scholarly journals Association between peripheral muscle strength, exercise performance, and physical activity in daily life in patients with Chronic Obstructive Pulmonary Disease

Author(s):  
Anne-Kathrin Rausch-Osthoff ◽  
Malcolm Kohler ◽  
Noriane A. Sievi ◽  
Christian F. Clarenbach ◽  
Arnoldus J.R. Van Gestel

Background: Resistance training of peripheral muscles has been recommended in order to increase muscle strength in patients with Chronic Obstructive Pulmonary Disease (COPD). However, whether peripheral muscle strength is associated with exercise performance (EP) and physical activity in daily life (PADL) in these patients needs to be investigated. The aim of this study is to evaluate whether strength of the quadriceps muscle (QS) is associated with EP and daily PADL in patients with COPD. Methods: We studied patients with COPD (GOLD A-D) and measured maximal isometric strength of the left QS. PADL was measured for 7 days with a SenseWear-Pro® accelerometer. EP was quantified by the 6-minute walk distance (6MWD), the number of stands in the Sit-to-Stand Test (STST), and the handgrip-strength. Univariate and multivariate analyses were used to examine possible associations between QS, PADL and EP. Results: In 27 patients with COPD with a mean (SD) FEV1 of 37.6 (17.6)% predicted, QS was associated with 6MWD, STST, and handgrip-strength but not with PADL. Multiple linear regression analyses showed that QS was independently associated with the 6MWD (β = 0.42, 95% CI 0.09 to 0.84, p = 0.019), STST (β = 0.50, 95% CI 0.11 to 0.86, p = 0.014) and with handgrip-strength (β = 0.45, 95% CI 0.05 to 0.84, p = 0.038). Conclusions: Peripheral muscle strength may be associated with exercise performance but not with physical activity in daily life. This may be due to the fact that EP tests evaluate patients’ true abilities while PADL accelerometers may not.


2019 ◽  
Vol 3 (Supplement_1) ◽  
pp. S264-S264
Author(s):  
Shweta Gore

Abstract Dyspnea is the primary and most disabling symptoms seen in chronic obstructive pulmonary disease (COPD). Primary pathophysiological changes such as dynamic hyperinflation have been associated with the etiology of dyspnea in chronic obstructive pulmonary disease (COPD). However, since the experience of dyspnea “derives from interactions among multiple physiological, psychosocial and environmental factors”, a single correlate to accurately predict dyspnea has not been established. The purpose of this study was to identify factors that could predict shortness of breath during stair climb (SOB-SC) in community dwelling adults with COPD. We hypothesized that physical activity and muscle strength would significantly predict SOB-SC. Individuals with COPD who participated in the National Health and Nutrition Examination Survey (NHANES) between years 1999-2002 were selected for this study. Participants were excluded if they had significant mobility limitations. Socioeconomic, demographic variables, and clinical variables including BMI, physical activity, comorbidities, muscle strength, ankle brachial index, waist circumference and inflammatory markers were extracted. Logistic regression models were plotted with SOB-SC as the categorical dependent variable after assessing for collinearity using the forced-entry method. Individuals with COPD had a significantly greater proportion of SOB-SC (χ = 134.87, p < 0.001). Larger waist circumference (p = 0.002, CI = 0.04 -0.13), presence of cardiovascular disease (p = 0.001, CI = 0.76 -2.37) and Caucasian race were found to significantly predict SOB-SC after controlling for covariates. This study reinforces the importance of screening for cardiovascular disease and lifestyle modification in this population subgroup. Future studies examining differences in COPD severity are needed.





BMJ Open ◽  
2017 ◽  
Vol 7 (8) ◽  
pp. e015731 ◽  
Author(s):  
Gonzalo Labarca ◽  
Andrea Bustamante ◽  
Gonzalo Valdivia ◽  
Rodrigo Díaz ◽  
Álvaro Huete ◽  
...  

