Diagnosis and discrimination of autoimmune Graves' disease and Hashimoto's disease using thyroid-stimulating hormone receptor-containing recombinant proteoliposomes

2009 ◽  
Vol 108 (6) ◽  
pp. 551-556 ◽  
Author(s):  
Hidetaka Fukushima ◽  
Hideaki Matsuo ◽  
Koji Imamura ◽  
Kazuhiko Morino ◽  
Katsuzumi Okumura ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Hashimoto’S Disease ◽  
Hashimoto's Disease ◽  
Stimulating Hormone

Correlation of circulating miRNA-146a-5p and let-7b expression with thyroid-stimulating hormone receptor antibody in patients with graves disease

Gene Reports ◽  
2020 ◽  
Vol 19 ◽  
pp. 100608 ◽  
Author(s):  
Rashad Ayad Al-Heety ◽  
Hayfaa S. Al-Hadithi ◽  
Kismat M. Turki
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Circulating Mirna ◽  
Receptor Antibody ◽  
Stimulating Hormone

Similar Clinical Performance of a Novel Chimeric Thyroid-Stimulating Hormone Receptor Bioassay and an Automated Thyroid-Stimulating Hormone Receptor Binding Assay in Graves' Disease

Thyroid ◽  
2011 ◽  
Vol 21 (12) ◽  
pp. 1295-1299 ◽  
Author(s):  
Keiichi Kamijo ◽  
Hiroshi Murayama ◽  
Takahiro Uzu ◽  
Kazuyoshi Togashi ◽  
Paul D. Olivo ◽  
...  
Keyword(s):  
Receptor Binding ◽  
Hormone Receptor ◽  
Binding Assay ◽  
Clinical Performance ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Receptor Binding Assay ◽  
Stimulating Hormone

Lack of effect of thyroxine administration on elevated thyroid stimulating hormone receptor antibody levels in treated Graves' disease patients.

1995 ◽  
Vol 80 (5) ◽  
pp. 1481-1484 ◽  
Author(s):  
H Tamai ◽  
I Hayaki ◽  
K Kawai ◽  
G Komaki ◽  
S Matsubayashi ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Receptor Antibody ◽  
Antibody Levels ◽  
Stimulating Hormone

scholarly journals Non-immune thyrotoxicosis caused by thyroid-stimulating hormone receptor activating gene mutation (the first description in Russia)

2009 ◽  
Vol 55 (2) ◽  
pp. 48-50
Author(s):  
V A Peterkova ◽  
O V Vasyukova ◽  
A N Tyul'pakov
Keyword(s):  
Pregnant Women ◽  
Gene Mutation ◽  
Clinical Picture ◽  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Maternal Antibodies ◽  
Graves Disease ◽  
Gene Encoding ◽  
Activating Mutations ◽  
Stimulating Hormone

Thyrotoxicosis of newborns, observed in less than 1% of pregnant women with Graves disease, is due to transplacental transfer of stimulating antibodies to the thyroid stimulating hormone receptor (rTSH). The clinical picture manifests itself in the first days of a child’s life, is transient in nature and, as a rule, ends with a full recovery as the maternal antibodies to rTSH disappear from the bloodstream of the newborn. However, in addition to the "classic" autoimmune thyrotoxicosis, cases of congenital and familial non-autoimmune thyrotoxicosis, which are caused by inherited activating mutations of the gene encoding rTSH - TSHR, have been described. This article presents its own observation.

scholarly journals Antibodies against thyroid‑stimulating hormone receptor cause maternal‑neonatal transmission of Graves' Disease

2021 ◽  
Vol 22 (5) ◽  
Author(s):  
Yue Yu ◽  
Qian-Qi Liu ◽  
De-Yun Liu ◽  
Dan-Dan Wang ◽  
Li-Qi Yang ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Stimulating Hormone

scholarly journals The development of Graves' disease after long-term hypothyroidism due to Hashimoto's disease

2020 ◽  
Vol 66 (5) ◽  
pp. 24-30
Author(s):  
E. A. Panfilova ◽  
L. P. Kruk ◽  
M. P. Isaeva ◽  
P. O. Osmanova ◽  
F. A. Bostanova ◽  
...  
Keyword(s):  
Hormone Receptor ◽  
Clinical Case ◽  
Thyroid Volume ◽  
Thyroid Stimulating Hormone ◽  
Graves Disease ◽  
Autoimmune Thyroid Diseases ◽  
Autoimmune Thyroid ◽  
Blocking Antibodies ◽  
Stimulating Hormone

The main autoimmune thyroid diseases are Hashimoto's thyroiditis (HT) and Graves' disease (GD). Despite the significant differences in a pathogenesis and a clinical picture between HT and GD, the literature describes the cases of the conversion of one autoimmune disease to another, which, according to one version, is associated with a change in the balance between the levels of a stimulating and blocking antibodies to the thyroid-stimulating hormone receptor. At the same time, there are more frequent observations of the transition of GD to HT, and much less often describe, on the contrary, the development of GD against the background of HT. The article presents a clinical case of the conversion of HT to GD. A detailed algorithm of the conservative management according to the «block-replace» scheme is described, indicating the results of laboratory and instrumental examination. At the time of describing the clinical case, the result of the treatment can be considered successful. The predictors such as a low level of the thyroid-stimulating hormone receptor and thyroid volume before discontinuation of the thyrostatic therapy suggest a low risk of the recrudescence of GD.According to the authors, the phenomenon of the conversion of one autoimmune thyroid disease to another, in addition to the scientific interest, is important for the practitioners, since a timely change in the diagnostic paradigm can significantly change the treatment strategy and the favorably affect the prognosis of disease, preventing the development of complications.

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