scholarly journals Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report

2020 ◽  
Vol 12 (03) ◽  
pp. 225-229
Author(s):  
Timothy Amos Ekwere ◽  
Uchechukwu Brian Eziagu
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Cell Types ◽  
Lymph Node Biopsy ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Human Herpes Virus 8 ◽  
Systemic Symptoms

AbstractCastleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.

scholarly journals A Case Report of Unicentric Castleman Disease

2015 ◽  
Vol 23 (2) ◽  
pp. 256-258
Author(s):  
Mafruha Akter ◽  
Ibrahim Khalil ◽  
Golam Nabi ◽  
Syed Zakir Hossain ◽  
Md Uzzwal Mallik ◽  
...  
Keyword(s):  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Good Prognosis ◽  
Castleman Disease ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
Medical College

Castleman disease (CD) or angiofollicular lymph node hyperplasia is an uncommon benign lymphoproliferative disorder. Sometimes it is related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV). Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyalinevascular, plasma cell, and a mixed variant.We report the case of a 22-year-old young man who was diagnosed as unicentric Castleman Disease. We found on routine physical examination a mass localized in the left abdomen without clinically important constitutional symptoms for 3 years. Abdominal ultrasound and computed tomography scans revealed minimally enhancing soft tissue density lesion & it was seen in the left para aortic region measuring about 71mm x 42 mm in size. The patient subse-quently underwent an exploratory laparotomy. After opening of the abdomen, a lump measuring about 8 cm x 5 cm was found in the mesentery. The whole lump was dissected out and the gap in the mesentery was closed. No other lymphadenopathy was found. The specimen was sent for histopathology which revealed Castleman disease, plasma cell type. The patient completely recovered after surgery. Castleman disease is commonly misdiagnosed as malignant lymphoma, lymphadenitis or ectopic thymoma. So far, its diagnosis is mainly achieved via histopathological examination of surgically obtained tissue. Local or unicentric CD has a good prognosis if surgically excised properly.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 256-258

scholarly journals Synchronous Unicentric Castleman Disease and Inflammatory Hepatocellular Adenoma: a Case Report

2018 ◽  
Vol 17 (5) ◽  
pp. 0-10
Author(s):  
Claudio De Vito ◽  
Thomas Papathomas G. ◽  
Federica Pedica ◽  
Pauline Kane ◽  
Ali Amir ◽  
...  
Keyword(s):  
Case Report ◽  
Ct Scan ◽  
Histological Examination ◽  
Plasma Cell ◽  
Hepatocellular Adenoma ◽  
Castleman Disease ◽  
Cell Type ◽  
Aa Amyloidosis ◽  
Plasma Cell Type ◽  
Systemic Symptoms

Systemic symptoms such as fever and fatigue are non-specific manifestations spanning from inflammation to neoplasia. Here we report the case of a 34 year-old man who presented with systemic symptoms for four months. CT-scan and MRI revealed a 3.4 cm arterialized hepatic lesion and a 7 cm paraduodenal mass. Surgical resection of both lesions and histological examination revealed an inflammatory hepatocellular adenoma and a unicentric plasma cell type of Castleman disease. Moreover, a diffuse AA amyloid deposition in the liver was observed. Resection of both lesions was associated with an improvement of the symptoms. To our knowledge, this is the first report of a synchronous presentation of a unicentric plasma cell type of Castleman disease, inflammatory hepatocellular adenoma and AA amyloidosis.

scholarly journals Abdominal localization of unicentric form of Castleman disease: A case report

2017 ◽  
Vol 74 (4) ◽  
pp. 367-370
Author(s):  
Bosko Milev ◽  
Borka Milev ◽  
Zoran Kostic ◽  
Darko Mirkovic ◽  
Nenad Perisic ◽  
...  
Keyword(s):  
Case Report ◽  
Plasma Cell ◽  
Castleman Disease ◽  
Mr Enterography ◽  
Unknown Etiology ◽  
Cell Type ◽  
Vascular Type ◽  
Hyaline Vascular Type ◽  
Plasma Cell Type ◽  
Golden Standard

