scholarly journals Innervation of the thoracolumbar fascia

2019 ◽  
Vol 29 (3) ◽  
Author(s):  
Siegfried Mense
Keyword(s):  
Nerve Ending ◽  
Nerve Endings ◽  
Sterile Inflammation ◽  
Low Back ◽  
Nerve Fibres ◽  
Thoracolumbar Fascia ◽  
Free Nerve Endings ◽  
Mechanical Threshold ◽  
Calcitonin Gene ◽  
Sensory Functions

The aim of the study was to obtain information on the sensory functions of the thoracolumbar fascia (TLF). The types of nerve fibres present in the TLF were visualized with specific antibodies to neuropeptides and sympathetic fibres. Most data were obtained from the TLF in rats, but some findings from the human fascia are also included. The only receptive nerve ending found was the free nerve ending, i.e. no corpuscular receptors existed in our specimen. An exclusive innervation with free nerve endings speaks for a nociceptive function, but the TLF may also fulfill proprioceptive functions, since many of the free nerve endings have a low mechanical threshold. Most of the fibres could be visualized with antibodies to CGRP [calcitonin gene- related peptide (CGRP)] and SP [substance P (SP)]. The latter ones most likely were nociceptors. The TLF contained a great proportion of postganglionic sympathetic fibres, which may be vasoconstrictors. A comparison between an inflamed and intact fascia showed an increase of the CGRP- and SP-positive fibres in the inflamed TLF. This finding could be one explanation for the low back pain of many patients, since practically all lesions of the fascia are accompanied by a sterile inflammation.

scholarly journals Needle-nerve interaction in acupuncture: A morphological study.

2021 ◽  
Vol 24 (3) ◽  
pp. 324-333
Author(s):  
N. D. Dimitrov ◽  
D. Y. Atanasova ◽  
N. S. Tomov ◽  
N. L. Pirovsky ◽  
I. G. Ivanova ◽  
...  
Keyword(s):  
Mast Cells ◽  
Muscle Spindles ◽  
Systemic Effect ◽  
Hair Follicles ◽  
Nerve Endings ◽  
Sebaceous Glands ◽  
Nerve Fibres ◽  
Free Nerve Endings ◽  
Needle Tract ◽  
Acupuncture Effects

Some acupuncture effects are considered to be caused by interaction with nerve structures in and around the acupoints. The aim of the present study was to investigate the nerve structures that interact with the needle in acupuncture and to present their distribution in acupoint tissues. To do this, the microscopic anatomy and its alterations in the vicinity of the needle tract formed after experimental acupuncture in ST36 acupoint in rats were described by histological and immunohistochemical methods. Free nerve endings were seen in the epidermis, and surrounding hair follicles and sebaceous glands in the dermis. Muscle spindles and larger nerve fibres close to blood vessels were also observed deeper, in the muscular plane. Needling of the acupoint caused destruction and displacement of hair follicles together with their free nerve endings. Deeper, some muscle spindles and smaller nerves were displaced and disrupted. Larger nerves were not destroyed, but rather pushed aside by the needle. Furthermore, needle impact also caused degranulation of mast cells near the needle tract. The findings suggest multiple ways of interaction between acupuncture needle and the nerve structures of the acupoint. Acupuncture combines destruction, disruption and displacement of nerve structures, together with additional interaction with mast cells. Those mechanisms are involved in eliciting the needling sensation and are possibly associated with the systemic effect of acupuncture.

Histopathological analysis of the synovium in trapeziometacarpal osteoarthritis

2019 ◽  
Vol 44 (10) ◽  
pp. 1079-1088
Author(s):  
Susanne Rein ◽  
Janet Okogbaa ◽  
Elisabet Hagert ◽  
Suzanne Manthey ◽  
Amy Ladd
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Endings ◽  
Histopathological Analysis ◽  
Low Grade ◽  
Free Nerve Endings ◽  
Related Peptide ◽  
Aspartate Receptor ◽  
Trapeziometacarpal Osteoarthritis ◽  
Calcitonin Gene

Dorsoradial and anterior oblique ligaments were harvested during surgery in 13 patients with symptomatic trapeziometacarpal osteoarthritis, which had been graded preoperatively by a modified Eaton-Littler radiographic grading. Ligaments, including the periligamentous synovium, were stained with S100 protein, neurotrophic receptor p75, protein gene product 9.5, calcitonin gene related peptide, acetylcholine, substance P, neuropeptide Y, noradrenaline, N-methyl-D-aspartate-receptor and Met/Leu-enkephalin. The synovium was classified as showing no, low-grade or high-grade synovitis. Free nerve endings had higher immunoreactivity for substance P than for N-methyl-D-aspartate-receptor, enkephalin and noradrenaline. The synovial stroma had less immunoreactivity for N-methyl-D-aspartate-receptor than for noradrenaline, substance P and calcitonin gene related peptide. There was no relation between the grade of osteoarthritis and the visual pain analogue scale, synovitis score, immunoreactivity of all antibodies and quantity of free nerve endings or blood vessels. Synovium in trapeziometacarpal joint osteoarthritis produces several neuromediators causing a polymodal neurogenic inflammation and which may serve as biomarkers for osteoarthritis or therapeutic targets.

