Antibody-mediated targeting of human single-chain class I MHC with covalently linked peptides induces efficient killing of tumor cells by tumor or viral-specific cytotoxic T lymphocytes

2005 ◽  
Vol 54 (9) ◽  
pp. 867-879 ◽  
Author(s):  
Kfir Oved ◽  
Avital Lev ◽  
Roy Noy ◽  
Dina Segal ◽  
Yoram Reiter
Keyword(s):  
T Lymphocytes ◽  
Tumor Cells ◽  
Cytotoxic T Lymphocytes ◽  
Class I ◽  
Single Chain ◽  
Class I Mhc ◽  
Covalently Linked

scholarly journals Expression of a single-chain HLA class I molecule in a human cell line: presentation of exogenous peptide and processed antigen to cytotoxic T lymphocytes.

1996 ◽  
Vol 93 (1) ◽  
pp. 236-240 ◽  
Author(s):  
K. Toshitani ◽  
V. Braud ◽  
M. J. Browning ◽  
N. Murray ◽  
A. J. McMichael ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cell Line ◽  
Cytotoxic T Lymphocytes ◽  
Human Cell ◽  
Hla Class I ◽  
Human Cell Line ◽  
Class I ◽  
Single Chain

In Vitro Induction of Specific Cytotoxic T Lymphocytes Using Recombinant Single-Chain MHC Class I/Peptide Complexes

1998 ◽  
Vol 21 (4) ◽  
pp. 283-294 ◽  
Author(s):  
Yu-Chun Lone ◽  
Iris Motta ◽  
Estelle Mottez ◽  
Yannik Guilloux ◽  
Annick Lim ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Mhc Class I ◽  
Cytotoxic T Lymphocytes ◽  
Class I ◽  
Single Chain ◽  
Peptide Complexes ◽  
In Vitro Induction

scholarly journals Use of synthetic peptides of influenza nucleoprotein to define epitopes recognized by class I-restricted cytotoxic T lymphocytes.

1987 ◽  
Vol 165 (6) ◽  
pp. 1508-1523 ◽  
Author(s):  
J Bastin ◽  
J Rothbard ◽  
J Davey ◽  
I Jones ◽  
A Townsend
Keyword(s):  
T Cells ◽  
T Lymphocytes ◽  
Infected Cell ◽  
Cytotoxic T Lymphocytes ◽  
Synthetic Peptides ◽  
Class Ii ◽  
Cytotoxicity Assay ◽  
Class I ◽  
Class I Mhc

The conserved epitopes of influenza nucleoprotein (NP) recognized by class I MHC-restricted CTL from CBA (H-2k) and C57BL/10 (H-2b) mice have been defined in vitro with synthetic peptides 50-63 and 365-379, respectively. Two Db-restricted clones were described that recognize different epitopes on peptide 365-379. Finally, the recognition of complete NP was shown to be approximately 200-fold less efficient than peptide in the cytotoxicity assay. These phenomena are closely related to results with class II-restricted T cells and they strengthen the hypothesis that influenza proteins are degraded in the infected cell before recognition by class I-restricted CTL.

Role of conserved regions of class I MHC molecules in the activation of CD8+ cytotoxic T lymphocytes by peptide and purified cell-free class I molecules

1993 ◽  
Vol 5 (9) ◽  
pp. 1129-1138 ◽  
Author(s):  
Toshiyuki Takeshita ◽  
Steven Kozlowski ◽  
Richard D. England ◽  
Richard Brower ◽  
Jonathan Schneck ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Class I ◽  
Class I Mhc ◽  
Mhc Molecules ◽  
Conserved Regions

Accessory Cell Requirements for Saponin Adjuvant-Induced Class I MHC Antigen-Restricted Cytotoxic T-Lymphocytes

1994 ◽  
Vol 154 (2) ◽  
pp. 393-406 ◽  
Author(s):  
Jia-Yan Wu ◽  
Bonnie H. Gardner ◽  
Nicholas N. Kushner ◽  
Lu-Ann M. Pozzi ◽  
Charlotte R. Kensil ◽  
...  
Keyword(s):  
T Lymphocytes ◽  
Cytotoxic T Lymphocytes ◽  
Class I ◽  
Accessory Cell ◽  
Class I Mhc ◽  
Mhc Antigen
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