Assembly and Transport of Class I MHC-Peptide Complexes

2007 ◽  
pp. 150-169
Author(s):  
Peter Cresswell ◽  
Matthew J. Androlewicz ◽  
Bodo Ortmann
Keyword(s):  
Class I ◽  
Class I Mhc ◽  
Peptide Complexes

scholarly journals Recruitment of CTL Activity by Tumor-Specific Antibody-Mediated Targeting of Single-Chain Class I MHC-Peptide Complexes

2002 ◽  
Vol 169 (6) ◽  
pp. 2988-2996 ◽  
Author(s):  
Avital Lev ◽  
Hila Novak ◽  
Dina Segal ◽  
Yoram Reiter
Keyword(s):  
Specific Antibody ◽  
Class I ◽  
Single Chain ◽  
Class I Mhc ◽  
Peptide Complexes ◽  
Ctl Activity

Ligand Design for Specific MHC Class I Molecules on the Cell Surface

2020 ◽  
Author(s):  
Xizheng Sun ◽  
Reika Tokunaga ◽  
Yoko Nagai ◽  
Ryo Miyahara ◽  
Akihiro Kishimura ◽  
...  
Keyword(s):  
Cell Surface ◽  
Mhc Class I ◽  
Targeted Delivery ◽  
Peptide Ligands ◽  
Class I ◽  
Class I Mhc ◽  
Mhc I ◽  
Histocompatibility Complex ◽  
High Binding Affinity ◽  
Mhc Class I Molecules

<p><a></a><a></a><a>We have validated that ligand peptides designed from antigen peptides could be used for targeting specific major histocompatibility complex class I (MHC-I)</a> molecules on cell surface. To design the ligand peptides, we used reported antigen peptides for each MHC-I molecule with high binding affinity. From the crystal structure of the peptide/MHC-I complexes, we determined a modifiable residue in the antigen peptides and replaced this residue with a lysine with an ε-amine group modified with functional molecules. The designed ligand peptides successfully bound to cells expressing the corresponding MHC-I molecules via exchange of peptides bound to the MHC-I. We demonstrated that the peptide ligands could be used to transport a protein or a liposome to cells expressing the corresponding MHC-I. The present strategy may be useful for targeted delivery to cells overexpressing MHC-I, which have been observed autoimmune diseases.</p>

scholarly journals Loss of CD8 and TCR binding to Class I MHC ligands following T cell activation

2005 ◽  
Vol 17 (12) ◽  
pp. 1607-1617 ◽  
Author(s):  
Charlly Kao ◽  
Mark A. Daniels ◽  
Stephen C. Jameson
Keyword(s):  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Class I ◽  
Class I Mhc ◽  
Mhc Ligands

scholarly journals Reciprocal Transfer of Class I MHC Allele Specificity between Activating Ly-49P and Ly-49W Receptors by Exchange of β4–β5 Loop Residues

2003 ◽  
Vol 171 (10) ◽  
pp. 5337-5344 ◽  
Author(s):  
Brian J. Ma ◽  
Elizabeth T. Silver ◽  
Bart Hazes ◽  
Kevin P. Kane
Keyword(s):  
Class I ◽  
Class I Mhc ◽  
Allele Specificity ◽  
Reciprocal Transfer

scholarly journals Circular dichroism determination of class I MHC-peptide equilibrium dissociation constants

1997 ◽  
Vol 6 (8) ◽  
pp. 1771-1773 ◽  
Author(s):  
Chantal S. Morgan ◽  
James M. Holton ◽  
Barry D. Olafson ◽  
Pamela J. Bjorkman ◽  
Stephen L. Mayo
Keyword(s):  
Circular Dichroism ◽  
Dissociation Constants ◽  
Class I ◽  
Class I Mhc ◽  
Equilibrium Dissociation Constants ◽  
Equilibrium Dissociation ◽  
Circular Dichroïsm

IDENTIFICATION OF A CLASS I MHC-ASSOCIATED PEPTIDE DERIVED FROM THE METH A SARCOMA AND RECOGNIZED BY CD8+ T CELLS

1993 ◽  
Vol 14 (4) ◽  
pp. 369
Author(s):  
A Frassanito ◽  
J I Mayordomo ◽  
W J Storkus ◽  
M T Lotze ◽  
R DeLeo ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Class I ◽  
Class I Mhc ◽  
Meth A Sarcoma

Extensive inflammatory cell infiltration in human skeletal muscle in response to an ultraendurance exercise bout in experienced athletes

2013 ◽  
Vol 114 (1) ◽  
pp. 66-72 ◽  
Author(s):  
Peter Marklund ◽  
C. Mikael Mattsson ◽  
Britta Wåhlin-Larsson ◽  
Elodie Ponsot ◽  
Björn Lindvall ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Mhc Class I ◽  
Inflammatory Cell ◽  
Exercise Bout ◽  
Inflammatory Cell Infiltration ◽  
Class I ◽  
Cell Infiltration ◽  
Class I Mhc ◽  
Inflammatory Reactions ◽  
The Impact

The impact of a 24-h ultraendurance exercise bout on systemic and local muscle inflammatory reactions was investigated in nine experienced athletes. Blood and muscle biopsies were collected before (Pre), immediately after the exercise bout (Post), and after 28 h of recovery (Post28). Circulating blood levels of leukocytes, creatine kinase (CK), C-reactive protein (CRP), and selected inflammatory cytokines were assessed together with the evaluation of the occurrence of inflammatory cells (CD3+, CD8+, CD68+) and the expression of major histocompatibility complex class I (MHC class I) in skeletal muscle. An extensive inflammatory cell infiltration occurred in all athletes, and the number of CD3+, CD8+, and CD68+ cells were two- to threefold higher at Post28 compared with Pre ( P < 0.05). The inflammatory cell infiltration was associated with a significant increase in the expression of MHC class I in muscle fibers. There was a significant increase in blood leukocyte count, IL-6, IL-8, CRP, and CK at Post. At Post28, total leukocytes, IL-6, and CK had declined, whereas IL-8 and CRP continued to increase. Increases in IL-1β and TNF-α were not significant. There were no significant associations between the magnitude of the systemic and local muscle inflammatory reactions. Signs of muscle degenerative and regenerative events were observed in all athletes with various degrees of severity and were not affected by the 24-h ultraendurance exercise bout. In conclusion, a low-intensity but very prolonged single-endurance exercise bout can generate a strong inflammatory cell infiltration in skeletal muscle of well-trained experienced ultraendurance athletes, and the amplitude of the local reaction is not proportional to the systemic inflammatory response.

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