scholarly journals Lateral Ankle Sprain and Subsequent Ankle Sprain Risk: A Systematic Review

2021 ◽  
Vol 56 (6) ◽  
pp. 578-585
Author(s):  
Erik A. Wikstrom ◽  
Mary Spencer Cain ◽  
Avinash Chandran ◽  
Kyeongtak Song ◽  
Tasha Regan ◽  
...  
Keyword(s):  
Ankle Sprain ◽  
Data Extraction ◽  
Design Parameters ◽  
Data Synthesis ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Assessment Scores ◽  
Study Selection ◽  
History Of

Objective To evaluate the evidence regarding the association between lateral ankle sprain (LAS) history and the subsequent LAS risk, as well as sex differences in the observed associations. Data Sources PubMed, CINAHL, and SPORTDiscus were searched through July 2020 for articles on LAS history and incidence during the study period. Study Selection Studies were included if they were prospective in nature and the authors reported the number of participants with and those without a history of LAS at study initiation as well as the number of participants in each group who sustained an LAS during the investigation. Data Extraction Data were study design parameters as well as the number of participants with and those without an LAS history and the number of subsequent LASs that occurred in both groups. Risk ratios (RRs) with 95% CIs compared the risk of LAS during the study period between those with and those without an LAS history for each investigation. Data Synthesis A total of 19 studies involving 6567 patients were included. The follow-up periods ranged from 14 weeks to 2 years. Assessment scores indicated the studies were of moderate to high quality. A significantly higher risk of LAS during the study period was observed among those with a history of LAS in 10 of 15 studies (RR range = 1.29–6.06). Similar associations were seen in 4 of 6 studies of all-male samples (RR range = 1.38–8.65) and 1 of 4 studies with an all-female sample (RR = 4.28). Conclusions Strong evidence indicates that a previous LAS increased the risk of a subsequent LAS injury. Men with a history of LAS appeared to be at a higher risk of sustaining a subsequent LAS, but women were not. However, further data are needed to draw definitive conclusions from the limited number of sex-specific studies.

Lateral ankle sprain increases subsequent ankle sprain risk: a systematic review

2020 ◽  
Author(s):  
Erik A Wikstrom ◽  
M Spencer Cain ◽  
Avinash Chandran ◽  
Kyeongtak Song ◽  
Tasha Regan ◽  
...  
Keyword(s):  
Ankle Sprain ◽  
Data Extraction ◽  
Included Study ◽  
Design Parameters ◽  
Injury Incidence ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Assessment Scores ◽  
Study Selection ◽  
History Of

Abstract Objective: To evaluate the evidence surrounding the association between lateral ankle sprain (LAS) history and subsequent LAS risk, as well as sex-differences in the observed associations. Data Sources: PubMed, CINAHL, and SPORTDiscus were searched through July 2020 for articles reporting LAS injury history and injury incidence during a study period. Study Selection: Studies were included if they were prospective in nature, reported the number of participants with and without a history of LAS at study initiation, and reported the number of participants from each group that sustained a LAS during the study period. Data Extraction: Data included study design parameters as well as the number of participants with and without a LAS history, and the number of subsequent LAS that occurred to both groups. Risk ratios (RR) with 95% confidence intervals (CI) compared the risk of LAS within the study period between those with and without a LAS history for each included investigation. Data Synthesis: Nineteen studies with a total of 6,567 patients were included. Follow-up periods ranged from 14 weeks to 2 years. Quality assessment scores indicate moderate to high quality studies were included. A significantly higher risk of LAS within the study period was observed among those with a history of LAS in 10 out of 15 studies (RR range=1.29–6.06). Similar associations were seen in four out of six studies that included an all-male sample (RR Range=1.38–8.65), and one out of four studies with an all-female sample (RR=4.28). Conclusion: There is strong evidence to support that a previous LAS increases the risk of a subsequent LAS injury. Males but not females with a history of a LAS appear to be at a higher risk of sustaining a subsequent LAS but further data are needed to draw definitive conclusions based on the limited number of sex specific studies.

