scholarly journals Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature

2018 ◽  
Vol 12 (4) ◽  
pp. 276-279
Author(s):  
Nathan Artom ◽  
Marcello Brignone ◽  
Luca Paris ◽  
Anna Lisa Garlaschelli ◽  
Marina Cavaliere ◽  
...  
Keyword(s):  
Lymph Node ◽  
Previous History ◽  
Castleman Disease ◽  
Lymphoid Tissues ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
History Of ◽  
Systemic Symptoms ◽  
Inflammatory Syndrome ◽  
Lymph Node Hyperplasia

Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD.

scholarly journals Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report

2020 ◽  
Vol 12 (03) ◽  
pp. 225-229
Author(s):  
Timothy Amos Ekwere ◽  
Uchechukwu Brian Eziagu
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Cell Types ◽  
Lymph Node Biopsy ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Human Herpes Virus 8 ◽  
Systemic Symptoms

AbstractCastleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.

Rare Case of Castleman Disease Involving the Pancreas

2007 ◽  
Vol 73 (12) ◽  
pp. 1284-1287 ◽  
Author(s):  
Vonny W. Tunru-Dinh ◽  
Abdul Ghani ◽  
Yuel D. Tom
Keyword(s):  
Lymph Node ◽  
Pancreatic Neoplasm ◽  
Signs And Symptoms ◽  
Castleman Disease ◽  
Pancreatic Mass ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Vascular Type ◽  
Common Location ◽  
Hyaline Vascular Type ◽  
History Of

Castleman disease, also known as angiofollicular lymph node hyperplasia, is an uncommon tumor involving lymph node tissues. The most common location is in the thorax presenting as a mediastinal mass. In the abdomen, most of the lesions are located in the pelvis, mesentery, and retroperitoneum. Only nine other cases of Castleman disease involving the pancreas have been described. We report a case of Castleman disease (hyaline vascular type) presenting as a pancreatic mass and an enlarged spleen. A 23-year-old woman presented with a 2-month history of abdominal pain localized to the left upper quadrant. Ultrasound and CT demonstrated a large retrogastric pancreatic mass and an enlarged spleen. Distal pancreatectomy and splenectomy were performed. Histopathologic examination revealed a markedly enlarged lymph node showing germinal centers with hyalinization and prominent follicular dendritic cells meshwork surrounded by concentric layers of small lymphocytes. Within the interfollicular area were regions of increased vascularity. BCL2, CD20, and CD79a show expanded mantle zones with a concentric targetoid arrangement of small lymphocytes. This is a case of unicentric Castleman disease of the hyaline-vascular type, which presented with signs and symptoms of a primary pancreatic neoplasm.

scholarly journals A Case Report of Unicentric Castleman Disease

2015 ◽  
Vol 23 (2) ◽  
pp. 256-258
Author(s):  
Mafruha Akter ◽  
Ibrahim Khalil ◽  
Golam Nabi ◽  
Syed Zakir Hossain ◽  
Md Uzzwal Mallik ◽  
...  
Keyword(s):  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Good Prognosis ◽  
Castleman Disease ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
Medical College

Castleman disease (CD) or angiofollicular lymph node hyperplasia is an uncommon benign lymphoproliferative disorder. Sometimes it is related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV). Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyalinevascular, plasma cell, and a mixed variant.We report the case of a 22-year-old young man who was diagnosed as unicentric Castleman Disease. We found on routine physical examination a mass localized in the left abdomen without clinically important constitutional symptoms for 3 years. Abdominal ultrasound and computed tomography scans revealed minimally enhancing soft tissue density lesion & it was seen in the left para aortic region measuring about 71mm x 42 mm in size. The patient subse-quently underwent an exploratory laparotomy. After opening of the abdomen, a lump measuring about 8 cm x 5 cm was found in the mesentery. The whole lump was dissected out and the gap in the mesentery was closed. No other lymphadenopathy was found. The specimen was sent for histopathology which revealed Castleman disease, plasma cell type. The patient completely recovered after surgery. Castleman disease is commonly misdiagnosed as malignant lymphoma, lymphadenitis or ectopic thymoma. So far, its diagnosis is mainly achieved via histopathological examination of surgically obtained tissue. Local or unicentric CD has a good prognosis if surgically excised properly.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 256-258

Castleman Disease In Children: Diagnosis and Treatment

2020 ◽  
Author(s):  
Hung Dinh Viet
Keyword(s):  
Lymph Node ◽  
Postoperative Period ◽  
Case Reports ◽  
Abdominal Mass ◽  
Clinical Manifestations ◽  
Castleman Disease ◽  
Results Of Treatment ◽  
Benign Lymph Node ◽  
Lymph Node Hyperplasia

Background: We describe the experiences in diagnosis and results of treatment in pediatric Castleman disease. Method: Serial case reports. Result: From 2016 to 2019, we had 7 cases of pediatric Castleman disease: 3 boys and 4 girl. The median age at diagnosis was 147 months (121-173 months). Clinical manifestations were found in five cases. They were all unicentric Castleman disease (6 abdominal mass, one left infraclavicular mass). All patients were operated with postoperative period uneventful. The median time of postoperative follow up was 22.7 months (11-53 months) with no signs of relapse. Conclusions: Pediatric Castleman disease is a rare benign lymph node hyperplasia, it can be localised or disseminated. Operation is the treatment of choice for localised Castleman disease.

scholarly journals A Rare Case of HHV-8 Associated Hemophagocytic Lymphohistiocytosis in a Stable HIV Patient

2019 ◽  
Vol 2019 ◽  
pp. 1-3
Author(s):  
Nonso Osakwe ◽  
Diane Johnson ◽  
Natalie Klein ◽  
Dalia Abdel Azim
Keyword(s):  
Hemophagocytic Lymphohistiocytosis ◽  
Rare Case ◽  
Viral Infections ◽  
Rare Condition ◽  
Lymph Node Biopsy ◽  
Castleman Disease ◽  
Human Herpes Virus 8 ◽  
Case Presentation ◽  
Multicentric Castleman Disease ◽  
History Of

Background. Hemophagocytic lymphohistiocytosis (HLH) is a rare condition associated with viral infections including HIV. Cases have been reported mainly in advanced HIV/AIDS. This is a rare case that reports HLH associated with human herpes virus-8 (HHV-8) associated multicentric Castleman disease in a stable HIV patient. Case Presentation. A 70-year-old Asian male patient with history of stable HIV on medications with CD 4 cell count above 200 presented with cough and fever and was initially treated for pneumonia as an outpatient. Persisting symptoms prompted presentation to the hospital. The patient was found to have anemia which persisted despite repeated transfusion of packed red cells. A bone marrow biopsy to investigate anemia revealed hemophagocytosis. A CT scan revealed multiple enlarged lymph nodes and hepatosplenomegaly. An excisional lymph node biopsy revealed HHV-8 associated multicentric Castleman disease. The patient deteriorated despite initiation of treatment. Conclusion. HLH can occur at any stage of HIV, rapid diagnosis to identify possible underlying reactive infectious etiology and prompt initiation of treatment is crucial to survival.

scholarly journals ANGIOFOLLICULAR LYMPH-NODE HYPERPLASIA OF THE MEDIASTINUM

1964 ◽  
Vol 47 (1) ◽  
pp. 111-121 ◽  
Author(s):  
Carlo M. Veneziale ◽  
Lenore A. Sheridan ◽  
W. Spencer Payne ◽  
Edgar G. Harrison
Keyword(s):  
Lymph Node ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Lymph Node Hyperplasia
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