scholarly journals Diagnostic utility of serum melatonin levels in systemic lupus erythematosus: a case-control study

Reumatismo ◽  
2017 ◽  
Vol 69 (4) ◽  
pp. 170 ◽  
Author(s):  
A.B. Rasheed ◽  
M.S. Daoud ◽  
F.I. Gorial
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Predictive Value ◽  
Case Control Study ◽  
Case Control ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Melatonin Concentration ◽  
Baseline Characteristics ◽  
Control Study

Systemic lupus erythematosus (SLE) is a chronic systemic autoimmune inflammatory disease and early diagnosis is of clinical and therapeutic importance. Melatonin is an endogenous endolamine hormone that plays an important role in the immune system due to its anti-inflammatory action. This study was designed to assess serum melatonin levels in SLE patients and to evaluate the possible correlation between serum melatonin and patients’ baseline characteristics. A case-control study was performed on 50 SLE patients (48 females and 2 males), diagnosed according to the revised 1997 ACR Criteria, and 25 healthy controls (24 females and 1 male), matched by age and sex. Daily serum melatonin levels were investigated in all participants using human melatonin enzyme linked immunosorbent assay (ELISA) kit (MYBIOSOURCE (MBS), United States). Serum melatonin concentration was significantly lower in patients with SLE compared to healthy controls (19.17±6.86 pg/mL vs 23.26±6.71 pg/mL, p=0.017). Serum melatonin concentration ≤18.51 pg/mL was the optimum cut off value to differentiate between SLE patients and healthy controls with an accuracy of 69.3%, a sensitivity of 66%, and a specificity of 76%. The positive predictive value (PPV) at pretest 50% was 73.3% and PPV at pretest 90% was 96.1%; the negative predictive value (NPV) at 10% was 95.3%. Patients’ characteristics were not significantly correlated with serum melatonin concentrations using multiple logistic regression analysis. Serum melatonin was a valid measure to differentiate between SLE patients and healthy controls with good accuracy, sensitivity and specificity and PPV and NPV. There was no significant correlation between serum melatonin concentrations and patients’ baseline characteristics.

scholarly journals Measurement of serum interferon alpha in Egyptian patients with systemic lupus erythematosus and evaluation of its effect on disease activity: a case-control study

Reumatismo ◽  
2020 ◽  
Vol 72 (3) ◽  
pp. 145-153
Author(s):  
A. Fayed ◽  
M.M. El Menyawi ◽  
M. Ghanema ◽  
O. Shaker ◽  
R. Elgohary
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Disease Activity ◽  
Interferon Alpha ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Complement C3 ◽  
Healthy Controls ◽  
Systemic Lupus ◽  
Control Study

Much evidence highlighted the role of interferon alpha (IFN-α) in systemic lupus erythematosus (SLE) and suggested its possible role in assessing disease activity. We measured serum IFN-α in Egyptian SLE patients in order to determine a cutoff value that can be used to distinguish patients from healthy controls and explored its clinical value in monitoring disease activity and different aspects of the disease, in particular lupus nephritis. This cross-sectional, case-control study was conducted on 59 SLE patients and 30 healthy controls. Serum IFN-α was measured in all participants using sensitive enzyme-linked immunosorbent assay (ELISA). SLE patients underwent assessment of disease activity using the SLE disease activity index-2000 (SLEDAI-2K) as well as an evaluation of proteinuria, complement C3 and C4, and serology. Patients with evidence of renal involvement underwent renal biopsy. The median serum IFN-α was 81.8 pg/mL (interquartile range [IQR] 63.4:102.4), which was significantly higher than in healthy controls (median 10.3 pg/mL [IQR 7.3:11.6]) (p<0.001). At serum level of 14.7 pg/mL, IFN-α has high sensitivity and specificity to discriminate SLE patients from controls, with high positive and negative predictive values. Serum IFN-α was not associated with markers of disease activity, clinical features and anti-double stranded DNA. Furthermore, it was not associated with markers of renal activity, including proteinuria, C3 and C4 complement factors and histopathology renal classes. Despite elevated levels of serum IFN-α in SLE patients, it is not possible to use it as a biomarker for disease activity.

