Correlation Between Ischaemia Modified Albumin Level And Coronary Collateral Circulation
Abstract Abstract Objective: To investigate the correlation between ischaemia modified albumin(IMA) level and coronary collateral circulation(CCC) in patients with chronic total occlusive disease(CTO).Methods: Coronary angiography was performed in the Department of Cardiology, Zhongnan Hospital of Wuhan University from 2017-08 to 2019-02 to determine 128 patients with CTO lesions in at least one major coronary artery.According to the Rentrop evaluation criteria,the degree of CCC formation was divided into CCC poor formation group (Rentrop0-1grade,n=69)and CCC formation good group(Rentrop2-3grade,n=59).The IMA level of the patients was measured using an albumin-cobalt binding assay.Record and analyze the patient's general data, blood routine,total bilirubin(TBIL),blood lipids,uric acid (UA),left ventricular ejection fraction(LVEF) and other indicators,while recording the patient's occlusion of blood vessels.Results: The proportion of platelet count and diabetes in the poor CCC group was higher than that in the good group (P<0.05).The ratio of ischemic modified albumin and total bilirubin in the poor CCC group was lower than that in the good group (P<0.05).Multivariate logistic regression analysis showed that ischemic modified albumin was positively correlated with CCC formation[OR=1.190,95%CI(1.092-1.297),P<0.001],diabetes was negatively correlated with CCC formation[OR=0.285,95%CI(0.094-0.864),P<0.05].Ischemic modified albumin predicts good formation of CCC under the ROC curve and the area under the ROC curve is 0.769(95%CI:0.686-0.851,P<0.001);the optimal cut-off value was 63.35KU/L,the sensitivity is 71.2%,specificity is 71%.Conclusion: The IMA level is closely related to the good formation of CCC.The higher IMA level can be used as an effective predictor of the good CCC formation in CTO.