CAEC (COMMUNITY OF ACTIVE ENGLISH COMMUNICATION)-BASED EMPOWERMENT OF LAKE TEMPE WAJO TOURISM REGIONAL COMMUNITIES

South Sulawesi's Lake Tempe is a popular tourist site. Many foreigners, both locally and internationally, visit Lake Tempe. The quality of the guide's service has a significant impact on the smoothness and comfort of travel in Tempe. As a result, a training and mentoring program for foreign-language tourism performers in the Tempe Lake area is required. The PKM program is carried out in stages: (1) PKM participant selection; (2) PKM briefing participants; (3) survey site; (4) PKM program socialization; (5) debriefing tourist actors; and (6) twice-weekly training and mentorship for three months. In total, 25 meetings were held to provide training and mentorship. The training team enhances the vocabulary at the start of the training, and subsequently, the material and speaking are intensified by the team. The assessment's findings revealed a significant increase: (1) There were three people in the very good group, 25 in the good category, and two in the bad category when it came to vocabulary ability. (2) There are 26 persons who are classified as good at tenses, and just four people who are classified as less good. (3) In terms of speaking skill, four people were rated as very good, 25 were rated as good, and one was rated as less good.

Predictive Value of Albumin and Neutrophil Combined Prognostic Grade in Advanced Gastric Cancer Patients Treated With anti-PD-1 Therapy

Background The application of immunotherapy is gradually increasing in advanced gastric cancer (AGC), but only some patients could benefit from it. Validated biomarkers can screen out the beneficiaries. The objective of this research is to explore the predictive value of albumin and neutrophil combined prognostic grade ( ANPG) in AGC patients receiving immunotherapy. Methods A total number of 268 AGC patients were included. The cut-off value of albumin was 38 g/L obtained by the median value, and neutrophil was 4.16 g/L estimated by the average value. The high levels of albumin (≥38 g/L) and neutrophil (≥4.16 g/L) were considered to be two risk factors for ANPG. Based on these two risk factors, patients were categorized into 3 groups：the risk factor number for the "good" group was 0, for the "intermediate" group was 1, and for the "poor" group was 2. Results Patients with the good ANPG was related to longer progression free survival (PFS) and overall survival (OS), compared to those with the intermediate and the poor ANPG (5.6 months vs 5.3 months vs 3.4 months, 17.8 months vs 11.8 months vs 8.2 months). The poor group was independently correlated with an over 1.9 times risk of disease progression (HR=1.901; 95% CI, 1.314-2.750; P=0.001) and an over 2 times risk of death (HR=2.003; 95% CI, 1.306-3.072; P=0.001) than the good group. The intermediate group was independently correlated with an over 1.3 times risk of disease progression (HR=1.385; 95% CI, 1.004-1.911; P=0.048) and an over 1.4 times risk of death (HR=1.484; 95% CI, 1.046-2.106; P=0.027) than the good group. Conclusion Our study verifies, for the first time, that ANPG is an independent factor affecting survival of AGC patients receiving immunotherapy. Patients with the good ANPG could benefit from immunotherapy.

Gropes, Towers, and Skyscrapers

Gropes, towers, and skyscrapers are carefully defined. These are the objects that the rest of Part II studies and seeks to construct. All three are 4-manifolds with boundary, obtained from stacking thickened surfaces on top of one another. Gropes are constructed from thickened orientable surfaces with positive genus, each stage attached to a symplectic basis of curves for the homology of the previous stage. Towers have an additional type of stage obtained from plumbed thickened discs. A skyscraper is the endpoint compactification of an infinite tower. An introduction to endpoint compactifications is included. The notion of a good group is also defined.

Chemoselective catalytic hydrodefluorination of trifluoromethylalkenes towards mono-/gem-di-fluoroalkenes under metal-free conditions

Fluorine-containing moieties show significant effects in improving the properties of functional molecules. Consequently, efficient methods for installing them into target compounds are in great demand, especially those enabled by metal-free catalysis. Here we show a diazaphospholene-catalyzed hydrodefluorination of trifluoromethylalkenes to chemoselectively construct gem-difluoroalkenes and terminal monofluoroalkenes by simple adjustment of the reactant stoichiometry. This metal-free hydrodefluorination features mild reaction conditions, good group compatibility, and almost quantitative yields for both product types. Stoichiometric experiments indicated a stepwise mechanism: hydridic addition to fluoroalkenes and subsequent β-F elimination from hydrophosphination intermediates. Density functional theory calculations disclosed the origin of chemoselectivity, regioselectivity and stereoselectivity, suggesting an electron-donating effect of the alkene-terminal fluorine atom.

A New “Good and Bad Groups-Based Optimizer” for Solving Various Optimization Problems

Optimization is the science that presents a solution among the available solutions considering an optimization problem’s limitations. Optimization algorithms have been introduced as efficient tools for solving optimization problems. These algorithms are designed based on various natural phenomena, behavior, the lifestyle of living beings, physical laws, rules of games, etc. In this paper, a new optimization algorithm called the good and bad groups-based optimizer (GBGBO) is introduced to solve various optimization problems. In GBGBO, population members update under the influence of two groups named the good group and the bad group. The good group consists of a certain number of the population members with better fitness function than other members and the bad group consists of a number of the population members with worse fitness function than other members of the population. GBGBO is mathematically modeled and its performance in solving optimization problems was tested on a set of twenty-three different objective functions. In addition, for further analysis, the results obtained from the proposed algorithm were compared with eight optimization algorithms: genetic algorithm (GA), particle swarm optimization (PSO), gravitational search algorithm (GSA), teaching–learning-based optimization (TLBO), gray wolf optimizer (GWO), and the whale optimization algorithm (WOA), tunicate swarm algorithm (TSA), and marine predators algorithm (MPA). The results show that the proposed GBGBO algorithm has a good ability to solve various optimization problems and is more competitive than other similar algorithms.