Muscle Strength Deficit though Intact Proprioception after Lateral Ankle Sprain without Persistent Instability

2021 ◽  
Author(s):  
Adel M. Madkhali ◽  
Shibili Nuhmani
Keyword(s):  
Ankle Sprain ◽  
Peak Torque ◽  
Position Sense ◽  
Joint Position Sense ◽  
Joint Position ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Cohen’S D ◽  
History Of ◽  
Cohen's D

Abstract Background Lateral ankle sprain is one of the most common injuries in competitive sports. Previous studies which investigated muscle strength and proprioception (joint position sense) focused on subjects who sustained ankle sprain with instability. It is also important to investigate strength deficits and proprioception in subjects with a history of ankle sprain without instability. Therefore the aim of the study is to investigate proprioception and muscle strength deficits in athletes with lateral ankle sprain. Methods Twenty-four male athletes with a history of lateral ankle sprain and 24 age-matched controls (mean age of 22.42±4.13 years, mean height of 173±5.73 cm, and mean weight of 71.20±7.55 Kg) participated in this cross-sectional study. Peak torque and peak torque ratio at speeds of 30 and 120°/s for concentric and eccentric ankle inversion/eversion were evaluated using an isokinetic dynamometer. The joint position sense of the ankle joint was evaluated using an active angle reproduction test. Result Peak torque produced was significantly less in subjects with history of ankle sprain in concentric inversion 30°/s(t(47)=4.11; p=0.000, Cohen’s d=1.29), concentric inversion 120°/s (t(47)=3.01; p=0.006, Cohen’s d=1.13), concentric eversion 30°/s (t(47)=3.85; p=0.001, Cohen’s d=1.24) and concentric eversion 120°/s (t(47)=3.15; p=0.005, Cohen’s d=1.09). At the same time there was no significant difference observed in eccentric eversion peak torque in both speed (eccentric eversion 30°/s p=0.079; eccentric eversion 120°/s p=0.867) between experimental and control group. No significant difference was found in the joint position sense in the maximal active inversion −5° position (p=0.312) and the 15° inversion position (P=0.386) between both group. Conclusion The study’s results reported a significantly less peak torque of invertors and evertors during concentric movements in athletes with history of ankle sprain. At the same time, no significant difference reported in the evertor/invertor peak torque ratio, and active joint position sense between the 2 groups.

Lactulose in the Management of Constipation: A Current Review

1992 ◽  
Vol 26 (10) ◽  
pp. 1277-1282 ◽  
Author(s):  
Theresa V. Kot ◽  
Ngaire A. Pettit-Young
Keyword(s):  
Clinical Trials ◽  
Adverse Effects ◽  
Clinical Studies ◽  
Data Extraction ◽  
Point Of View ◽  
Data Synthesis ◽  
Study Selection ◽  
Beneficial Response ◽  
A Current

OBJECTIVE: To review the current published clinical studies evaluating the clinical efficacy and safety of lactulose compared with other laxatives or placebo. Adverse effects associated with lactulose are also reported. DATA SOURCES: Information was retrieved by searching the MEDLINE and EMBASE databases for clinical trials, abstracts, conference proceedings, and review articles dealing with lactulose. STUDY SELECTION: Emphasis was placed on clinical trials where lactulose was compared with other laxatives or placebo in patient populations where the diagnosis of constipation was reasonably established. DATA EXTRACTION: The methodology and results from clinical studies were evaluated. Assessment of the studies was made based on diagnosis of constipation, prior management of patients, follow-up of patients, dosage, and adverse effects. DATA SYNTHESIS: Clinical trials in geriatric patients, terminally ill patients, children, and normal and constipated subjects were reviewed. In most instances, lactulose was compared with a placebo, without incorporating the current education on dietary techniques for improving defecation. CONCLUSIONS: Generally, clinical trials have demonstrated a beneficial response compared with placebo, although sometimes that response has been only marginally better, from a clinical point of view.

