scholarly journals Monoclonal Pathogenic Antibodies to the Thyroid-Stimulating Hormone Receptor in Graves’ Disease with Potent Thyroid-Stimulating Activity but Differential Blocking Activity Activate Multiple Signaling Pathways

2006 ◽  
Vol 176 (8) ◽  
pp. 5084-5092 ◽  
Author(s):  
Jacqueline A. Gilbert ◽  
Andrew G. Gianoukakis ◽  
Siamak Salehi ◽  
Jane Moorhead ◽  
Prakash V. Rao ◽  
...  
Keyword(s):  
Signaling Pathways ◽  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Blocking Activity ◽  
Pathogenic Antibodies ◽  
Multiple Signaling ◽  
Differential Blocking ◽  
Stimulating Hormone

scholarly journals Hipotiroidismo Associado a Anticorpos Anti-Receptor da Hormona TSH com Ação Bloqueadora Determinada In Vitro

2015 ◽  
Vol 28 (5) ◽  
pp. 663
Author(s):  
Pedro Marques ◽  
Karim Chikh ◽  
Anne Charrié ◽  
Rosa Pina ◽  
Maria João Bugalho ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Chinese Hamster Ovary Cells ◽  
Chinese Hamster ◽  
Thyroid Stimulating Hormone ◽  
Human Thyroid ◽  
In Vitro Tests ◽  
Lymphocytic Thyroiditis ◽  
Blocking Activity ◽  
Stimulating Hormone

Thyroid-stimulating hormone-receptor autoantibodies normally causes hyperthyroidism. However, they might have blocking activity causing hypothyroidism. A 11-year-old girl followed due to type 1 diabetes mellitus, celiac disease and euthyroid lymphocytic thyroiditis at diagnosis. Two years after the initial evaluation, thyroid-stimulating hormone was suppressed with normal free T4; nine months later, a biochemical evolution to hypothyroidism with thyroid-stimulating hormone-receptor autoantibodies elevation was seen; the patient remained always asymptomatic. Chinese hamster ovary cells were transfected with the recombinant human thyroid-stimulating hormone -receptor, and then exposed to the patient´s serum; it was estimated a ‘moderate’ blocking activity of these thyroid-stimulating hormone-receptor autoantibodies, and concomitantly excluded stimulating action. In this case, the acknowledgment of the blocking activity of the serum thyroid-stimulating hormone-receptor autoantibodies, supported the hypothesis of a multifactorial aetiology of the hypothyroidism, which in the absence of the in vitro tests, we would consider only as a consequence of the destructive process associated to lymphocytic thyroiditis.

Correlation of circulating miRNA-146a-5p and let-7b expression with thyroid-stimulating hormone receptor antibody in patients with graves disease

Gene Reports ◽  
2020 ◽  
Vol 19 ◽  
pp. 100608 ◽  
Author(s):  
Rashad Ayad Al-Heety ◽  
Hayfaa S. Al-Hadithi ◽  
Kismat M. Turki
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Circulating Mirna ◽  
Receptor Antibody ◽  
Stimulating Hormone

Similar Clinical Performance of a Novel Chimeric Thyroid-Stimulating Hormone Receptor Bioassay and an Automated Thyroid-Stimulating Hormone Receptor Binding Assay in Graves' Disease

Thyroid ◽  
2011 ◽  
Vol 21 (12) ◽  
pp. 1295-1299 ◽  
Author(s):  
Keiichi Kamijo ◽  
Hiroshi Murayama ◽  
Takahiro Uzu ◽  
Kazuyoshi Togashi ◽  
Paul D. Olivo ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Hormone Receptor ◽  
Binding Assay ◽  
Clinical Performance ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Receptor Binding Assay ◽  
Stimulating Hormone

Lack of effect of thyroxine administration on elevated thyroid stimulating hormone receptor antibody levels in treated Graves' disease patients.

1995 ◽  
Vol 80 (5) ◽  
pp. 1481-1484 ◽  
Author(s):  
H Tamai ◽  
I Hayaki ◽  
K Kawai ◽  
G Komaki ◽  
S Matsubayashi ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Receptor Antibody ◽  
Antibody Levels ◽  
Stimulating Hormone

scholarly journals Non-immune thyrotoxicosis caused by thyroid-stimulating hormone receptor activating gene mutation (the first description in Russia)

2009 ◽  
Vol 55 (2) ◽  
pp. 48-50
Author(s):  
V A Peterkova ◽  
O V Vasyukova ◽  
A N Tyul'pakov
Keyword(s):  
Pregnant Women ◽  
Gene Mutation ◽  
Clinical Picture ◽  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Maternal Antibodies ◽  
Graves Disease ◽  
Gene Encoding ◽  
Activating Mutations ◽  
Stimulating Hormone

Thyrotoxicosis of newborns, observed in less than 1% of pregnant women with Graves disease, is due to transplacental transfer of stimulating antibodies to the thyroid stimulating hormone receptor (rTSH). The clinical picture manifests itself in the first days of a child’s life, is transient in nature and, as a rule, ends with a full recovery as the maternal antibodies to rTSH disappear from the bloodstream of the newborn. However, in addition to the "classic" autoimmune thyrotoxicosis, cases of congenital and familial non-autoimmune thyrotoxicosis, which are caused by inherited activating mutations of the gene encoding rTSH - TSHR, have been described. This article presents its own observation.

Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes

2009 ◽  
Vol 108 (6) ◽  
pp. 551-556 ◽  
Author(s):  
Hidetaka Fukushima ◽  
Hideaki Matsuo ◽  
Koji Imamura ◽  
Kazuhiko Morino ◽  
Katsuzumi Okumura ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Hashimoto’S Disease ◽  
Hashimoto's Disease ◽  
Stimulating Hormone

scholarly journals Antibodies against thyroid‑stimulating hormone receptor cause maternal‑neonatal transmission of Graves' Disease

2021 ◽  
Vol 22 (5) ◽  
Author(s):  
Yue Yu ◽  
Qian-Qi Liu ◽  
De-Yun Liu ◽  
Dan-Dan Wang ◽  
Li-Qi Yang ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Stimulating Hormone
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