scholarly journals Kikuchi-Fujimoto disease involving retroperitoneal lymph nodes: An uncommon presentation

2021 ◽  
Vol 13 (1) ◽  
Author(s):  
Jane Date Hon ◽  
Maria Vergara-Lluri ◽  
Imran Siddiqi ◽  
Christopher Foss ◽  
Donald Feinstein ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Abdominal Pain ◽  
Lymph Nodes ◽  
Fever Of Unknown Origin ◽  
Cervical Lymphadenopathy ◽  
Unknown Origin ◽  
Unknown Etiology ◽  
Limited Disease ◽  
Uncommon Presentation ◽  
Cervical Disease

Kikuchi-Fujimoto disease is a self-limited disease of unknown etiology that is clinically defined by fevers accompanied by tender posterior cervical lymphadenopathy. It often presents acutely or sub-acutely, and due to its non-specific features, the differential diagnosis is broad and includes infectious, autoimmune, and malignant causes. Although cases of extra-cervical disease are not uncommon, involvement of retroperitoneal lymph nodes has only rarely been reported. Here, we describe a patient with Kikuchi-Fujimoto disease who presented with fever of unknown origin, abdominal pain, and enlarged hypermetabolic retroperitoneal lymph nodes.

Pyogenic Liver Abscess in Normal Children With Fever of Unknown Origin

PEDIATRICS ◽  
1976 ◽  
Vol 58 (4) ◽  
pp. 614-616 ◽  
Author(s):  
Sheldon L. Kaplan ◽  
Ralph D. Feigin
Keyword(s):  
Abdominal Pain ◽  
Liver Abscess ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Pyogenic Liver Abscess ◽  
Liver Function Tests ◽  
Blood Cultures ◽  
Normal Children ◽  
The Past ◽  
Liver Abscesses

Solitary pyogenic hepatic abscesses were identified as the cause of fever, abdominal pain, and hepatomegaly in two otherwise normal children who were seen at St. Louis Children's Hospital during the past year. Liver function tests were normal and blood cultures were negative in both patients. These cases illustrate that pyogenic liver abscess may occur in normal children and should be considered whenever fever of unknown origin is associated with abdominal complaints. Only in this way can we hope to improve upon the results cited previously, namely that the majority of liver abscesses remain undiagnosed during life.

scholarly journals A Rare Cause of Abdominal Pain and Fever of Unknown Origin: Takayasu Arteritis

2019 ◽  
Author(s):  
Özlem Üzüm ◽  
Muhammed Ali Kanık ◽  
Kader Vardı ◽  
Yeliz Pekçevik ◽  
Kayı Eliaçık ◽  
...  
Keyword(s):  
Abdominal Pain ◽  
Takayasu Arteritis ◽  
Fever Of Unknown Origin ◽  
Unknown Origin

scholarly journals Mystery of neck lump: an uncommon presentation of urachal cancer

2019 ◽  
Vol 12 (8) ◽  
pp. e230215 ◽  
Author(s):  
Kamal Kant Sahu ◽  
Deepali Pandey ◽  
Ajay Kumar Mishra ◽  
James O’Shea ◽  
Yayan Chen ◽  
...  
Keyword(s):  
Bladder Tumour ◽  
Cervical Lymphadenopathy ◽  
Unknown Origin ◽  
Excisional Biopsy ◽  
Signet Ring Cell ◽  
High Dose ◽  
Uncommon Presentation ◽  
Signet Ring ◽  
Urachal Cancer ◽  
Adenocarcinoma Of Unknown Origin

We present the case of a 55-year-old male patient who presented with palpable cervical lymphadenopathy. Excisional biopsy showed metastatic adenocarcinoma of unknown origin. Imaging showed a bladder mass following which he underwent transurethral resection of bladder tumour. Histopathological evaluation of mass confirmed a poorly differentiated adenocarcinoma with signet-ring cell features. Immunohistochemistry was suggestive of metastatic urachal cancer. He agreed for enrollment in a clinical trial, however soon after 1st cycle, he developed immune pneumonitis requiring high dose steroids. On follow-up, MRI brain was done for evaluation of headache which showed metastatic intracranial disease. He completed radiotherapy following which he was started on FOLFOX chemo regimen (folinic acid, 5-fluorouracil and oxaliplatin).

