scholarly journals A Case Report of Unicentric Castleman Disease

2015 ◽  
Vol 23 (2) ◽  
pp. 256-258
Author(s):  
Mafruha Akter ◽  
Ibrahim Khalil ◽  
Golam Nabi ◽  
Syed Zakir Hossain ◽  
Md Uzzwal Mallik ◽  
...  
Keyword(s):  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Good Prognosis ◽  
Castleman Disease ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
Medical College

Castleman disease (CD) or angiofollicular lymph node hyperplasia is an uncommon benign lymphoproliferative disorder. Sometimes it is related to the chronic human herpes virus 8 (HHV-8) infection and the human immunodeficiency virus (HIV). Two clinical entities have been described: a unicentric presentation with the disease confined to a single anatomic lymph node and a multicentric presentation characterized by generalized lymphadenopathy and a more aggressive clinical course. Also, three histopathological subtypes have been described: hyalinevascular, plasma cell, and a mixed variant.We report the case of a 22-year-old young man who was diagnosed as unicentric Castleman Disease. We found on routine physical examination a mass localized in the left abdomen without clinically important constitutional symptoms for 3 years. Abdominal ultrasound and computed tomography scans revealed minimally enhancing soft tissue density lesion & it was seen in the left para aortic region measuring about 71mm x 42 mm in size. The patient subse-quently underwent an exploratory laparotomy. After opening of the abdomen, a lump measuring about 8 cm x 5 cm was found in the mesentery. The whole lump was dissected out and the gap in the mesentery was closed. No other lymphadenopathy was found. The specimen was sent for histopathology which revealed Castleman disease, plasma cell type. The patient completely recovered after surgery. Castleman disease is commonly misdiagnosed as malignant lymphoma, lymphadenitis or ectopic thymoma. So far, its diagnosis is mainly achieved via histopathological examination of surgically obtained tissue. Local or unicentric CD has a good prognosis if surgically excised properly.J Dhaka Medical College, Vol. 23, No.2, October, 2014, Page 256-258

scholarly journals Multicentric Plasma-Cell Type Castleman Disease Masquerading As Hodgkin Lymphoma: A Case Report

2020 ◽  
Vol 12 (03) ◽  
pp. 225-229
Author(s):  
Timothy Amos Ekwere ◽  
Uchechukwu Brian Eziagu
Keyword(s):  
Case Report ◽  
Lymph Node ◽  
Plasma Cell ◽  
Histopathological Examination ◽  
Cell Types ◽  
Lymph Node Biopsy ◽  
Castleman Disease ◽  
Unknown Etiology ◽  
Human Herpes Virus 8 ◽  
Systemic Symptoms

AbstractCastleman disease (CD), or angiofollicular hyperplasia, or giant lymph node hyperplasia, is a heterogeneous benign lymphoproliferative disorder of unknown etiology. It has three distinct histologic subtypes (hyaline vascular, plasma cell, and mixed hyaline vascular plasma cell types) as well as unicentric Castleman disease (UCD) and multicentric Castleman disease (MCD) variants. In the unicentric form, the disease is confined to one anatomical lymph node and usually with no systemic symptoms. However, in the multicentric form (further subdivided into idiopathic MCD, human herpes virus-8-associated MCD, and POEMS-associated MCD), lymphadenopathy is more generalized with more aggressive systemic symptoms mimicking a malignant lymphoma. Therefore, this case report aims to underscore the importance of immunohistochemical evaluation as an indispensable ancillary technique to routine histopathological examination of a lymph node biopsy specimen, as a gold standard for definitive diagnosis of proliferative lymph node lesions.

scholarly journals Variant of plasmablastic microlymphoma in Castleman disease: a case report and review of the literature

2018 ◽  
Vol 12 (4) ◽  
pp. 276-279
Author(s):  
Nathan Artom ◽  
Marcello Brignone ◽  
Luca Paris ◽  
Anna Lisa Garlaschelli ◽  
Marina Cavaliere ◽  
...  
Keyword(s):  
Lymph Node ◽  
Previous History ◽  
Castleman Disease ◽  
Lymphoid Tissues ◽  
Angiofollicular Lymph Node Hyperplasia ◽  
Human Herpes Virus 8 ◽  
History Of ◽  
Systemic Symptoms ◽  
Inflammatory Syndrome ◽  
Lymph Node Hyperplasia

