Correlation Between Ischemia-Modified Albumin Level and Coronary Collateral Circulation

Abstract Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessel occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05]. Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.

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Correlation Between Ischemia-Modified Albumin Level And Coronary Collateral Circulation

10.21203/rs.2.12560/v3 ◽

2020 ◽

Author(s):

Xin Chen ◽

Yan Lin ◽

Lihua Tian ◽

Zhiquan Wang

Keyword(s):

Roc Curve ◽

Collateral Circulation ◽

Total Bilirubin ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Coronary Collateral Circulation ◽

Ventricular Ejection Fraction ◽

Ischemia Modified Albumin ◽

Coronary Collateral ◽

The Poor

Abstract Objective: To investigate the correlation between ischemia-modified albumin (IMA) levels and coronary collateral circulation (CCC) in patients with chronic total occlusive (CTO). Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to identify 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into the poor CCC formation group (Rentrop0-1 grade,n=69) and the good CCC formation group(Rentrop2-3 grade,n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay.The general data, routine blood panel, total bilirubin (TBIL), blood lipids, uric acid (UA), left ventricular ejection fraction (LVEF) and other indicators of the patients were recorded and analyzed while assessing the patients' blood vessels occlusion. Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good CCC group (P<0.05). The ratio of ischemia-modified albumin and total bilirubin in the poor CCC group was lower than that in the good CCC group (P<0.05). Multivariate logistic regression analysis showed that ischemia-modified albumin was positively correlated with CCC formation [OR=1.190,95% CI(1.092-1.297),P<0.001], while diabetes was negatively correlated with CCC formation [OR=0.285,95% CI(0.094-0.864),P<0.05].Ischemic modified albumin predicted good formation of CCC according to the ROC curve, and the area under the ROC curve was 0.769(95% CI:0.686-0.851，P＜0.001); the optimal cut-off value was 63.35 KU/L, and the sensitivity was 71.2%,specificity is 71%. Conclusion: The IMA level is closely related to good formation of CCC. Higher IMA levels can be used as an effective predictor of good CCC formation in patients with CTO.

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Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation

10.21203/rs.2.12560/v2 ◽

2019 ◽

Author(s):

Xin Chen ◽

Yan Lin ◽

Lihua Tian ◽

Zhiquan Wang

Keyword(s):

Roc Curve ◽

Collateral Circulation ◽

Total Bilirubin ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Coronary Collateral Circulation ◽

Ventricular Ejection Fraction ◽

Coronary Collateral ◽

The Poor ◽

Good Group

Abstract Abstract Objective: To investigate the correlation between ischaemia modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease(CTO).Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery.According to the Rentrop evaluation criteria,the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade,n=69)and CCC formation good group(Rentrop2-3grade,n=59).The IMA level of the patients was measured using an albumin-cobalt binding assay.Record and analyze the patient's general data, blood routine,total bilirubin(TBIL),blood lipids,uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators,while recording the patient's occlusion of blood vessels.Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation[OR=1.190,95%CI(1.092-1.297),P<0.001],diabetes was negatively correlated with CCC formation[OR=0.285,95%CI(0.094-0.864),P<0.05].Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769(95%CI:0.686-0.851，P＜0.001);the optimal cut-off value was 63.35KU/L,the sensitivity is 71.2%,specificity is 71%.Conclusion: The IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.

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Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation

10.21203/rs.2.12560/v1 ◽

2019 ◽

Author(s):

Xin Chen ◽

Yan Lin ◽

Lihua Tian ◽

Zhiquan Wang

Keyword(s):

Roc Curve ◽

Collateral Circulation ◽

Total Bilirubin ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Coronary Collateral Circulation ◽

Ventricular Ejection Fraction ◽

Coronary Collateral ◽

The Poor ◽

Good Group

Abstract ObjectiveTo investigate the correlation between ischemic modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease (CTO).MethodsCoronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery. According to the Rentrop evaluation criteria, the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade, n=69) and CCC formation good group (Rentrop2-3grade, n=59). The IMA level of the patients was measured using an albumin-cobalt binding assay. Record and analyze the patient's general data, blood routine, total bilirubin(TBIL), blood lipids, uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators, while recording the patient's occlusion of blood vessels.ResultsThe proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation(OR=1.190,95%CI (1.092-1.297),P<0.001), diabetes was negatively correlated with CCC formation (OR=0.285,95%CI(0.094-0.864),P<0.05). Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769 (95% CI 0.686-0.851, P<0.001); the optimal cut-off value was 63.35KU/L, the sensitivity is 71.2%,specificity is 71%.ConclusionThe IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.

