A Negative Pressure Method Using a CVP Manometer for the Ascertainment of the Epidural Space

1989 ◽  
Vol 22 (6) ◽  
pp. 922
Author(s):  
Jae Kyu Cheun ◽  
Dae Lim Jee
Keyword(s):  
Epidural Space ◽  
Negative Pressure ◽  
Pressure Method

Search for algorithms for treatment of non-specific septic spondylodiscitis

2020 ◽  
pp. 65-72
Author(s):  
V. N. Obolensky ◽  
A. V. Sytnik
Keyword(s):  
Antibiotic Therapy ◽  
Negative Pressure ◽  
Spinal Column ◽  
Treatment Results ◽  
Pressure Method ◽  
Personalized Approach ◽  
Staged Treatment ◽  
Local Antibiotic ◽  
Local Antibiotic Therapy

The treatment results of 30 patients with non-specific purulent diseases of the spine were analyzed using various methods — primary or secondary stabilization of the spinal column, local negative pressure method, prolonged local antibiotic therapy method and various implants. The results were rated as «excellent» in 16 patients, «good» in 7 people, «satisfactory» in 4 cases (relapses) and 3 patients died. The results obtained indicate the need for a personalized approach to treatment tactics, the feasibility of staged treatment and the use of additional methods.

scholarly journals Method for Pulmonary Administration Using Negative Pressure Generated by Inspiration in Mice

Pharmaceutics ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 200 ◽  
Author(s):  
Yuki Oiso ◽  
Tomomi Akita ◽  
Daiki Kato ◽  
Chikamasa Yamashita
Keyword(s):  
Lung Injury ◽  
Negative Pressure ◽  
Drug Distribution ◽  
Pulmonary Delivery ◽  
Chronic Obstructive ◽  
Clinical Tests ◽  
Obstructive Pulmonary Disease ◽  
Pulmonary Administration ◽  
Pressure Method ◽  
All Trans Retinoic Acid

When developing inhaled medicines for respiratory diseases, such as chronic obstructive pulmonary disease, drugs need to be administered by pulmonary delivery to animals in non-clinical tests. Common methods require application of pressure during administration, and it may cause lung injury, so we focused on the inhalation of liquid medicines by mice themselves. This study aimed to evaluate a negative pressure method of pulmonary administration in mice by self-inhalation. First, to confirm the accuracy of delivery of liquid medicines into lungs and the potential for lung injury, Institute of Cancer Research (ICR) mice received methylene blue tetrahydrate or saline by the negative pressure method. We assessed drug distribution and usefulness of this method by administering porcine pancreatic elastase and all-trans-retinoic acid (ATRA) to mice. Consequently, we confirmed good distribution of the dye and no injury such as disruption of blood flow or destruction of alveoli in lungs of mice. Following production of the murine emphysema model, the mean linear intercept (Lm) was calculated as 78 ± 4 μm. Moreover, a significant therapeutic effect of administration of the ATRA was confirmed. These results suggest that this negative pressure method of administration may be useful for pulmonary administration in non-clinical tests.

scholarly journals Feasibility of Using the Epidural Space Detecting Device (EPI-DetectionTM) for Interlaminar Cervical Epidural Injection

2020 ◽  
Vol 9 (8) ◽  
pp. 2355
Author(s):  
Jiin Kang ◽  
Sam Sun Park ◽  
Chul Hwan Kim ◽  
Eui Chul Kim ◽  
Hyung Cheol Kim ◽  
...  
Keyword(s):  
Radiation Dose ◽  
Radiation Exposure ◽  
Epidural Space ◽  
Negative Pressure ◽  
Operation Time ◽  
Epidural Injection ◽  
Cervical Radiculopathy ◽  
Loss Of Resistance ◽  
Operative Complications ◽  
Post Operative Complications

Cervical epidural injection (CEI), which is widely used for the treatment of cervical radiculopathy, sometimes has been associated with post-operative complications. Recently, EPI-DetectionTM, which detects the negative pressure of the epidural space and notifies the proceduralist by flashing a light and producing a beeping sound, was introduced. We assumed that the newly developed device could be as safe and efficient as the conventional loss of resistance (LOR) method. Therefore, we aimed to evaluate the effectiveness of the EPI-DetectionTM and compare it to that of the conventional LOR method. We randomly assigned 57 patients to the LOR and EPI-Detection groups (29 and 28 patients, respectively). Subjects were treated with interlaminar CEI (ILCEI) using one of two methods. The measured parameters, i.e., operation time and radiation dose were lower in the EPI-DetectionTM group (4.6 ± 1.2 min vs. 6.9 ± 2.1 min; and 223.2 ± 206.7 mGy·cm2 vs. 380.3 ± 340.9 mGy·cm2, respectively; all p < 0.05) than in the LOR group. There were no complications noted in either group. Both the EPI-DetectionTM and LOR methods were safe and effective in detecting the epidural space, but the former was superior to the latter in terms of operation time and radiation exposure. The EPI-DetectionTM may help perform ILCEI safely.

Enhanced needle visibility by microbubbles generated with negative pressure using an in-plane technique

2019 ◽  
Vol 44 (8) ◽  
pp. 805-808
Author(s):  
Yong Liu ◽  
Xingxing Sun ◽  
Wei Qian ◽  
Wantao Liu ◽  
Wei Mei
Keyword(s):  
Factorial Design ◽  
Negative Pressure ◽  
Second Phase ◽  
Ultrasound Images ◽  
Visibility Analysis ◽  
Pressure Method ◽  
Mixing Method ◽  
Plane Technique ◽  
Needle Visibility ◽  
Method Group

Background and objectivesOur previous work found that needle visibility could be improved by introducing microbubbles into needles. The primary aim of this study was to test the hypothesis that the negative pressure method is superior to two other methods for enhancing needle visibility by introducing microbubbles into needles. The secondary aim was to evaluate the impacts of three factors on the visibility of microbubble-filled needles.MethodsIn the first phase, three methods, including the negative pressure method, the mixing method and commercialized microbubbles, were applied to generate microbubbles inside needles for comparison of visibility in a porcine meat model. In the second phase, three factors were tested with a 2×5×5 factorial design to explore their influence on the visibility of microbubble-filled needles. The three factors included types of needles, insertion angles and types of contents inside needles. Needles filled with saline without microbubbles were used as the control in both phases. Insertion videos were recorded, and ultrasound images of needles were captured for the objective visibility analysis.ResultsNeedle visibility was highest in the negative pressure method group (p<0.001). Needle visibility was mainly determined by insertion angles (p<0.001). Microbubble-filled needles were more visible than control needles at 40°, 50° and 60° (p<0.001, p<0.001 and p<0.001, respectively).ConclusionsNeedle visibility can be significantly improved by microbubbles generated with the negative pressure method when insertion angles are 40°, 50° and 60° in porcine meat.

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