Castleman disease (CD) is a rare lymphoproliferative disorder also known as angiofollicular lymph node hyperplasia or giant lymph node hyperplasia. CD can be unicentric CD (UCD) or multicentric CD (MCD). MCD affects more than one group of lymph nodes and/or lymphoid tissues and it is frequently associated with HIV and human herpes virus 8 (HHV-8) infections and, in contrast with UCD, it often results in systemic symptoms, such as fever, fatigue, anemia, inflammatory syndrome. HHV- 8-associated MCD recognizes HHV-8 as an etiopathogenetic agent and occurs generally in HIV-positive subjects. Our report describes an HHV-8 positive Castleman disease with plasmablastic microlymphoma occurring in a 51-year-old HIV seronegative woman, with a previous history of HBV infection and Kaposi’s sarcoma, who presented elevated procalcitonin levels during the acute phase of CD.

scholarly journals A case report of retroperitoneal Castleman disease

2013 ◽  
Vol 3 (3) ◽  
pp. 14 ◽  
Author(s):  
Peng Bo ◽  
Zheng Junhua ◽  
Gao Qiruo ◽  
Li Hong
Keyword(s):  
Histopathological Examination ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Castleman Disease ◽  
Magnetic Resonance Images ◽  
Retroperitoneal Mass ◽  
Solid Mass ◽  
Routine Physical Examination ◽  
Échographie Abdominale ◽  
The Right

Castleman disease (CD) is an uncommon lymphoproliferative disorderand is especially rare in the retroperitoneum or perirenalarea. We report the case of a 42-year-old woman in whom we foundon routine physical examination a mass localized in the rightabdomen without clinically important constitutional symptoms for30 days. Abdominal ultrasound, magnetic resonance images andcomputed tomography scans revealed a solid mass localized justbelow the right kidney in the retroperitoneum. The patient subsequentlyunderwent an exploratory laparotomy. Pathological examinationrevealed a right retroperitoneal mass of CD (hyaline vasculartype). The patient completely recovered after surgery. Castlemandisease is commonly misdiagnosed as malignant lymphoma,lymphadenitis or ectopic thymoma. So far, its diagnosis is mainlyachieved via histopathological examination of surgically obtainedtissue. After removal of the lesion, local CD has a good prognosis.La maladie de Castleman est un trouble lymphoprolifératif rare,surtout dans les régions rétropéritonéale ou périrénale. Nousdécrivons le cas d'une femme de 42 ans chez qui un examenphysique de routine a révélé la présence d'une masse localiséeau côté droit de l'abdomen sans que cette patiente n'affiche desymptômes constitutionnels d'importance clinique pendant 30 jours.Des images obtenues par échographie abdominale, par IRM et partomodensitométrie ont révélé la présence d'une masse solide situéejuste en dessous du rein droit dans la région rétropéritonéale. Lapatiente a ensuite subi une laparotomie exploratoire. L'examend'histopathologie a révélé une masse rétropéritonéale droite caractéristiquede la maladie de Castleman dans sa forme hyaline vasculaire.La patiente s'est complètement rétablie après l'intervention.Au moment du diagnostic, la maladie de Castleman est souventconfondue avec un lymphome malin, une lymphadénite ou un thymomeectopique. Jusqu'à présent, le diagnostic de cette maladieest posé principalement sur la base d'un examen histopathologiquede tissus prélevés par chirurgie. Après ablation de la masse, lepronostic lié à la maladie de Castleman est favorable.

scholarly journals Choledochal Cyst Coexisting with Gallbladder Carcinoma - An Uncommon Case Report

2017 ◽  
Vol 16 (4) ◽  
pp. 602-605
Author(s):  
Jahangir Hossain Bhuiyan ◽  
Mohibul Aziz ◽  
Omar Faruk ◽  
Mahbub Hasan
Keyword(s):  
Choledochal Cyst ◽  
Gallbladder Carcinoma ◽  
Medical Science ◽  
Rare Condition ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Low Grade ◽  
College Hospital ◽  
Medical College ◽  
Operative Recovery