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New Hybrid Method for Left Ventricular Ejection Fraction Assessment from Radionuclide Ventriculography Images

Current Medical Imaging Formerly Current Medical Imaging Reviews ◽

10.2174/1573405616666201118122509 ◽

2020 ◽

Vol 16 ◽

Author(s):

Halima Dziri ◽

Mohamed Ali Cherni ◽

Dorra Ben Sellem

Keyword(s):

Left Ventricular Ejection Fraction ◽

Left Ventricle ◽

Ejection Fraction ◽

Positive Predictive Value ◽

Roc Curve ◽

Radionuclide Ventriculography ◽

Left Ventricular ◽

The Other ◽

Left Ventricular Ejection ◽

Ventricular Ejection Fraction

Background: In this paper, we propose a new efficient method of radionuclide ventriculography image segmentation to estimate the left ventricular ejection fraction. This parameter is an important prognostic factor for diagnosing abnormal cardiac function. Methods: The proposed method combines the Chan-Vese and the mathematical morphology algorithms. It was applied to diastolic and systolic images obtained from the Nuclear Medicine Department of Salah AZAIEZ Institute.In order to validate our proposed method, we compare the obtained results to those of two methods of the literature. The first one is based on mathematical morphology, while the second one uses the basic Chan-Vese algorithm. To evaluate the quality of segmentation, we compute accuracy, positive predictive value and area under the ROC curve. We also compare the left ventricle ejection fraction estimated by our method to that of the reference given by the software of the gamma-camera and validated by the expert, using Pearson’s correlation coefficient, ANOVA test and linear regression. Results and conclusion: Static results show that the proposed method is very efficient in the detection of the left ventricle. The accuracy was 98.60%, higher than that of the other two methods (95.52% and 98.50%). Likewise, the positive predictive value was the highest (86.40% vs. 83.63% 71.82%). The area under the ROC curve was also the most important (0.998% vs. 0.926% 0.919%). On the other hand, Pearson's correlation coefficient was the highest (99% vs. 98% 37%). The correlation was significantly positive (p<0.001).

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The Use of Artificial Hypoxia in Endurance Training in Patients after Myocardial Infarction

International Journal of Environmental Research and Public Health ◽

10.3390/ijerph18041633 ◽

2021 ◽

Vol 18 (4) ◽

pp. 1633 ◽

Cited By ~ 1

Author(s):

Agata Nowak-Lis ◽

Tomasz Gabryś ◽

Zbigniew Nowak ◽

Paweł Jastrzębski ◽

Urszula Szmatlan-Gabryś ◽

...

Keyword(s):

Myocardial Infarction ◽

Left Ventricle ◽

Endurance Training ◽

Exercise Tolerance ◽

Collateral Circulation ◽

Left Ventricular ◽

Left Ventricular Ejection ◽

Test Duration ◽

Hemodynamic Parameters ◽

Ventricular Ejection Fraction

The presence of a well-developed collateral circulation in the area of the artery responsible for the infarction improves the prognosis of patients and leads to a smaller area of infarction. One of the factors influencing the formation of collateral circulation is hypoxia, which induces angiogenesis and arteriogenesis, which in turn cause the formation of new vessels. The aim of this study was to assess the effect of endurance training conducted under normobaric hypoxia in patients after myocardial infarction at the level of exercise tolerance and hemodynamic parameters of the left ventricle. Thirty-five patients aged 43–74 (60.48 ± 4.36) years who underwent angioplasty with stent implantation were examined. The program included 21 training units lasting about 90 min. A statistically significant improvement in exercise tolerance assessed with the cardiopulmonary exercise test (CPET) was observed: test duration (p < 0.001), distance covered (p < 0.001), HRmax (p = 0.039), maximal systolic blood pressure (SBPmax) (p = 0.044), peak minute ventilation (VE) (p = 0.004) and breathing frequency (BF) (p = 0.044). Favorable changes in left ventricular hemodynamic parameters were found for left ventricular end-diastolic dimension LVEDD (p = 0.002), left ventricular end-systolic dimension LVESD (p = 0.015), left ventricular ejection fraction (LVEF) (p = 0.021), lateral e’ (p < 0.001), septal e’ (p = 0.001), and E/A (p = 0.047). Endurance training conducted in hypoxic conditions has a positive effect on exercise tolerance and the hemodynamic indicators of the left ventricle.

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