IntroductionClinical onset of chronic obstructive pulmonary disease (COPD) is the point at which the disease is first identifiable by physicians. It is a poorly defined stage which seems to include both mild spirometric and non-spirometric disease, and could be described as early grade COPD, for practical purposes. While dyspnoea; chronic bronchitis and CT imaging evidence of emphysema and airway disease may be present very early, the lone significance of dyspnoea, the most relevant symptom in COPD in identifying these individuals, has been scarcely assessed.The Searching Clinical COPD Onset (SOON) Study was designed primarily to detect clinical, physiological and structural differences between dyspnoeic and non-dyspnoeic individuals with early grade COPD. It is hypothesised that presence of dyspnoea in early disease may identify a subtype of individuals with reduced exercise capacity, notwithstanding of their spirometry results. In addition, dyspnoeic individuals will share worse quality of life, lower physical activity, greater lung hyperinflation greater emphysema and airway thickness and reduced peripheral muscle mass than their non-dyspnoeic counterpart.Methods and analysisSOON is a monocentric study, with a cross sectional design aimed at obtaining representative samples of current or ex-smoker-adults aged ≥45 and ≤80 years. Two hundred and forty participants will be enrolled into four strata, according to normal spirometry or mild spirometric obstruction and presence or not of dyspnoea modified Medical Research Council score ≥1. The primary outcome will be the difference between dyspnoeic and non-dyspnoeic individuals on the 6-min walk test performance, regardless of their spirometry results. To account for the confounding effect of heart failure on dyspnoea, stress echocardiography will be also performed. Secondary outcomes will include clinical (quality of life, physical activity), physiological (exercise testing) and structural characteristics (emphysema, airway disease and peripheral muscle mass by CT imaging).Ethics and disseminationThe Institutional Ethics Committee from Pontificia Universidad Católica de Chile has approved the study protocol and signed informed consent will be obtained from all participants. The findings of the trial will be disseminated through relevant peer-reviewed journals and international conference presentations.Trial registration numberNCT03026439.



2021 ◽  
Vol 9 ◽  
pp. 205031212110647
Author(s):  
Shojiro Egoshi ◽  
Jun Horie ◽  
Akinori Nakagawa ◽  
Yuriko Matsunaga ◽  
Shinichiro Hayashi

Objectives: Research on the determinants of physical activity in mildly symptomatic patients with chronic obstructive pulmonary disease is lacking. This study examined the predictors of physical activity in patients with low-risk chronic obstructive pulmonary disease. Methods: A total of 41 male patients with chronic obstructive pulmonary disease belonging to Group A of the Global Initiative for Chronic Obstructive Lung Disease were included. Regarding the objective index, the physical activity (number of steps/day and the amount of Ex (metabolic equivalent × hours)/day) of the participants was measured with a tri-axis accelerometer. In addition, regarding the evaluation index, respiratory function and dynamic lung hyperinflation were measured by a spirometer, skeletal muscle mass was measured using bioelectrical impedance analysis, skeletal muscle strength (grip and lower limb muscle strength) was measured using a dynamometer, exercise capacity was measured by the incremental shuttle walking test, and health-related quality of life was measured. Results: Significant correlations were found between the number of steps per day and age (ρ = −0.501, p < 0.01), forced vital capacity predictive values (ρ = 0.381, p < 0.05), dynamic lung hyperinflation (ρ = 0.454, p < 0.01), grip strength (ρ = 0.318, p < 0.05), and walking distance in incremental shuttle walking test (ρ = 0.779, p < 0.01), but not skeletal muscle mass, lower limb muscle strength, or health-related quality of life. A multiple-regression analysis with the number of steps per day as the dependent variable extracted only walking distance in incremental shuttle walking test, yielding a moderate single-regression equation (steps/day = −934.909 + 11.052 × walking distance in incremental shuttle walking test, adjusted R2 = 0.548, p < 0.001). Conclusion: It was suggested that the amount of physical activity of patients with low-risk chronic obstructive pulmonary disease could be predicted by walking distance in incremental shuttle walking test.





2011 ◽  
Vol 31 (1) ◽  
pp. 11-24 ◽  
Author(s):  
Priscila Games Robles ◽  
Sunita Mathur ◽  
Tania Janaudis-Fereira ◽  
Thomas E. Dolmage ◽  
Roger S. Goldstein ◽  
...  




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