scholarly journals Anthrax Vaccine and the Risk of Rheumatoid Arthritis and Systemic Lupus Erythematosus in the U.S. Military: A Case–Control Study

2016 ◽  
Vol 181 (10) ◽  
pp. 1348-1356 ◽  
Author(s):  
Barbara H. Bardenheier ◽  
Jonathan Duffy ◽  
Susan K. Duderstadt ◽  
Jay B. Higgs ◽  
Michael P. Keith ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Lupus ◽  
Anthrax Vaccine ◽  
Control Study ◽  
The U.S

scholarly journals Clinically diagnosed urticaria and risk of systemic lupus erythematosus in children: A nationwide population-based case-control study

2018 ◽  
Vol 29 (7) ◽  
pp. 732-739 ◽  
Author(s):  
Chien-Hung Lin ◽  
Peir-Haur Hung ◽  
Hsiao-Yun Hu ◽  
Chi-Jung Chung ◽  
Tsung-Hsien Chen ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Population Based ◽  
Case Control ◽  
Systemic Lupus ◽  
Control Study

A case-control study of oral diseases and quality of life in individuals with rheumatoid arthritis and systemic lupus erythematosus

2020 ◽  
Author(s):  
Brena Rodrigues Manzano ◽  
Paulo Sérgio da Silva Santos ◽  
Matheus Henrique Bariquelo ◽  
Nathália Rodrigues Germano Merlini ◽  
Heitor Marques Honório ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Rheumatoid Arthritis ◽  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Oral Diseases ◽  
Systemic Lupus ◽  
Control Study

Chronic or recurrent headache in patients with systemic lupus erythematosus: a case control study

Lupus ◽  
1999 ◽  
Vol 8 (2) ◽  
pp. 151-157 ◽  
Author(s):  
A Fernández-Nebro ◽  
R Palacios-Muñoz ◽  
J Gordillo ◽  
M Abarca-Costalago ◽  
M De Haro-Liger ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Case Control ◽  
Systemic Lupus ◽  
Recurrent Headache ◽  
Control Study

scholarly journals Childhood-Onset Systemic Lupus Erythematosus: How Is It Associated with Breastfeeding and Mode of Delivery?

2020 ◽  
Vol 10 (01) ◽  
pp. e12-e15
Author(s):  
Banafsheh Sadeghi ◽  
Elham Rayzan ◽  
Fatemeh Tahghighi ◽  
Mamak Shariat ◽  
Fatemeh Nayeri ◽  
...  
Keyword(s):  
Systemic Lupus Erythematosus ◽  
Lupus Erythematosus ◽  
Case Control Study ◽  
Disease Incidence ◽  
Mode Of Delivery ◽  
Case Control ◽  
Control Group ◽  
Systemic Lupus ◽  
Section Method ◽  
Control Study

AbstractBreast milk is a rich source of infants' nutrition and also known to be a source of immune-enhancing molecules. The perinatal factors might have long-term effects on the immune system and also, breastfeeding may have an important role. Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease that leads to various organ damages. This idiopathic disease is characterized by high levels of autoantibodies in the circulation. In this case–control study, we have evaluated the association between the breastfeeding and mode of delivery and SLE incidence. In this case–control study, SLE cases were identified in Children's Medical Center and Imam Khomeini Hospital Complex between 2011 and 2017. The control group was chosen from the schools of Tehran and Sari cities. The questionnaires were completed by one of the parents. Seventy-nine cases and 301 controls were included. There was no association among breastfeeding, duration of breastfeeding or exclusive breastfeeding and SLE, the age of diagnosis, or its major organ involvements (p > 0.05). The cesarean section (C-section) method was significantly associated with higher disease incidence (p < 0.005). The feeding method during infancy had no significant impact on SLE incidence and onset, while the C-section method increased the incident rate.

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