Choledochal Cyst is a relatively rare condition. Even rarer is a choledochal cyst in association with a gallbladder carcinoma. This study reports a rare case of choledochal cyst coexisting with gallbladder carcinoma in a Bangladeshi patient. A 35 year old lady presented at IBN Sina Medical College Hospital, Kallyanpur, Dhaka with the history of recurrent right upper quadrant abdominal pain from childhood, which became severe for last 4 days before admission. The pain was colicky in nature and radiated to the back. Episodes were associated with low-grade fever, anorexia as well as vomiting. The preoperative diagnosis was made by abdominal ultrasound and MRCP. Exploratory laparotomy, enbloc cholecystectomy with excision of the choledochal cyst and roux-en-Y hepaticojejunostomy was also done. Post operative recovery was uneventful. Patient was followed up for six months and no obvious complication was noticed. Early suspicion of this rare pancreato-billiary disease is important because surgical treatment is the only way to avoid the complications of the disease.Bangladesh Journal of Medical Science Vol.16(4) 2017 p.602-605

scholarly journals Bilateral ovarian dysgerminoma with metastasis in female dog's mesenteric lymph node: a case report

2021 ◽  
Vol 1 (2) ◽  
pp. 32-41
Author(s):  
Edgar Tavares de Assis-Neto ◽  
Daniel de Araújo Viana ◽  
Márcio César Vasconcelos Silva
Keyword(s):  
Lymph Node ◽  
Histopathological Examination ◽  
Present Report ◽  
Malignant Neoplasm ◽  
Abdominal Distension ◽  
Exploratory Laparotomy ◽  
Incisional Biopsy ◽  
Mesenteric Lymph ◽  
Chemotherapy Protocol ◽  
Ovarian Dysgerminoma

Dysgerminoma is a rare malignant neoplasm, associated with hormonal dysfunctions, which occurs in canine and feline females from middle age to elderly, without racial predisposition. In the present report, we described a case of ovarian dysgerminoma in a dog, only abdominal distension, persistent vulvar bloody discharge and apathy. The animal in question underwent exploratory laparotomy, where general neoformations were detected in the ovaries, and a lymph node with abnormal characteristics was also found. Therefore, surgery for ovariosalpingoisterectomy and puncture of a fragment of the lymph node altered for incisional biopsy was performed. The diagnosis was made through histopathological examination of the ovaries of the fragment derived from the lymph node, the result of which indicated the presence of dysgerminoma in both ovaries and in the lymph node, characterizing a metastasis. In view of this result, the chemotherapy protocol with the association of carboplatin and vinblastine was instituted, which proved to be effective and not very toxic to the animal, with no clinical sign of metastasis being identified after its use.

Leiomyoma of the renal capsule: case report and literature review

2017 ◽  
Vol 85 (1) ◽  
pp. 34-35 ◽  
Author(s):  
Alessio Filianoti ◽  
Aurelio Paganelli ◽  
PierFrancesco Bassi ◽  
Giuseppe Simone ◽  
Antonio Ranieri
Keyword(s):  
Histopathological Examination ◽  
High Sensitivity ◽  
Abdominal Ultrasound ◽  
Good Prognosis ◽  
Renal Capsule ◽  
Mesenchymal Tumors ◽  
Renal Masses ◽  
Palpable Mass ◽  
Retroperitoneal Tumors

Introduction: Mesenchymal tumors are an exceptional finding in the urinary tract and renal leiomyoma is even more rare. They are usually discovered incidentally during ultrasonography examinations or autopsy. Sometimes they are clinically symptomatic with hematuria, flank pain, or palpable mass. Till today, it is still difficult to make a diagnosis of leiomyoma using the radiological examinations. Although conventional imaging has a high sensitivity and specificity in the detection of both retroperitoneal and renal masses, the diagnosis is based on histological examination, due to the poor discrimination accuracy between different retroperitoneal tumors. Case description: We report a case of renal leiomyoma in a 47-year-old woman, who incidentally discovered a retroperitoneal mass with an abdominal ultrasound scheduled for a conventional follow-up schedule of a mammary neoplasm. Partial nephrectomy was carried out with an open flank surgical approach and the diagnosis was “leiomyoma of the renal capsule”. Four years after surgery, the patient is disease-free. Conclusions: Renal leiomyomas are rare, benign, nonmetastasizing tumors with a good prognosis after surgical treatment. At present, the differential diagnosis is still possible by histopathological examination.