Introduction. Castleman disease is a rare disease of the unknown etiology, occuring in two clinical forms: unicentric or multicentric. It is characterized by the hyperplasia of lymph glands. In literature the four pathohistological forms were described: hyaline vascular type, plasma cell type, mixed type and a recently recognized plasmablastic type. The most frequent changes are localized in the mediastinum, while the abdominal localization is with significatly rare occurrence, and that was the motive for presentation of this case. Case report. In a 41-year old male magnetic resonance (MR) enterography showed a change in the ileocecal area without the presence of subjective symptoms of digestive tract and without loss of body mass. Due to the suspicion of stromal tumor, surgical intervention was indicated. Pathohistological findings showed Castleman lymphadenopathia reactiva mesenterii (plasma cell type) which was in the unicentric form. There were present only anaemia and the increased value of sedimentation from the laboratory analyses. Conclusion. Abdominal localization of unicentric plasma cell form occurs rarely and the surgical method of treatment presents the golden standard as it was shown in the presented case.

scholarly journals Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature

2018 ◽  
Vol 12 (4) ◽  
pp. 276-279
Author(s):  
Nathan Artom ◽  
Marcello Brignone ◽  
Luca Paris ◽  
Anna Lisa Garlaschelli ◽  
Marina Cavaliere ◽  
...  
Keyword(s):  
Lymph Node ◽  
Previous History ◽  
Castleman Disease ◽  
Lymphoid Tissues ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
History Of ◽  
Systemic Symptoms ◽  
Inflammatory Syndrome ◽  
Lymph Node Hyperplasia

Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD.

scholarly journals Perigastric Hyaline-Vascular Variant Castleman’s Disease

2021 ◽  
pp. 632-638
Author(s):  
Yu Ming Jin ◽  
Gui Ying Jing
Keyword(s):  
Histopathological Examination ◽  
Immunohistochemical Analysis ◽  
Lymphoproliferative Disease ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Mesenchymal Tumors ◽  
Imaging Characteristics ◽  
Contrast Enhanced ◽  
Hyaline Vascular Variant ◽  
Vascular Variant

Castleman disease (CD) is a rare chronic lymphoproliferative disease with unknown etiology and pathogenesis disease. When the lesion is located in the mediastinum, the diagnosis of CD is easy. However, if the lesion presents as a perigastric mass mimicking other subserosal gastric mesenchymal tumors, the diagnosis can be challenging. As few sonographic manifestations of hyaline-vascular variant CD, especially contrast-enhanced ultrasound (CEUS) imaging, as well as computed tomography (CT) and histopathological imaging, have been reported in literature, this case may provide a vivid example of a comprehensive CEUS and CT usage in the diagnosis and surgery with regard to CD. This report presents a case of a 50-year-old female diagnosed with hyaline-vascular variant CD in a random physical examination, the ultrasound examination first revealed a 24.3 mm × 15.4 mm hypoechogenic lesion abutting the stomach, esophagus, and liver, which was under the suspicion of gastrointestinal stromal tumor. Following a series of medical examinations, including CEUS, CT, postoperative histopathological examination, and immunohistochemical analysis, the patient was diagnosed with hyaline-vascular variant unicentric CD. After the mass was completely excised through laparoscopic surgery, the woman recovered very well without recurrence during a follow-up period of 15 months. Thus, mastering ultrasound and CT-imaging characteristics of CD and applying ultrasound and CT examination together would do help to preoperative diagnosis.

scholarly journals Kikuchi-Fujimoto Disease: A Study Of 67 Cases From Coastal South India 