Effects of Inversion Perturbation After Step-Down on the Latency of the Peroneus Longus and Peroneus Brevis

2011 ◽  
Vol 27 (4) ◽  
pp. 283-290 ◽  
Author(s):  
Adam C. Knight ◽  
Wendi H. Weimar
Keyword(s):  
Ankle Sprain ◽  
Ankle Sprains ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Peroneus Longus ◽  
Significant Difference ◽  
History Of ◽  
Step Down ◽  
Peroneus Brevis ◽  
High Ankle Sprain

The purpose of this investigation was to determine the effect of different types of ankle sprains on the response latency of the peroneus longus and peroneus brevis to an inversion perturbation, as well as the time to complete the perturbation (time to maximum inversion). To create a forced inversion moment of the ankle, an outer sole with fulcrum was used to cause 25 degrees of inversion at the ankle upon landing from a 27 cm step-down task. Forty participants completed the study: 15 participants had no history of any ankle sprain, 15 participants had a history of a lateral ankle sprain, and 10 participants had a history of a high ankle sprain. There was not a significant difference between the injury groups for the latency measurements or the time to maximum inversion. These findings indicate that a previous lateral ankle sprain or high ankle sprain does not affect the latency of the peroneal muscles or the time to complete the inversion range of motion.

Clinical and radiological predictors for persistent complaints five years after a lateral ankle sprain: A long-term follow-up study in primary care

2018 ◽  
Vol 21 (3) ◽  
pp. 250-256 ◽  
Author(s):  
Adinda K.E. Mailuhu ◽  
Edwin H.G. Oei ◽  
Nienke van Putte-Katier ◽  
John M. van Ochten ◽  
Patrick J.E. Bindels ◽  
...  
Keyword(s):  
Primary Care ◽  
Ankle Sprain ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Follow Up Study ◽  
Long Term Follow Up

scholarly journals The Effect of Ankle Bracing on Kinematics in Simulated Sprain and Drop Landings: A Double-Blind, Placebo-Controlled Study

2019 ◽  
Vol 47 (6) ◽  
pp. 1480-1487
Author(s):  
Alison N. Agres ◽  
Marios Chrysanthou ◽  
Peter C. Raffalt
Keyword(s):  
Ankle Sprain ◽  
Sagittal Plane ◽  
Ankle Instability ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Ankle Inversion ◽  
Ankle Kinematics ◽  
Ankle Brace ◽  
History Of ◽  
Drop Landings

Background: The efficacy of external ankle braces to protect against sudden inversion sprain has yet to be determined while taking into account the possible placebo effect of brace application. Purpose: To assess the protective effect of an external ankle brace on ankle kinematics during simulated inversion sprain and single-legged drop landings among individuals with a history of unilateral lateral ankle sprain. Hypothesis: The primary hypothesis was that active and placebo external braces would reduce inversion angle during simulated inversion sprain. Study Design: Controlled laboratory study. Methods: Sixteen participants with ankle instability and previous sprain performed single-legged drop landings and sudden inversion tilt perturbations. Kinematics of the affected limb were assessed in 3 conditions (active bracing, passive placebo bracing, and unbraced) across 2 measurement days. Participators and investigators were blinded to the brace type tested. The effect of bracing on kinematics was assessed with repeated measures analysis of variance with statistical parametric mapping, with post hoc tests performed for significant interactions. Results: Only active bracing reduced inversion angles during a sudden ankle inversion when compared with the unbraced condition. This reduction was apparent between 65 and 140 milliseconds after the initial fall. No significant differences in inversion angle were found between the passive placebo brace and unbraced conditions during sudden ankle inversion. Furthermore, no significant differences were found among all tested conditions in the sagittal plane kinematics at the knee and ankle. Conclusion: During an inversion sprain, only the actively protecting ankle brace limited inversion angles among participants. These results do not indicate a placebo effect of external bracing for patients with ankle instability and a history of unilateral ankle sprain. Furthermore, sagittal plane knee kinematics appear to remain unaffected by bracing during single-legged landing, owing to the limited effects of bracing on sagittal ankle kinematics. These results highlight the role of brace design on biomechanical function during sports-related and injury-prone movements. Clinical Relevance: Athletes prone to reinjury after lateral ankle sprain may benefit from brace designs that allow for full sagittal range of motion but restrict only frontal plane motion.

