scholarly journals Recruitment of CTL Activity by Tumor-Specific Antibody-Mediated Targeting of Single-Chain Class I MHC-Peptide Complexes

2002 ◽  
Vol 169 (6) ◽  
pp. 2988-2996 ◽  
Author(s):  
Avital Lev ◽  
Hila Novak ◽  
Dina Segal ◽  
Yoram Reiter
Keyword(s):  
Specific Antibody ◽  
Class I ◽  
Single Chain ◽  
Class I Mhc ◽  
Peptide Complexes ◽  
Ctl Activity

In Vitro Induction of Specific Cytotoxic T Lymphocytes Using Recombinant Single-Chain MHC Class I/Peptide Complexes

1998 ◽  
Vol 21 (4) ◽  
pp. 283-294 ◽  
Author(s):  
Yu-Chun Lone ◽  
Iris Motta ◽  
Estelle Mottez ◽  
Yannik Guilloux ◽  
Annick Lim ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Mhc Class I ◽  
Cytotoxic T Lymphocytes ◽  
Class I ◽  
Single Chain ◽  
Peptide Complexes ◽  
In Vitro Induction

EXPRESSION OF A GPI-ANCHORED, SINGLE-CHAIN ANTIBODY SPECIFIC FOR A CELL DEATH SIGNALING DOMAIN OF HUMAN CLASS I MHC

1998 ◽  
Vol 65 (12) ◽  
pp. S46
Author(s):  
S Kulkami ◽  
J Van Seventer ◽  
N Zhou ◽  
P Holman ◽  
D Kranz ◽  
...  
Keyword(s):  
Cell Death ◽  
Class I ◽  
Single Chain ◽  
Human Class ◽  
Single Chain Antibody ◽  
Class I Mhc ◽  
Signaling Domain ◽  
A Cell ◽  
Cell Death Signaling

CELL-MEDIATED DELIVERY OF PROGRAMMED CELL DEATH SIGNALS FOLLOWING GENE TRANSFER OF A MEMBRANE-ANCHORED SINGLE-CHAIN ANTIBODY SPECIFIC FOR CLASS I MHC

1999 ◽  
Vol 67 (7) ◽  
pp. S212
Author(s):  
S Kulkami ◽  
P Holman ◽  
D Kranz ◽  
G A van Seventer ◽  
J van Seventer ◽  
...  
Keyword(s):  
Cell Death ◽  
Gene Transfer ◽  
Programmed Cell Death ◽  
Class I ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Class I Mhc ◽  
Death Signals

Expression and characterization of recombinant single-chain salmon class I MHC fused with β2-microglobulin with biological activity

2008 ◽  
Vol 24 (4) ◽  
pp. 459-466 ◽  
Author(s):  
Heng Zhao ◽  
René J.M. Stet ◽  
Karsten Skjødt ◽  
Huub F.J. Savelkoul
Keyword(s):  
Biological Activity ◽  
Class I ◽  
Single Chain ◽  
Class I Mhc ◽  
Β2 Microglobulin

EXPRESSION OF A GPI-ANCHORED, SINGLE-CHAIN ANTIBODY SPECIFIC FOR A CELL DEATH SIGNALING DOMAIN OF HUMAN CLASS I MHC

1998 ◽  
Vol 65 (Supplement) ◽  
pp. 122
Author(s):  
S Kulkarni ◽  
J Van Seventer ◽  
N Zhou ◽  
P Holman ◽  
D Kranz ◽  
...  
Keyword(s):  
Cell Death ◽  
Class I ◽  
Single Chain ◽  
Human Class ◽  
Single Chain Antibody ◽  
Class I Mhc ◽  
Signaling Domain ◽  
A Cell ◽  
Cell Death Signaling

Ligand Design for Specific MHC Class I Molecules on the Cell Surface

2020 ◽  
Author(s):  
Xizheng Sun ◽  
Reika Tokunaga ◽  
Yoko Nagai ◽  
Ryo Miyahara ◽  
Akihiro Kishimura ◽  
...  
Keyword(s):  
Cell Surface ◽  
Mhc Class I ◽  
Targeted Delivery ◽  
Peptide Ligands ◽  
Class I ◽  
Class I Mhc ◽  
Mhc I ◽  
Histocompatibility Complex ◽  
High Binding Affinity ◽  
Mhc Class I Molecules

<p><a></a><a></a><a>We have validated that ligand peptides designed from antigen peptides could be used for targeting specific major histocompatibility complex class I (MHC-I)</a> molecules on cell surface. To design the ligand peptides, we used reported antigen peptides for each MHC-I molecule with high binding affinity. From the crystal structure of the peptide/MHC-I complexes, we determined a modifiable residue in the antigen peptides and replaced this residue with a lysine with an ε-amine group modified with functional molecules. The designed ligand peptides successfully bound to cells expressing the corresponding MHC-I molecules via exchange of peptides bound to the MHC-I. We demonstrated that the peptide ligands could be used to transport a protein or a liposome to cells expressing the corresponding MHC-I. The present strategy may be useful for targeted delivery to cells overexpressing MHC-I, which have been observed autoimmune diseases.</p>

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