Classic Hodgkin Lymphoma With Intrasinusoidal Pattern of Infiltration and Concurrent Plasma Cell Variant of Castleman Disease

2019 ◽  
Vol 152 (Supplement_1) ◽  
pp. S113-S113
Author(s):  
Sean Barrett ◽  
Katsiaryna Laziuk ◽  
Richard Hammer
Keyword(s):  
Bone Marrow ◽  
Lymph Node ◽  
Hodgkin Lymphoma ◽  
Plasma Cell ◽  
Plasma Cells ◽  
Large Cell ◽  
Castleman Disease ◽  
Neoplastic Cells ◽  
Classic Hodgkin Lymphoma ◽  
Cell Variant

Abstract The relationship between Hodgkin lymphoma and plasma cell variant of Castleman disease is uncommon but has been previously described. Most reported cases were diagnosed concurrently. However, sinusoidal involvement by Hodgkin lymphoma is very rare and morphologically can mimic anaplastic large cell lymphoma. Here we present a case of classic Hodgkin lymphoma with a sinusoidal pattern of infiltration coexisting with the plasma cell variant of Castleman disease. A 16-year-old male presented to clinic with shortness of breath and a worsening cough with yearlong duration. Medical history revealed no autoimmune disease, but there was a prolonged allergy history with chronic sinusitis. Imaging showed a right sided mediastinal mass, supraclavicular lymphadenopathy, and pleural effusion. CBC demonstrated anemia, neutrophilia, lymphopenia, and thrombocytosis. Excision of a supraclavicular lymph node revealed effaced architecture with marked plasmacytosis in the interfollicular areas and permeation of sinusoidal spaces by neoplastic cells with morphological features of classic Reed-Sternberg/Hodgkin cells; histiocytes, neutrophils, and residual follicles with regressed germinal centers were seen in the background. Immunohistochemistry revealed strong positivity for CD30 and CD15 by the neoplastic cells as well as positivity for PAX5, MUM1, and CD200 and faint membrane positivity for CD20. The neoplastic cells were negative for CD79a, CD45, EMA, ALK1, and associated T-cell markers. CD138 highlighted increased plasma cells that were negative for CD56, CD200 and polytypic for kappa and lambda. Concurrent bone marrow biopsy revealed a normocellular bone marrow with mild plasmacytosis and no evidence of involvement by lymphoma. Both lymph node and bone marrow were negative for HHV-8. Flow cytometry of the lymph node revealed no monotypic B-cell population and T cells showed predominance of CD4-positive cells with no aberrant antigen expression. The unusual morphologic pattern of classic Hodgkin lymphoma made the diagnosis challenging, and demonstration of proper immunophenotype is required for diagnosis.

scholarly journals HHV-8–encoded viral IL-6 collaborates with mouse IL-6 in the development of multicentric Castleman disease in mice

Blood ◽  
2012 ◽  
Vol 119 (22) ◽  
pp. 5173-5181 ◽  
Author(s):  
Jan Suthaus ◽  
Christiane Stuhlmann-Laeisz ◽  
Van S. Tompkins ◽  
Timothy R. Rosean ◽  
Wolfram Klapper ◽  
...  
Keyword(s):  
Plasma Cell ◽  
Herpes Virus ◽  
Kaposi Sarcoma ◽  
Castleman Disease ◽  
The Body ◽  
Cell Type ◽  
Human Herpes Virus 8 ◽  
Multicentric Castleman Disease ◽  
Plasma Cell Type ◽  
Herpès Virus