FDA Policy on Unapproved Drug Products: Past, Present, and Future

2005 ◽  
Vol 39 (7-8) ◽  
pp. 1260-1264 ◽  
Author(s):  
Renu Chhabra ◽  
Mary E Kremzner ◽  
Brenda J Kiliany
Keyword(s):  
Data Extraction ◽  
Drug Regulation ◽  
Data Sources ◽  
Federal Regulations ◽  
Data Synthesis ◽  
Safety And Efficacy ◽  
Drug Products ◽  
The Past ◽  
Study Selection ◽  
History Of

OBJECTIVE To review the history of drug regulation by the Food and Drug Administration (FDA) as it relates to unapproved drugs and FDA policy, along with the FDA's efforts to avoid future incidents by amending and enforcing those policies that are already in place. DATA SOURCES Data from FDA history documents, FDA guidances, Code of Federal Regulations Title 21, and presentations by the FDA's Office of Compliance were gathered. STUDY SELECTION AND DATA EXTRACTION All information identified from the data sources was evaluated, and all information deemed relevant was included for this review. DATA SYNTHESIS Contrary to popular belief, there are drugs on the market that have not been evaluated for safety or efficacy by the FDA. For almost a century, the FDA has taken action against public health threats posed by unapproved drug products, and today's drugs and vaccines are required to demonstrate both safety and efficacy prior to marketing. The FDA has taken great strides to ensure the welfare of Americans by reacting to disasters that have occurred in the past and being proactive by setting regulations that will prevent such catastrophes from occurring in the future. CONCLUSIONS The FDA recognizes that drug regulation is an ongoing process and that, although we have come a long way, there is still much to be done.

scholarly journals Joint Stability Characteristics of the Ankle Complex in Female Athletes With Histories of Lateral Ankle Sprain, Part II: Clinical Experience Using Arthrometric Measurement

2014 ◽  
Vol 49 (2) ◽  
pp. 198-203 ◽  
Author(s):  
John E. Kovaleski ◽  
Robert J. Heitman ◽  
Larry R. Gurchiek ◽  
J. M. Hollis ◽  
Wei Liu ◽  
...  
Keyword(s):  
Ankle Sprain ◽  
Soft Tissues ◽  
Complex Motion ◽  
Lateral Ankle Sprain ◽  
Lateral Ankle ◽  
Anterior Displacement ◽  
History Of ◽  
Ankle Complex ◽  
And Inversion ◽  
Lateral Ankle Ligaments

Context: This is part II of a 2-part series discussing stability characteristics of the ankle complex. In part I, we used a cadaver model to examine the effects of sectioning the lateral ankle ligaments on anterior and inversion motion and stiffness of the ankle complex. In part II, we wanted to build on and apply these findings to the clinical assessment of ankle-complex motion and stiffness in a group of athletes with a history of unilateral ankle sprain. Objective: To examine ankle-complex motion and stiffness in a group of athletes with reported history of lateral ankle sprain. Design: Cross-sectional study. Setting: University research laboratory. Patients or Other Participants: Twenty-five female college athletes (age = 19.4 ± 1.4 years, height = 170.2 ± 7.4 cm, mass = 67.3 ± 10.0 kg) with histories of unilateral ankle sprain. Intervention(s): All ankles underwent loading with an ankle arthrometer. Ankles were tested bilaterally. Main Outcome Measure(s): The dependent variables were anterior displacement, anterior end-range stiffness, inversion rotation, and inversion end-range stiffness. Results: Anterior displacement of the ankle complex did not differ between the uninjured and sprained ankles (P = .37), whereas ankle-complex rotation was greater for the sprained ankles (P = .03). The sprained ankles had less anterior and inversion end-range stiffness than the uninjured ankles (P < .01). Conclusions: Changes in ankle-complex laxity and end-range stiffness were detected in ankles with histories of sprain. These results indicate the presence of altered mechanical characteristics in the soft tissues of the sprained ankles.

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