Fe-Cr-Mn-Mo-N (BIOSSN4) was studied by the kinetic clotting time test and the platelet rich plasma adhesion test in this paper. In comparison with 316L stainless steel, the kinetic clotting time of BIOSSN4 steel are longer, and only causes less activation of platelets in platelet adhesion test, which was indicated by their morphology and low spreading. The experimental results reveals that the BIOSSN4 stainless steel has better blood compatibility, the blood compatibility mechanism of steels was analyzed based on surface tension and interfacial tension between the steels and blood.

Study of biocompatibility of medical grade high nitrogen nickel-free austenitic stainless steel in vitro

2014 ◽  
Vol 43 ◽  
pp. 641-648 ◽  
Author(s):  
Menghua Li ◽  
Tieying Yin ◽  
Yazhou Wang ◽  
Feifei Du ◽  
Xingzheng Zou ◽  
...  
Keyword(s):  
Stainless Steel ◽  
Austenitic Stainless Steel ◽  
High Nitrogen ◽  
Medical Grade

The Flowing Clotting Time (Thrombus Formation Time) a Sensitive Test of Hypercoagulability

1969 ◽  
Vol 21 (03) ◽  
pp. 516-523
Author(s):  
H Engelberg ◽  
L. P Engelberg
Keyword(s):  
Thrombus Formation ◽  
Formation Time ◽  
Sensitive Test ◽  
Clotting Time ◽  
Reliable Test ◽  
Time Test ◽  
Plasma Heparin

SummaryThe addition of small amounts of extrinsic thromboplastin or of thrombin to blood in vitro accelerated coagulation more frequently and to a greater extent when determined by the flowing time test than when measured by the silicone clotting time, or by the blood or plasma heparin tolerance tests. Similar results were obtained when intrinsic thromboplastin formation was stimulated by contact with glass. However there was little or no acceleration of the flowing clotting time of plasma obtained from aliquots of the thromboplastin-containing blood. These results indicate that the flowing clotting time (thrombus formation time) of whole blcod is a more reliable test of hypercoagulability than previously described blood or plasma clotting time tests.

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