Presence of calcitonin gene-related peptide (CGRP) and substance P (SP) immunoreactivity in intraepidermal free nerve endings of cat skin

1988 ◽  
Vol 442 (2) ◽  
pp. 391-395 ◽  
Author(s):  
Francisco J. Alvarez ◽  
Carmen Cervantes ◽  
Isabel Blanco ◽  
Rosa Villalba ◽  
Ricardo Martinez-Murillo ◽  
...  
Keyword(s):  
Substance P ◽  
Calcitonin Gene Related Peptide ◽  
Nerve Endings ◽  
Free Nerve Endings ◽  
Related Peptide ◽  
Calcitonin Gene

INTRAEPIDERMAL FREE NERVE ENDINGS IN GUINEA PIGS

1982 ◽  
Vol 9 (2) ◽  
pp. 107-116 ◽  
Author(s):  
Motoyuki Mihara ◽  
Ken Hashimoto ◽  
Masanobu Kumakiri
Keyword(s):  
Guinea Pigs ◽  
Nerve Endings ◽  
Free Nerve Endings

Competition during innervation of embryonic amphibian head skin

1983 ◽  
Vol 218 (1210) ◽  
pp. 49-59 ◽  
Keyword(s):  
Horseradish Peroxidase ◽  
Xenopus Laevis ◽  
Trigeminal Ganglion ◽  
Nerve Endings ◽  
Movement Detector ◽  
Dorsal Midline ◽  
Intact Side ◽  
Free Nerve Endings ◽  
Peripheral Innervation ◽  
Peripheral Sensory

We have examined the initial innervation of the head skin in Xenopus laevis embryos which is by two classes of trigeminal mechanoreceptor with beaded ‘free’ nerve-endings. By recording receptive areas electrophysiologically and staining peripheral sensory neurites with horseradish peroxidase, we have shown that ‘movement detector’ neurites from one trigeminal ganglion do not normally cross the dorsal midline of the head to innervate areas of skin on the opposite side. However, if one trigeminal ganglion is removed before peripheral innervation starts, movement detector neurites from the intact side will now cross the midline to innervate contralateral skin. These observations suggest a specific competitive interaction between movement detector neurites during their innervation of head skin. The second class of receptor, ‘rapid transient’ detectors, have a different pattern of innervation, crossing the midline in both normal and operated animals.

scholarly journals Binding of 1,1,1-trichloro-2,2-di-p-chlorophenylethane (DDT) with subcellular fractions of rat brain

1969 ◽  
Vol 114 (1) ◽  
pp. 135-139 ◽  
Author(s):  
Hans Brunnert ◽  
Fumio Matsumura
Keyword(s):  
Rat Brain ◽  
Nerve Ending ◽  
Soluble Proteins ◽  
Subcellular Fractions ◽  
Nerve Endings ◽  
Sephadex Column ◽  
Column Method ◽  
Synaptic Complexes ◽  
Soluble Components

DDT (1,1,1-trichloro-2,2-di-p-chlorophenylethane) and DDE (1,1-dichloro-2,2-di-p-chlorophenylethylene, a non-insecticidal analogue of DDT) were found to bind with various nerve components of rat brain. The amount of DDT binding exceeded that of DDE only in the fraction containing mainly the nerve endings. Among various components in the nerve-ending fraction, a subfraction containing mainly the pre- and post-synaptic complexes had the highest affinity for DDT in comparison with that for DDE. By using an ‘acetone-powdering’ technique on brain preparations, the Sephadex-column method was shown to provide reliable results for studies on the binding of DDT or DDE with soluble proteins in the nerve tissues. From these results it was concluded that DDE had a higher affinity for soluble components of the rat brain than did DDT.

Thoracolumbar Fascia Enthesopathy as a Cause of Low Back Pain: A Retrospective and Follow-up Study

2021 ◽  
Author(s):  
Ouidade A. Tabesh ◽  
Roba Ghossan ◽  
Soha H Zebouni ◽  
Rafic Faddoul ◽  
Michel Revel ◽  
...  
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Iliac Crest ◽  
Pain Syndrome ◽  
Clinical Findings ◽  
Complete Relief ◽  
Low Back ◽  
Thoracolumbar Fascia ◽  
The Mean

Abstract Aim. To evaluate ultrasonography findings of Thoracolumbar Fascia (TLF) enthesis in patients with low back pain (LBP) due to iliac crest pain syndrome (ICPS). Method. The ultrasonographic and clinical findings of 60 patients with LBP due to ICPS were compared to those of 30 healthy volunteers with no LBP. Thickness of the TLF was measured with ultrasound (US) at its insertion on the iliac crest. Results. Forty-eight women and 12 men with a mean age of 42.1±11.3 years were diagnosed with ICPS. In patients, the mean thickness of the TLF was 2.51±0.70mm in affected sides compared to 1.81±0.44mm in the contralateral unaffected sides. The mean thickness difference of 0.82mm between the affected and non-affected sides was statistically significant (95%CI, 0.64-0.99, P<0.0001). In volunteers, the mean thickness of the TLF was 1.6±0.2mm. The mean thickness difference of 0.89mm between the affected sides of patients and volunteers was statistically significant (95%CI, 0.73-1.06, P<0.0001). Forty-two patients who didn’t improve with conservative therapy, received injections of methylprednisolone acetate and 1% lidocaine around the TLF enthesis. All patients reported complete relief of their LBP within 20 minutes of the injections thanks to the lidocaine anesthetic effect. Fifty-six (93.3%) patients were reached by phone for a long-term follow-up. Among them, 33 (58.9%) patients experienced a sustained complete pain relief after a mean follow-up of 45±19.3 months (range, 3-74 months). Conclusion. our findings suggest that TLF enthesopathy is a potential cause of nonspecific LBP that can be diagnosed using US.

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