scholarly journals Small cell carcinoma of the vulva: case report

2017 ◽  
Vol 7 (2) ◽  
Author(s):  
Ana Correia ◽  
Elizabeth Castelo Branco ◽  
Paulo Correia ◽  
Marcos Guimarães ◽  
Luís Sá
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Case Reports ◽  
Neuroendocrine Differentiation ◽  
Small Cell ◽  
Adjuvant Radiation ◽  
Therapeutic Approaches ◽  
High Grade Carcinoma ◽  
Neuroendocrine Small Cell Carcinoma ◽  
Gynaecological Tumours

Neuroendocrine tumours are rare in the gynaecologic tract, comprising approximately 2% of all gynaecological tumours. They have an aggressive behaviour and are a diagnostic and clinical challenge, due to their rarity and the lack of standardized therapeutic approaches. There are a few case reports. It is defined as a high-grade carcinoma exhibiting neuroendocrine differentiation. The authors describe the case of a 70-year-old woman, with vulvar neuroendocrine small cell carcinoma after superficial vulvectomy. The patient was submitted to a surgery with wide local excision and adjuvant radiation therapy. A review of the literature on this topic is also presented.

scholarly journals Small Cell Carcinoma of the Uterine Cervix in a Pregnant Patient Diagnosed with Liquid Based Cytology and Cell Block Immunocytochemistry

2014 ◽  
Vol 2014 ◽  
pp. 1-5 ◽  
Author(s):  
Mawuli F. Attipoe ◽  
Charles D. Sturgis
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Uterine Cervix ◽  
Case Reports ◽  
Pregnant Patient ◽  
Small Cell ◽  
Tumor Type ◽  
Cell Block ◽  
Current Case ◽  
Small Series

Definitive cytomorphologic diagnosis of small cell carcinoma of the uterine cervix is possible but can be challenging in routine cervicovaginal cancer screening specimens. Several small series of reported cases of cervical small cell carcinoma have shown this uncommon malignancy to represent fewer than 2% of all invasive cervical cancers. This tumor type is associated with poor prognosis and rapid disease progression and can develop to an advanced stage in the interval between screening visits. Only rare case reports of small cell carcinoma arising in gravid cervices are known. In the current case a 29-year-old, gravida 6, para 2, pregnant (10-week gestation) female presented with postcoital bleeding. A definitive diagnosis of small cell carcinoma of the cervix was made possible by liquid based Pap testing with ancillary cell block preparation allowing for immunocytochemical characterization of the lesional cell population.

scholarly journals Distal Humerus as Delayed Site of Metastasis from Small Cell Carcinoma of Gallbladder

2013 ◽  
Vol 2013 ◽  
pp. 1-4 ◽  
Author(s):  
Mutahir A. Tunio ◽  
Mushabbab AlAsiri ◽  
Asma Mohammed F. Ali ◽  
Eyad Fawzi AlSaeed ◽  
Muhammad Shuja ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
World Literature ◽  
Case Reports ◽  
Locally Advanced ◽  
Distal Humerus ◽  
Small Cell ◽  
Rare Entity ◽  
Dismal Prognosis ◽  
Advanced Stages

Background. Small cell carcinoma (SCC) of the gallbladder is a rare entity and is often seen in elderly women. SCC of gallbladder is typically a nonsecretory carcinoid tumor without overt clinical symptoms and is often discovered at advanced stages. SCC of gallbladder carries a dismal prognosis as compared to SCC of lung and adenocarcinoma of gallbladder. To date, only 73 case reports have been published in the world literature.Case Presentation. Herein, we report a case of a 73-year-old Saudi woman who presented with one week history of right upper quadrant abdominal pain and obstructive jaundice and was found to be a case of locally advanced, metastatic SCC of gallbladder cT4N1M1 (liver, para-aortic lymph nodes, and bone). The patient was treated with neoadjuvant etoposide and cisplatin (EP) chemotherapy three cycles after biliary stenting followed by radical cholecystectomy, lymphadenectomy, and adjuvant EP chemotherapy and then one year later developed distal humerus osseous metastasis.Conclusion. SCC of the gallbladder is very rare entity and is often seen at advanced stages. Osseous metastases of peripheral skeleton from SCC gallbladder are rarely reported. Surgery is curative option but only for early stage tumors. Incorporation of chemotherapy along with radical resection increases the survival.

scholarly journals Small Cell Carcinoma of the Prostate in an Elderly Patient: A Case Report and Review of the Literature

Rare Tumors ◽  
2016 ◽  
Vol 8 (4) ◽  
pp. 176-178 ◽  
Author(s):  
Dale Alan Whitaker ◽  
Daniel H. Miller ◽  
Niveditha Jagadesh ◽  
Gerald W. Strong ◽  
Lauren Hintenlang ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Current Knowledge ◽  
Case Reports ◽  
The United States ◽  
Small Cell ◽  
Rapid Progression ◽  
Retrospective Case

Prostate cancer is the most common malignancy of men in the United States. Small-cell carcinoma (SCC), which typically presents as an aggressive lung malignancy, is a rare diagnosis within the setting of prostate cancer pathology. Due to its limited prevalence, little information regarding the treatment and prognosis of this disease in large populations is available. To date our current knowledge base is largely limited to case reports and retrospective case reviews. The mainstay of treatment for this particular histology most often involves a multimodality approach utilizing chemotherapy in conjunction with radiation therapy, androgen deprivation therapy, or prostatectomy. Here we present the case of an elderly 89-year-old Caucasian male who was diagnosed with SCC of the prostate. Despite proceeding with a course of definitive radiotherapy, the patient experienced rapid progression of disease and ultimately elected to discontinue radiation therapy and receive hospice care.

