A review of the use of Streptozotocin (STZ) in the  induction of diabetes in rats and subsequent ocular  tissue changes

Ocular graft-versus-host disease (GVHD) is one of the most frequent and long-term complications affecting patients after haematopoietic stem cell transplantation. It is associated with significant morbidity and a marked reduction in quality of life. Although common, currently there are no widely accepted guidelines available for its management, and no suggested regime of treatment that is completely satisfactory. So far, prophylactic treatment strategies for ocular GVHD have yet to be developed and treatment is normally initiated based on symptoms often after permanent ocular tissue changes and surface damage has occurred. Here we describe a case of recurrent ocular GVHD and its associated complications that was highly refractory to treatment.

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Cerebral Tissue Response in Chronic Electrode Implantation

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100080547 ◽

1977 ◽

Vol 35 ◽

pp. 624-625

Author(s):

R.F. Dodson ◽

L.W-F Chu ◽

N. Ishihara

Keyword(s):

Tissue Response ◽

Whole Body ◽

Platinum Electrodes ◽

Fixed Tissue ◽

Electrode Implantation ◽

Surface Areas ◽

Tissue Changes ◽

Micron Diameter ◽

Extent Of Damage ◽

Electrode Sheath

The extent of damage surrounding an implanted electrode in the cerebral cortex is a question of significant importance with regard to attaining consistency and validity of physiological recordings. In order to determine the extent of such tissue changes, 150 micron diameter platinum electrodes were implanted in the cortex of four adult baboons, and after eight days the animals were sacrificed by whole body perfusion with a 3% glutaraldehyde in 0.1M phosphate fixative.The calvarium was carefully removed and the electrode tracts were readily discernible in the firm, glutaraldehyde fixed tissue.Careful dissection of the zone of the electrode tract resulted in a small block which was further sectioned into tip, mid-tract and surface areas. Ultrastructurally, damage extended from the electrode sheath to the greatest extent of from 0.2 to 3.5 mm.

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XRF and PIXE Analysis of light and Dark Adapted Ocular Tissue

Proceedings, annual meeting, Electron Microscopy Society of America ◽

10.1017/s0424820100053619 ◽

1982 ◽

Vol 40 ◽

pp. 190-191

Author(s):

B. J. Panessa ◽

H. W. Kraner ◽

J. B. Warren ◽

K. W. Jones

Keyword(s):

Trace Metals ◽

Pigment Epithelium ◽

Nerve Impulse ◽

Light Response ◽

Ocular Tissue ◽

Emission Spectrometry ◽

Retinol Dehydrogenase ◽

Pixe Analysis ◽

X Ray ◽

Optimal Function

During photoexcitation the retina requires specific electrolytes and trace metals for optimal function (Na, Mg, Cl, K, Ca, S, P, Cu and Zn). According to Hagins (1981), photoexcitation and generation of a nerve impulse involves the movement of Ca from the rhodopsin-ladened membranes of the rod outer segment (ROS) to the plasmalemma, which in turn decreases the in-flow of Na into the photoreceptor, resulting in hyperpolarization. In toad isolated retinas, the presence of Ba has been found to increase the amplitude and prolong the delay of the light response (Brown and Flaming, 1978). Trace metals such as Cu, Zn and Se are essential for the activity of the metalloenzymes of the retina and retina pigment epithelium (RPE) (i.e. carbonic anhydrase, retinol dehydrogenase, tyrosinase, glutathione peroxidase, superoxide dismutase...). Therefore the content and fluctuations of these elements in the retina and choroid are of fundamental importance for the maintenance of vision. This paper presents elemental data from light and dark adapted frog ocular tissues examined by electron beam induced x-ray microanalysis, x-ray fluorescence spectrometry (XRF) and proton induced x-ray emission spectrometry (PIXE).

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Serum Enzyme, Corticosterone and Tissue Changes in Rats Following a Single Oral Dose of Ethanol

Quarterly Journal of Studies on Alcohol ◽

10.15288/qjsa.1970.31.281 ◽

1970 ◽

Vol 31 (2) ◽

pp. 281-287 ◽

Cited By ~ 2

Author(s):

Paul D. Altland ◽

Benjamin Highman ◽

Milton G. Parker ◽

Michael P. Dieter

Keyword(s):

Oral Dose ◽

Single Oral Dose ◽

Serum Enzyme ◽

Tissue Changes

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AN UNUSUAL CASE OF EXOPHTHALMOS WITH GENERAL CONNECTIVE TISSUE CHANGES

Acta Endocrinologica ◽

10.1530/acta.0.xxxiii0613 ◽

1960 ◽

Vol XXXIII (IV) ◽

pp. 613-622 ◽

Cited By ~ 2

Author(s):

B.-A. Lamberg ◽

O. Wegelius ◽

B. Kuhlbäck ◽

C. Olin-Lamberg

Keyword(s):

Renal Failure ◽

Connective Tissue ◽

Beneficial Effect ◽

Muscle Tissue ◽

Clinical Picture ◽

Unusual Case ◽

Systemic Treatment ◽

Nasal Epithelium ◽

Tissue Changes ◽

Histochemical Examination

ABSTRACT A case is described of a man of 48, who presented a history and clinical picture of a solitary thyro-hypophysial syndrome with malignant exophthalmos but in which general connective tissue changes were found on histological and histochemical examination of the retrobulbar connective tissue and muscles, of the pretibial connective and muscle tissue and the nasal epithelium. The intraocular tension was increased. In addition, renal failure developed. The use of cortisol locally in the eyes had a beneficial effect on the eye syndrome. Systemic treatment with corticotrophin and prednisolone had an evident beneficial effect on the renal condition.

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