The Role of NF-kappaB in the TNF-alpha-induced Apoptosis of Lung Cancer Cell Line

2000 ◽  
Vol 48 (2) ◽  
pp. 166
Author(s):  
J Y Kim ◽  
S H Lee ◽  
B Hwangbo ◽  
C T Lee ◽  
O H Kim ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Tnf Alpha ◽  
Lung Cancer Cell ◽  
Nf Kappab ◽  
Induced Apoptosis

scholarly journals Role of the CKIP1 gene in proliferation and apoptosis of the human lung cancer cell line H1299

2015 ◽  
Vol 14 (2) ◽  
pp. 4005-4014 ◽  
Author(s):  
G.M. Chen ◽  
R.F. Ding ◽  
Y.D. Tan ◽  
X.B. Pan ◽  
G.M. Jiang ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Human Lung ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Human Lung Cancer ◽  
Lung Cancer Cell ◽  
Proliferation And Apoptosis

scholarly journals Discovery of Inhibitors that Elucidate the Role of UCH-L1 Activity in the H1299 Lung Cancer Cell Line

2003 ◽  
Vol 10 (9) ◽  
pp. 837-846 ◽  
Author(s):  
Yichin Liu ◽  
Hilal A. Lashuel ◽  
Sungwoon Choi ◽  
Xuechao Xing ◽  
April Case ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell

scholarly journals The role of glutathione in resistance to cisplatin in a human small cell lung cancer cell line

1990 ◽  
Vol 62 (1) ◽  
pp. 72-77 ◽  
Author(s):  
C Meijer ◽  
NH Mulder ◽  
GAP Hospers ◽  
DRA Uges ◽  
EGE de Vries
Keyword(s):  
Lung Cancer ◽  
Small Cell Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Small Cell ◽  
Lung Cancer Cell ◽  
Small Cell Lung

Cytotoxic effect induced apoptosis in lung cancer cell line on Ageratina adenophora leaf extract

2019 ◽  
Vol 22 ◽  
pp. 101381
Author(s):  
Suganya Mani ◽  
Karthik Natesan ◽  
Kavitha Shivaji ◽  
Mythili Gnanamangai Balasubramanian ◽  
Ponmurugan Ponnusamy
Keyword(s):  
Lung Cancer ◽  
Cell Line ◽  
Cancer Cell ◽  
Cytotoxic Effect ◽  
Leaf Extract ◽  
Cancer Cell Line ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Ageratina Adenophora ◽  
Induced Apoptosis

scholarly journals Sepia Ink Oligopeptide Induces Apoptosis of Lung Cancer Cells via Mitochondrial Pathway

2018 ◽  
Vol 45 (5) ◽  
pp. 2095-2106 ◽  
Author(s):  
Xiaohua Wang ◽  
Cheng Chen ◽  
Guoren Zhou ◽  
Jinjun Ye ◽  
Rong Yin ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Cell Proliferation ◽  
Cell Line ◽  
Cancer Cell ◽  
Death Receptor ◽  
Cancer Cell Line ◽  
Mitochondrial Pathway ◽  
Lung Cancer Cell Line ◽  
Lung Cancer Cell ◽  
Induced Apoptosis

Background/Aims: Our previous study suggested the anti-tumor activity of sepia ink oligopeptide (SIO). Here we sought to investigate the underlying molecular mechanism. Methods: Cell proliferation was evaluated by cell counting kit-8 (CCK-8) assay. Cell apoptosis was determined by Annexin V/Propidium Iodide (PI) staining. The mitochondria pathway was characterized by quantification of Bcl-2, Bax, Caspase-9 and Cyto-C. The death receptor pathway was analyzed by determinement of Fas, Caspase-8 and NIK. The endoplasmic reticulum (ER)-dependent pathway was determined by measurement the expression of CHOP, Caspase-12, GRP78 and Calpain. The associated gene expression was quantified by RT-PCR and protein level was determined by immunoblotting. Results: We demonstrated treatment with structurally modified SIO (CSIO, 5 µM) significantly inhibited cell proliferation and induced apoptosis in lung cancer cell line A549. The mitochondrial pathway, death receptor pathway and ER stress induced apoptosis were stimulated upon CSIO treatment. The administration with respective inhibitors including midiv-1 (50 µM for 2 h), PDTC (20 µM PDTC for 30 min) and ALLN (20 mM ALLN for 5 h) readily reversed the apoptosis inducing effect of CSIO. Conclusion: Our data demonstrates that CSIO is capable of induction apoptosis in lung cancer cell line, which is mediated by all three classical apoptotic pathways. Our results warrant further in vivo investigations of the anti-tumor potential of CSIO.

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