2020 ◽  
Author(s):  
Basavaprabhu Achappa ◽  
Nipuni Chamathka Herath ◽  
Jyoti Ramanath Kini ◽  
Ramesh Holla ◽  
Bodhi Sebastian ◽  
...  
Keyword(s):  
Clinical Presentation ◽  
Histopathological Examination ◽  
Cervical Lymphadenopathy ◽  
Symptomatic Treatment ◽  
Lymph Node Biopsy ◽  
Unknown Etiology ◽  
Extensive Literature ◽  
Cervical Lymphadenitis ◽  
Benign Condition ◽  
The Mean

Abstract Background Kikuchi-Fujimoto disease is a rare, benign condition, of unknown etiology, presenting as cervical lymphadenitis, usually tender and maybe associated with systemic symptoms. Despite the extensive literature on this disease, it continues to be misdiagnosed owing to its misleading clinical presentation. Results The mean age in our study was 26.9 (±11.3) years with a female majority of 65.7%. The clinical presentation of most cases was, tender swelling over the side of the neck ( n =50, 74.6%). On local examination, the mean length and width were 2.3 (±1.0) cm and 2.2 (±0.7) cm respectively. Histopathological examination revealed that most patients presented in the proliferative stage ( n =40, 59.7%). In 83.6% of the patients lymphadenopathy resolved in less than 2 months. Follow up of these patients over 9 months revealed that a vast majority of the patients underwent full recovery with symptomatic treatment ( n =42, 62.7%). Conclusions The disease is prevalent in young, female patients of Asian descent and often presents as cervical lymphadenopathy. Early diagnosis with excisional lymph node biopsy is crucial to avoid unnecessary investigations and treatment. Treatment is only symptomatic unless complicated, where steroid therapy is considered. Kikuchi’s disease has an excellent prognosis with almost no risk of fatality.

scholarly journals Fulminant Wegener's granulomatosis: A case report

2013 ◽  
Vol 70 (9) ◽  
pp. 887-890 ◽  
Author(s):  
Miroslav Dinic ◽  
Lidija Kandolf-Sekulovic ◽  
Lidija Zolotarevski ◽  
Rados Zecevic
Keyword(s):  
Case Report ◽  
Histopathological Examination ◽  
Systemic Vasculitis ◽  
Bowel Perforation ◽  
Exploratory Laparotomy ◽  
Unknown Etiology ◽  
Diffuse Peritonitis ◽  
Skin Sample ◽  
Skin Ulcers ◽  
Hemorrhagic Bullae

Introduction. Granulomatosis Wegener is anti-neutrophil cytoplasmic antibodies (ANCAs)-associated systemic vasculitis of unknown etiology. It is manifested as granulomatous necrotizing inflammation of the upper and lower parts of the respiratory tract, glomerulonephritis and systemic vasculitis involving most frequently the skin and oral mucous membrane. Sera markers of this disease are c-ANCA and p-ANCA. Case report. We presented a female patient aged 52 years with purpuric spots that had appeared on the lower legs ten months before admission to our hospital. The disease ran an aggressive course, and a month before admission hemorrhagic bullae, skin ulcers, hoarseness, dyspnea, generalized arthralgia, fatigue and fever had rapidly developed. Histopathological examination of a skin sample revealed necrotizing vasculitis, so that sera markers concentrations were elevated (c-ANCA, p-ANCA). There was a perforation of the nasal septum found on rhinoscopy. During hospitalization acute abdominal pain occurred, a possible tumor in the small intestine and possible granulomas in the liver were seen by multislice computed tomography (MSCT) examination, with normal findings on the lungs and kidneys. The treatment started with methylprednisolone: 500 mg/d i.v. infusion for consecutive 3 days, then 60 mg/d. On exploratory laparotomy small bowel perforation and diffuse peritonitis were found. Unstable in the postoperative period, the patient died on the day 12 of hospitalization. Conclusion. The reported patient was with fulminant Wegener?s granulomatosis, dominantly with skin changes and with gastrointestinal manifestation. This case accents the need for rapid systemic clinical evaluation in a severely ill patient with unclear diagnosis.

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