Statin promotes coronary collateral circulation and induces the regression of left ventricular mass in patients with angina

Abstract Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.

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Significance of arterial hypertension on coronary collateral circulation development and left ventricular function in coronary artery disease

Journal of Hypertension ◽

10.1097/00004872-198812040-00044 ◽

1988 ◽

Vol 6 (4) ◽

pp. S151-153 ◽

Cited By ~ 9

Author(s):

Eva A. Karpanou ◽

Gregory P. Vyssoulis ◽

John N. Skoumas ◽

George A. Zervopoulos ◽

Vaso S. Moundaki ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Arterial Hypertension ◽

Left Ventricular Function ◽

Ventricular Function ◽

Collateral Circulation ◽

Left Ventricular ◽

Coronary Collateral Circulation ◽

Coronary Collateral ◽

Artery Disease

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Reciprocal relationship between left ventricular filling pressure and the recruitable human coronary collateral circulation

European Heart Journal ◽

10.1093/eurheartj/ehi051 ◽

2004 ◽

Vol 26 (6) ◽

pp. 558-566 ◽

Cited By ~ 19

Author(s):

Stefano F. de Marchi ◽

Philipp Oswald ◽

Stephan Windecker ◽

Bernhard Meier ◽

Christian Seiler

Keyword(s):

Collateral Circulation ◽

Left Ventricular ◽

Filling Pressure ◽

Reciprocal Relationship ◽

Left Ventricular Filling ◽

Left Ventricular Filling Pressure ◽

Coronary Collateral Circulation ◽

Coronary Collateral ◽

Ventricular Filling Pressure ◽

Ventricular Filling

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Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation

10.21203/rs.2.12560/v2 ◽

2019 ◽

Author(s):

Xin Chen ◽

Yan Lin ◽

Lihua Tian ◽

Zhiquan Wang

Keyword(s):

Roc Curve ◽

Collateral Circulation ◽

Total Bilirubin ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Coronary Collateral Circulation ◽

Ventricular Ejection Fraction ◽

Coronary Collateral ◽

The Poor ◽

Good Group

Abstract Abstract Objective: To investigate the correlation between ischaemia modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease(CTO).Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery.According to the Rentrop evaluation criteria,the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade,n=69)and CCC formation good group(Rentrop2-3grade,n=59).The IMA level of the patients was measured using an albumin-cobalt binding assay.Record and analyze the patient's general data, blood routine,total bilirubin(TBIL),blood lipids,uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators,while recording the patient's occlusion of blood vessels.Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation[OR=1.190,95%CI(1.092-1.297),P<0.001],diabetes was negatively correlated with CCC formation[OR=0.285,95%CI(0.094-0.864),P<0.05].Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769(95%CI:0.686-0.851，P＜0.001);the optimal cut-off value was 63.35KU/L,the sensitivity is 71.2%,specificity is 71%.Conclusion: The IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.

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Effect of physical training on coronary collateral circulation of the rat

Journal of Applied Physiology ◽

10.1152/jappl.1982.52.2.376 ◽

1982 ◽

Vol 52 (2) ◽

pp. 376-387 ◽

Cited By ~ 10

Author(s):

J. E. Koerner ◽

R. L. Terjung

Keyword(s):

Blood Flow ◽

Physical Training ◽

Collateral Circulation ◽

Diastolic Pressure ◽

Left Ventricular ◽

Border Zone ◽

Coronary Collateral Circulation ◽

Coronary Collateral ◽

Border Zones ◽

Wide Range

The influence of physical training on coronary collateral circulation following acute ligation of the left coronary artery was determined in pentobarbital-anesthetized rats. Coronary blood flows were determined with 15-microns microspheres during a wide range of perfusion pressures and during adenosine infusion. The demarcation between normal and ischemic tissue was achieved using nitroblue tetrazolium strain and thioflavin S fluorescence. Contractile performance was not altered by training, with the exception of a lower left ventricular end-diastolic pressure when afterload was elevated. Blood flow to and the size of the central ischemic zone were not influenced by training. However, in border zones, where collateral dependent flow is expected to be most pronounced, blood flow as a percent of normal was increased (16%, P less than 0.02) in trained animals. This increased was abolished by coronary vasodilation with adenosine. These results indicate that training caused a limited increase in collateral blood flow to the border zone. Further, tissue reactivity to adenosine following short periods of ischemia is normal in trained rats but decreased in border (11%) and ischemic (21%, P less than 0.05) zones in sedentary rats. Whether his small increase in blood flow to the border tissue, along with a retained capacity for dilatation, could lead to an improved salvage of tissue remains to be evaluated.

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