Neuroendocrine small cell carcinoma of the breast: report of a case

2009 ◽  
Vol 42 (1) ◽  
pp. 58-61 ◽  
Author(s):  
Rin Yamaguchi ◽  
Maki Tanaka ◽  
Hiroko Otsuka ◽  
Miki Yamaguchi ◽  
Yuko Kaneko ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Carcinoma Of The Breast ◽  
Neuroendocrine Small Cell Carcinoma

Establishment and Characterization of a New Cell Line (SKS) from Neuroendocrine Small Cell Carcinoma of the Uterine Cervix and Its Chemosensitivity

Oncology ◽  
2001 ◽  
Vol 60 (4) ◽  
pp. 367-372 ◽  
Author(s):  
Yasushi Saga ◽  
Mitsuaki Suzuki ◽  
Natsuko Tamura ◽  
Michitaka Ohwada ◽  
Ikuo Sato
Keyword(s):  
Cell Carcinoma ◽  
Cell Line ◽  
Small Cell Carcinoma ◽  
Uterine Cervix ◽  
Small Cell ◽  
New Cell Line ◽  
Neuroendocrine Small Cell Carcinoma

scholarly journals A case of MPO- and PR3-ANCA-negative pauci-immune renal-limited small-vessel vasculitis associated with endometrial neuroendocrine small cell carcinoma

2013 ◽  
Vol 2 (1) ◽  
pp. 123-127 ◽  
Author(s):  
Shuzo Kaneko ◽  
Yusuke Tsukamoto ◽  
Kazuya Abe ◽  
Masayuki Yonamine ◽  
Sumiko Hasegawa ◽  
...  
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Small Vessel ◽  
Small Vessel Vasculitis ◽  
Neuroendocrine Small Cell Carcinoma

Exfoliative Cytology of Neuroendocrine Small Cell Carcinoma of the Endometrium

1998 ◽  
Vol 42 (4) ◽  
pp. 978-982 ◽  
Author(s):  
Daniela Proca ◽  
Sedigheh Keyhani-Rofagha ◽  
Larry J. Copeland ◽  
Arif Hameed
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Small Cell ◽  
Exfoliative Cytology ◽  
Neuroendocrine Small Cell Carcinoma

Mechanisms of Neuroendocrine Differentiation in Pulmonary Neuroendocrine Cells and Small Cell Carcinoma

2003 ◽  
Vol 14 (2) ◽  
pp. 133-140 ◽  
Author(s):  
Takaaki Ito ◽  
Naoko Udaka ◽  
Kohji Okudela ◽  
Takuya Yazawa ◽  
Hitoshi Kitamura
Keyword(s):  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Neuroendocrine Differentiation ◽  
Small Cell ◽  
Neuroendocrine Cells ◽  
Pulmonary Neuroendocrine Cells

scholarly journals Small Cell Carcinoma of the Gallbladder: Case Report and Comprehensive Analysis of Published Cases

2015 ◽  
Vol 2015 ◽  
pp. 1-8 ◽  
Author(s):  
Carolyn Carrera ◽  
Paul Kunk ◽  
Osama Rahma
Keyword(s):  
Overall Survival ◽  
Case Report ◽  
Cell Carcinoma ◽  
Small Cell Carcinoma ◽  
Metastatic Disease ◽  
Median Overall Survival ◽  
Case Reports ◽  
Small Cell ◽  
Carcinoma Of The Gallbladder ◽  
Local Disease

Background. Gallbladder small cell carcinoma is a rare and highly aggressive malignancy with no established standard of care treatment. We described here a case report of small cell gallbladder cancer and we then performed a comprehensive review of 72 case reports of this disease.Methods. Published case reports of small cell carcinoma of the gallbladder between 1983 and 2014 were reviewed. Treatment modalities and survival were analyzed for metastatic and localized disease.Results. Median overall survival for all patients was 13 months. Metastatic disease was identified in 72% of cases. Treatment of metastatic disease with chemotherapy showed a significant survival benefit (p<0.001) compared to no chemotherapy, and the use of platinum doublet with etoposide showed a nonsignificant 4-month improvement in survival compared to other chemotherapy regimens (p=0.13). Adjuvant therapy did not demonstrate an improvement of median overall survival in local disease (p=0.78).Conclusion. Given the limited available data, systemic therapy with platinum and etoposide should be considered for patients with metastatic small cell carcinoma of the gallbladder. Adjuvant chemoradiation or chemotherapy for treatment of local disease warrants further investigation.

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