An Observation in Coronary Collateral Circulation and Left Ventricular Function

Abstract Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.

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Coronary collateral vessels: Spectrum of physiologic capabilities with respect to providing rest and stress myocardial perfusion, maintenance of left ventricular function and protection against infarction

The American Journal of Cardiology ◽

10.1016/0002-9149(82)90171-0 ◽

1982 ◽

Vol 50 (2) ◽

pp. 230-238 ◽

Cited By ~ 70

Author(s):

Albert J. Kolibash ◽

Charles A. Bush ◽

Richard A. Wepsic ◽

David P. Schroeder ◽

Marc R. Tetalman ◽

...

Keyword(s):

Myocardial Perfusion ◽

Left Ventricular Function ◽

Ventricular Function ◽

Left Ventricular ◽

Stress Myocardial Perfusion ◽

Coronary Collateral ◽

Collateral Vessels

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Reciprocal relationship between left ventricular filling pressure and the recruitable human coronary collateral circulation

European Heart Journal ◽

10.1093/eurheartj/ehi051 ◽

2004 ◽

Vol 26 (6) ◽

pp. 558-566 ◽

Cited By ~ 19

Author(s):

Stefano F. de Marchi ◽

Philipp Oswald ◽

Stephan Windecker ◽

Bernhard Meier ◽

Christian Seiler

Keyword(s):

Collateral Circulation ◽

Left Ventricular ◽

Filling Pressure ◽

Reciprocal Relationship ◽

Left Ventricular Filling ◽

Left Ventricular Filling Pressure ◽

Coronary Collateral Circulation ◽

Coronary Collateral ◽

Ventricular Filling Pressure ◽

Ventricular Filling

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Collateral Circulation in Human Heart

Bosnian Journal of Basic Medical Sciences ◽

10.17305/bjbms.2005.3295 ◽

2008 ◽

Vol 5 (2) ◽

pp. 87-91

Author(s):

Aida Hasanović ◽

Fuad Šišić ◽

Faruk Dilberović ◽

Fehim Ovčina

Keyword(s):

Coronary Artery ◽

Coronary Angiography ◽

Left Ventricular Function ◽

Ventricular Function ◽

Coronary Arteries ◽

Collateral Circulation ◽

Left Ventricular ◽

Cardiology Department ◽

Different Types ◽

The Right

The aim of the investigations was to demonstrate different types of collaterals of coronary arteries using the method of coronary angiography and injection-corrosion method. The investigations were carried out on 30 human cadaveric hearts from the Department of Anatomy, and 30 angiograms of patients from the Cardiology Department of Clinics Centre in Sarajevo. Clinical investigations were retrospective and prospective on patients that were treated in hospital, and on patients that just arrived in hospital (based on findings of coronary angiohra-phy). The results show the existence of different types of collaterals: intercoronary and intra-coronary. We established collaterals in a case with occlusion of the right coronary artery and left coronary artery in which better development of collaterals was established. Our patients were classified in two groups:1) Patients with good collaterals and good left ventricular function;2) Patients with good collaterals and impaired left ventricular function. On the anatomical material we found different types of collaterals as well.Our results show that coronanary angiography is useful diagnostic method for the demonstration of coronary collaterals.The collaterals of human coronary arteries have always attracted the attention of anatomists, pathologists, surgeons, as well as experts in many clinical disciplines. The occurrence of coronary diseases has increased recently so much that it stimulates researchers to become acquainted with collaterals of coronary arteries. Its real significance is expressive in cases with occlusion or stenosis of coronary arteries -angina, myocardial infarction, congenital cardiovascular malformations etc. (1,2,3,4,5). Therefore, the aim of the investigations was to demonstrate different types of collaterals of the coronary arteries in normal condition and the conditions of coronary disease using the method of coronary angiography and injection corrosion method. On the other side, these investigations are important because of contrast opinions that are given in literature concerning coronary arteries collaterals. According to some authors collaterals exist and they are functional (6,7,8,9,10). The others think that collaterals exist, but that they are insufficient for collateral circulation and only develop in pathological conditions (11). Ishemia changes of the heart, variations of coronary arteries and the collaterals have been studied by many authors: Hadžiselimović, Werner, Pohl, Seiler, Kamenica, Šišić, Rockostroh, Rapps, Holmvang, Billinger, Meier and others.

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The preservation effect of coronary collateral circulation on left ventricular function in chronic total occlusion and its association with the expression of vascular endothelial growth factor A

Advances in Clinical and Experimental Medicine ◽

10.17219/acem/104535 ◽

2020 ◽

Vol 29 (4) ◽

pp. 493-497

Author(s):

Yuxiang Dai ◽

Shufu Chang ◽

Shen Wang ◽

Yi Shen ◽

Chenguang Li ◽

...

Keyword(s):

Vascular Endothelial Growth Factor ◽

Growth Factor ◽

Left Ventricular Function ◽

Collateral Circulation ◽

Chronic Total Occlusion ◽

Left Ventricular ◽

Vascular Endothelial ◽

Total Occlusion ◽

Coronary Collateral Circulation ◽

Endothelial Growth Factor

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Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation

10.21203/rs.2.12560/v2 ◽

2019 ◽

Author(s):

Xin Chen ◽

Yan Lin ◽

Lihua Tian ◽

Zhiquan Wang

Keyword(s):

Roc Curve ◽

Collateral Circulation ◽

Total Bilirubin ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Coronary Collateral Circulation ◽

Ventricular Ejection Fraction ◽

Coronary Collateral ◽

The Poor ◽

Good Group

Abstract Abstract Objective: To investigate the correlation between ischaemia modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease(CTO).Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery.According to the Rentrop evaluation criteria,the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade,n=69)and CCC formation good group(Rentrop2-3grade,n=59).The IMA level of the patients was measured using an albumin-cobalt binding assay.Record and analyze the patient's general data, blood routine,total bilirubin(TBIL),blood lipids,uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators,while recording the patient's occlusion of blood vessels.Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation[OR=1.190,95%CI(1.092-1.297),P<0.001],diabetes was negatively correlated with CCC formation[OR=0.285,95%CI(0.094-0.864),P<0.05].Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769(95%CI:0.686-0.851，P＜0.001);the optimal cut-off value was 63.35KU/L,the sensitivity is 71.2%,specificity is 71%.Conclusion: The IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.

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