Fever of Unknown Origin Due to Inflammatory Pseudotumour of Lymph Nodes

1998 ◽  
Vol 53 (6) ◽  
pp. 367-370 ◽  
Author(s):  
D.C. Knockaert ◽  
A. Schuermans ◽  
J. Vlayen ◽  
Chris Dewolf-Peeters ◽  
H.J. Bobbaers
Keyword(s):  
Lymph Nodes ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Inflammatory Pseudotumour

Patients with Fever of Unknown Origin and Splenomegaly: Diagnostic Value of Splenectomy and Preoperative Risk Factors Suggestive of Underlying Lymphomas

2017 ◽  
Vol 137 (4) ◽  
pp. 240-246
Author(s):  
Lu Zhang ◽  
Wei Zhang ◽  
Huacong Cai ◽  
Xinxin Cao ◽  
Miao Chen ◽  
...  
Keyword(s):  
Risk Factors ◽  
Lymph Nodes ◽  
Hodgkin Lymphoma ◽  
Fever Of Unknown Origin ◽  
Characteristic Curve ◽  
Unknown Origin ◽  
Final Diagnosis ◽  
Diagnostic Value ◽  
Discrimination Power ◽  
Non Hodgkin Lymphoma

Background: We reviewed patients with fever of unknown origin (FUO) and splenomegaly and assessed the diagnostic value of splenectomy and measured risk factors suggestive of an underlying lymphoma. Methods: FUO patients (n = 83) who had splenomegaly and underwent splenectomy were enrolled into this retrospective single-center study. Clinical presentations were documented and risk factors suggestive of an underlying lymphoma were tested. Results: Seventy-four patients (89.2%) had a diagnosis of lymphoma or not after splenectomy and follow-up. Of those (55.4%) diagnosed with lymphoma, 29 had B-cell non-Hodgkin lymphoma and 12 had T-cell non-Hodgkin lymphoma. The remaining 33 (44.6%) had diseases other than lymphoma. Using multivariate logistic analysis, the following 3 independent risk factors were found to be related to a final diagnosis of lymphoma: age (continuous) (HR 1.086; 95% CI 1.033-1.141; p = 0.001), massively enlarged spleen (HR 7.797; 95% CI 1.267-47.959; p = 0.027), and enlarged intra-abdominal lymph nodes (HR 63.925; 95% CI 7.962-513.219; p < 0.001). The calibration of the model was satisfactory (p = 0.248 using the Hosmer-Lemeshow test), and the discrimination power was good (area under the receiver operating characteristic curve 0.925; 95% CI 0.863-0.987). Conclusions: Splenectomy is an effective diagnostic procedure for patients with FUO and splenomegaly and lymphoma is a common cause. Older age, a massively enlarged spleen, and enlarged intra-abdominal lymph nodes are risk factors suggesting an underlying lymphoma, and surgery for high-risk patients should be considered.

scholarly journals Clinical Features, Histopathology and Differential Diagnosis of Sarcoidosis

Cells ◽  
2021 ◽  
Vol 11 (1) ◽  
pp. 59
Author(s):  
Claudio Tana ◽  
Iginio Donatiello ◽  
Alessandro Caputo ◽  
Marco Tana ◽  
Teresa Naccarelli ◽  
...  
Keyword(s):  
Differential Diagnosis ◽  
Clinical Practice ◽  
Lymph Nodes ◽  
Clinical Features ◽  
Routine Clinical Practice ◽  
The Other ◽  
Unknown Etiology ◽  
Histopathological Findings ◽  
Clinical Pictures ◽  
Granulomatous Disorders

Sarcoidosis is a chameleon disease of unknown etiology, characterized by the growth of non-necrotizing and non-caseating granulomas and manifesting with clinical pictures that vary on the basis of the organs that are mainly affected. Lungs and intrathoracic lymph nodes are the sites that are most often involved, but virtually no organ is spared from this disease. Histopathology is distinctive but not pathognomonic, since the findings can be found also in other granulomatous disorders. The knowledge of these findings is important because it could be helpful to differentiate sarcoidosis from the other granulomatous-related diseases. This review aims at illustrating the main clinical and histopathological findings that could help clinicians in their routine clinical practice.

scholarly journals A Physician’s Nightmare: Fever of Unknown Origin

2016 ◽  
Vol 2016 ◽  
pp. 1-3
Author(s):  
Sana Din ◽  
Farrukh Anwer ◽  
Mirza Beg
Keyword(s):  
Abdominal Pain ◽  
Marked Improvement ◽  
Fever Of Unknown Origin ◽  
Unknown Origin ◽  
Wandering Spleen ◽  
Recurrent Fever ◽  
High Fiber ◽  
Fiber Diet ◽  
High Fiber Diet ◽  
Diagnostic Technologies

Fever of unknown origin (FUO) remains to be a challenge despite advancement in diagnostic technologies and procedures. FUO is considered when fever presents intermittently without an explanation. It has been linked to various etiologies, which makes it difficult to diagnose. We present the case of 18-month-old female with recurrent fever, splenomegaly, abdominal pain, and constipation. The workup for her symptoms revealed wandering spleen. Wandering spleen is a result from excessive laxity or absence of splenic ligaments. The patient underwent splenectomy and was advised to continue on Senna, Miralax, and high fiber diet. Her mother reported that the fever is no longer present and there is marked improvement in her constipation and abdominal pain after splenectomy.

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