Human herpes virus 8 (HHV-8) or Kaposi sarcoma-associated herpes virus is the etiologic agent of Kaposi sarcoma, primary effusion lymphoma, and plasma cell-type multicentric Castleman disease (MCD). HHV-8 encodes a viral homolog of human IL-6, called viral IL-6 (vIL-6), which does not require the cellular IL-6 receptor for binding to the ubiquitously expressed gp130 receptor subunit and subsequent JAK-STAT signaling. Thus, in contrast to IL-6, vIL-6 can stimulate virtually all cells in the body. To elucidate the mechanism by which vIL-6 drives human diseases, we generated transgenic mice that constitutively express vIL-6 under control of the MHC class I promoter. The mice were found to exhibit vIL-6 serum levels comparable with those observed in HHV-8–infected patients, to contain elevated amounts of phosphorylated STAT3 in spleen and lymph nodes, where vIL-6 was produced, and to spontaneously develop key features of human plasma cell-type MCD, including splenomegaly, multifocal lymphadenopathy, hypergammaglobulin-emia, and plasmacytosis. Transfer of the vIL-6 transgene onto an IL-6–deficient genetic background abrogated MCD-like phenotypes, indicating that endogenous mouse IL-6 is a crucial cofactor in the natural history of the disease. Our results in mice suggest that human IL-6 plays an important role in the pathogenesis of HHV-8–associated MCD.

Urinary bladder rupture due to hemangioma in a dog – case report

2018 ◽  
Vol XXIII (132) ◽  
pp. 56-64
Author(s):  
Sayonara da Luz Ferro ◽  
Ewerton Cardoso ◽  
Fernanda Jönck ◽  
Marta Cristina Thomas Heckler ◽  
Bruna Warmlin ◽  
...  
Keyword(s):  
Histopathological Examination ◽  
Clinical Signs ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Bladder Rupture ◽  
Free Fluid ◽  
Histopathological Analysis ◽  
Small Areas ◽  
Safety Margins ◽  
Metastatic Neoplasm

Hemangioma is a benign, noninvasive and non-metastatic neoplasm originating from endothelial cells of the blood vessels. The involvement of the urinary vesicle with neoplasias occurs in less than 0.5% of dogs. The main clinical signs are hematuria, dysuria, pollakiuria, incontinence and urinary obstruction. The diagnosis is based on imaging tests and is confirmed by histopathological examination. The treatment of choice is surgical resection with safety margins. This paper reports the case of a twelve-year-old Poodle with a history of abdominal pain, which was attended at the Florianópolis Veterinary Hospital. Abdominal ultrasound showed the presence of free fluid. During exploratory laparotomy, the urinary vesicle was observed to be ruptured, presenting a thickened wall and small areas of necrosis. A sample was sent for histopathological analysis and the diagnosis was of benign vascular neoplasia compatible with hemangioma.

Intra-Abdominal Actinomycetoma in a Cat

2009 ◽  
Vol 11 (8) ◽  
pp. 701-705 ◽  
Author(s):  
Mellora J. Sharman ◽  
Clara S. Goh ◽  
Richard G. Kuipers von Lande ◽  
Jennifer L. Hodgson
Keyword(s):  
Surgical Resection ◽  
Histopathological Examination ◽  
Animal Health ◽  
Exploratory Laparotomy ◽  
Abdominal Ultrasound ◽  
Neoplastic Disease ◽  
Initial Surgery ◽  
Actinomyces Species ◽  
Pfizer Animal Health ◽  
Bacterial Leakage

A 5-year-old, female Ragdoll cat was diagnosed with an intra-abdominal mycetoma involving the ileocaecal region. Diagnosis was obtained via histopathological examination following surgical resection of the mass and an ileocolic anastomosis. The initial surgery was complicated by lymphangiectasia, chylous abdominal effusion and mild bacterial leakage from the anastomosis site. A second, exploratory laparotomy was performed to augment the anastomosis with serosal patching and omentalisation and to investigate a cystic structure observed on follow-up abdominal ultrasound. Initial amoxycillin clavulanate (Clavulox; Pfizer Animal Health) therapy was ineffective, but clindamycin (Antirobe; Pfizer Animal Health) proved successful in resolving the infection. Abdominal actinomycetoma in the cat may be an under-diagnosed condition due to its close resemblance to neoplastic disease. Standard diagnostic and therapeutic regimens are commonly ineffective in Actinomyces species infections. Surgical resection along with adjunctive, long-term, selective antimicrobial therapy is effective and prognosis is good for localised lesions.

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