scholarly journals Aire Controls Heterogeneity of Medullary Thymic Epithelial Cells for the Expression of Self-Antigens

2021 ◽  
pp. ji2100692
Author(s):  
Hitoshi Nishijima ◽  
Minoru Matsumoto ◽  
Junko Morimoto ◽  
Kazuyoshi Hosomichi ◽  
Nobuko Akiyama ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Self Antigens

scholarly journals Contrasting models of promiscuous gene expression by thymic epithelium

2005 ◽  
Vol 202 (1) ◽  
pp. 15-19 ◽  
Author(s):  
Geoffrey O. Gillard ◽  
Andrew G. Farr
Keyword(s):  
Gene Expression ◽  
Epithelial Cells ◽  
Broad Spectrum ◽  
Alternative Model ◽  
Thymic Epithelial Cells ◽  
Central Tolerance ◽  
Thymic Epithelium ◽  
Medullary Thymic Epithelial Cells ◽  
Promiscuous Gene Expression ◽  
Self Antigens

Medullary thymic epithelial cells (mTECs) express a broad spectrum of tissue- restricted self-antigens (TRAs), which are required for the development of central tolerance. A new study suggests that TRA expression is a specialized property of terminally differentiated mTECs. However, as discussed here, an alternative model—whereby TRA expression is regulated by conserved developmental programs active in developing mTECs—may be equally plausible.

scholarly journals Lymphotoxin β Receptor Regulates the Development of CCL21-Expressing Subset of Postnatal Medullary Thymic Epithelial Cells

2013 ◽  
Vol 190 (10) ◽  
pp. 5110-5117 ◽  
Author(s):  
Enkhsaikhan Lkhagvasuren ◽  
Mie Sakata ◽  
Izumi Ohigashi ◽  
Yousuke Takahama
Keyword(s):  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells ◽  
Β Receptor

scholarly journals Foxn1 Regulates Lineage Progression in Cortical and Medullary Thymic Epithelial Cells But Is Dispensable for Medullary Sublineage Divergence

PLoS Genetics ◽  
2011 ◽  
Vol 7 (11) ◽  
pp. e1002348 ◽  
Author(s):  
Craig S. Nowell ◽  
Nicholas Bredenkamp ◽  
Stéphanie Tetélin ◽  
Xin Jin ◽  
Christin Tischner ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells

scholarly journals Diversity in medullary thymic epithelial cells controls the activity and availability of iNKT cells

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Beth Lucas ◽  
Andrea J. White ◽  
Emilie J. Cosway ◽  
Sonia M. Parnell ◽  
Kieran D. James ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Inkt Cells ◽  
Medullary Thymic Epithelial Cells

Ultrastructure of medullary thymic epithelial cells of autoimmune regulator (Aire)‐deficient mice

2009 ◽  
Vol 88 (1) ◽  
pp. 50-56 ◽  
Author(s):  
Živana Milićević ◽  
Novica M Milićević ◽  
Martti Laan ◽  
Pärt Peterson ◽  
Kai Kisand ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Autoimmune Regulator ◽  
Medullary Thymic Epithelial Cells ◽  
Deficient Mice

scholarly journals NF-κB2 Is Required for the Control of Autoimmunity by Regulating the Development of Medullary Thymic Epithelial Cells

2006 ◽  
Vol 281 (50) ◽  
pp. 38617-38624 ◽  
Author(s):  
Baochun Zhang ◽  
Zhe Wang ◽  
Jane Ding ◽  
Pärt Peterson ◽  
William T. Gunning ◽  
...  
Keyword(s):  
Epithelial Cells ◽  
Thymic Epithelial Cells ◽  
Medullary Thymic Epithelial Cells
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