Identification of TMEM131L as a Novel Regulator of Thymocyte Proliferation in Humans

Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.

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Differential interleukin-1 elaboration by density-defined human monocyte subpopulations

Blood ◽

10.1182/blood.v66.2.298.298 ◽

1985 ◽

Vol 66 (2) ◽

pp. 298-301 ◽

Cited By ~ 14

Author(s):

JA Elias ◽

P Chien ◽

KM Gustilo ◽

AD Schreiber

Keyword(s):

Human Blood ◽

Interleukin 1 ◽

Human Monocyte ◽

Mononuclear Phagocytes ◽

Blood Monocyte ◽

Thymocyte Proliferation ◽

Percoll Gradients ◽

Human Blood Monocyte ◽

Monocytes And Macrophages ◽

Monocyte Subpopulations

Abstract Interleukin-1 (IL-1) is an important immunoregulatory peptide produced by monocytes and macrophages. Because mononuclear phagocytes are morphologically and functionally heterogeneous, we examined whether they differ in their ability to elaborate IL-1. We used discontinuous Percoll gradients to obtain five density-defined human blood monocyte subpopulations. Unfractionated monocytes and their subsets were compared for their ability to stimulate thymocyte proliferation. Supernatants obtained from the denser monocytes consistently contained more IL-1 activity than did supernatants from the less dense cells. This difference in IL-1 activity was the result of differences in IL-1 elaboration, not the selective production of an inhibitor of IL-1- induced thymocyte proliferation. These data demonstrate that density- defined human monocyte subpopulations differ in their capacity to elaborate IL-1.

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Direct manipulation of activator protein-1 controls thymocyte proliferation in vitro

European Journal of Immunology ◽

10.1002/eji.200535215 ◽

2006 ◽

Vol 36 (1) ◽

pp. 160-169 ◽

Cited By ~ 13

Author(s):

Tina M. Thornton ◽

Alfred J. Zullo ◽

Kristi L. Williams ◽

Elizabeth J. Taparowsky

Keyword(s):

Activator Protein 1 ◽

Direct Manipulation ◽

Activator Protein ◽

Thymocyte Proliferation ◽

Proliferation In Vitro

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Tumor necrosis factor (TNF) receptor type 2 mediates thymocyte proliferation independently of TNF receptor type 1

European Journal of Immunology ◽

10.1002/(sici)1521-4141(199801)28:01<257::aid-immu257>3.0.co;2-g ◽

1998 ◽

Vol 28 (1) ◽

pp. 257-263 ◽

Cited By ~ 95

Author(s):

Matthias Grell ◽

Florian M. Becke ◽

Harald Wajant ◽

Daniela N. Männel ◽

Peter Scheurich

Keyword(s):

Tumor Necrosis Factor ◽

Tumor Necrosis ◽

Receptor Type ◽

Tnf Receptor ◽

Thymocyte Proliferation ◽

Necrosis Factor

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Synergism of interleukin 7 with the thymocyte growth factors interleukin 2, interleukin 6, and tumor necrosis factor α in the induction of thymocyte proliferation

Cellular Immunology ◽

10.1016/0008-8749(90)90147-j ◽

1990 ◽

Vol 127 (2) ◽

pp. 470-482 ◽

Cited By ~ 22

Author(s):

Michael P. Everson ◽

John H. Eldridge ◽

William J. Koopman

Keyword(s):

Growth Factors ◽

Tumor Necrosis Factor ◽

Interleukin 6 ◽

Tumor Necrosis ◽

Tumor Necrosis Factor Α ◽

Interleukin 2 ◽

Thymocyte Proliferation ◽

Interleukin 7 ◽

Factor Α ◽

Necrosis Factor

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Pig catabolin is a form of interleukin 1. Cartilage and bone resorb, fibroblasts make prostaglandin and collagenase, and thymocyte proliferation is augmented in response to one protein

Biochemical Journal ◽

10.1042/bj2240461 ◽

1984 ◽

Vol 224 (2) ◽

pp. 461-466 ◽

Cited By ~ 199

Author(s):

J Saklatvala ◽

L M C Pilsworth ◽

S J Sarsfield ◽

J Gavrilovic ◽

J K Heath

Keyword(s):

Articular Cartilage ◽

Prostaglandin E2 ◽

Interleukin 1 ◽

Thymocyte Proliferation

Homogeneous catabolin from pig leucocytes induced proteoglycan breakdown, but not collagen breakdown, in explants of articular cartilage. It augmented lectin-induced proliferation of mouse thymocytes, stimulated production of prostaglandin E2 and collagenase by fibroblasts and chondrocytes, and increased Ca2+ release from mouse calvarial explants, all at concentrations down to 50 pM. In view of these effects it was concluded that pig catabolin is a form of interleukin 1.

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