Yb(OTf)3-mediated regioselective hydroamination of ynamides with anilines or p-toluenesulfonamide

A rare-earth salts Yb(OTf)3-catalyzed regioselective hydroamination of ynamides with anilines or p-toluenesulfonamide has been developed. This protocol provided facile access to a diverse range of amidines with good group functional group tolerance in moderate to high yield.

Analisis Logika, Riset, Kebenaran Dalam Pendidikan di Indonesia

The digital era provides its own meaning and consequences for the morale of the leadership group. This study aims to analyze the morals of Islamic leadership groups in the digital era based on a review of philosophy, psychology and sociology. A leader in the digital era is required to be compatible with the demands and needs of the times. Philosophically, the morale of the leadership group provides reinforcement in decision making or policy formulation. Psychologically, group morals give its own color to aspects of personality. Leaders must be able to influence their members so that they can jointly run the organization. Sociologically, the moral of the leadership group has similarities with the religious foundation. Everyone is required to be able to have and practice good group morals in various conditions. This kind of leadership is expected by many people. The challenge of social education leaders today is very hard to be able to provide awareness to students and educationists to be able to socialize and get used to completely online work.

Moderating Effects of Organizational Climate on the Relationship between Emotional Labor and Burnout among Korean Firefighters

This study examined the association of emotional labor and organizational climate with burnout and elucidated the moderating effect of organizational climate on the relationship between emotional labor and burnout among 18,936 Korean firefighters (male: 17,790, 93.9%, female: 1146, 6.1%). To examine the effects of organizational climate on the relationships between five sub-scales of emotional labor and burnout, four groups were created using various combinations of emotional labor (“normal” vs. “risk”) and organizational climate (“good” vs. “bad”): (1) “normal” and “good” (Group I), (2) “normal” and “bad” (Group II), (3) “risk” and “good” (Group III), and (4) “risk” and “bad” (Group IV). A hierarchical multiple linear regression analysis indicated that firefighters’ burnout was significantly higher in the group with “bad” than “good” organizational climate and was significantly higher among people with “risk” than “normal” emotional labor. Combined effects of organizational climate with emotional labor on burnout were observed in all five sub-scales. Groups II, III, and IV were more likely to experience burnout than Group I (trend p < 0.001). Additionally, the moderating effects of organizational climate on the relationship between the five sub-scales of emotional labor and burnout were observed, except for factor 5. These results emphasize the importance of stress management to alleviate burnout caused by emotional labor at the organizational level and coping strategies to reinforce the personal potentiality suitable to organizational norms at the individual level.

How important is distractor efficiency for grading Best Answer Questions?

Background Distractor efficiency and the optimum number of functional distractors per item in One Best Answer Questions have been debated. The prevalence of non-functional distractors has led to a reduction in the number of distractors per item with the advantage of adding more items in the test. The existing literature eludes a definite answer to the question of what distractor efficiency best matches excellent psychometric indices. We examined the relationship between distractor efficiency and the psychometric indices of One Best Answer Questions in search of an answer. Methods We analysed 350 items used in 7 professional examinations and determined their distractor efficiency and the number of functional distractors per item. The items were sorted into five groups - excellent, good, fair, remediable and discarded based on their discrimination index. We studied how the distractor efficiency and functional distractors per item correlated with these five groups. Results Correlation of distractor efficiency with psychometric indices was significant but far from perfect. The excellent group topped in distractor efficiency in 3 tests, the good group in one test, the remediable group equalled excellent group in one test, and the discarded group topped in 2 tests. Conclusions The distractor efficiency did not correlate in a consistent pattern with the discrimination index. Fifty per cent or higher distractor efficiency, not hundred percent, was found to be the optimum.

Association of the Metabolic Score Using Baseline FDG-PET/CT and dNLR with Immunotherapy Outcomes in Advanced NSCLC Patients Treated with First-Line Pembrolizumab

Background: We aimed to assess the clinical utility of a previously published score combining the total metabolic tumor volume (TMTV) on baseline FDG-PET/CT and pretreatment derived from the neutrophils to lymphocytes ratio (dNLR) for prognostication in NSCLC patients undergoing first-line immunotherapy (IT). Methods: In this multicenter retrospective study, 63 advanced NSCLC patients with a PD-L1 tumor proportion score (TPS) ≥50%, who underwent FDG-PET/CT before first-line IT, treated from January 2017 to September 2019, were enrolled. Associations between this score and the progression-free survival (PFS), overall survival (OS), disease control rate (DCR), and overall response rate (ORR) were evaluated. Results: The median (m) PFS and mOS were 7.7 (95% CI 4.9–10.6) and 12.1 (8.6–15.6) months, respectively, and DCR and ORR were 65% and 58%, respectively. mOS was 17.9 months (14.6 not reached) for the good group versus 13.8 (95%CI 8.4–18.9) and 6.6 (CI 2.0–11.2) months for the intermediate and poor groups, respectively. mPFS was 15.1 (95%CI 12.1–20.0) months for the good group versus 5.2 (1.9–8.5) and 1.9 (95%CI 1.3–2.5) months for the intermediate and poor groups, respectively. The poor prognosis group was associated with DCR and ORR (p < 0.05). Conclusions: The metabolic score combining TMTV on the baseline FDG-PET/CT scan and pretreatment dNLR was associated with the survival and response in a cohort of advanced NSCLC patients with ≥50% PD-L1 receiving frontline IT.