scholarly journals Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)

2021 ◽  
Vol 92 ◽  
Author(s):  
Louise van der Weyden ◽  
Nicolize O’Dell ◽  
Alida Avenant ◽  
Paolo Pazzi ◽  
Katja N. Koeppel
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Successful Treatment ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Panthera Leo ◽  
African Lion ◽  
Hypofractionated Radiation Therapy ◽  
Hypofractionated Radiation

scholarly journals Weekly hypofractionated radiation therapy in elderly non-resectable cutaneous squamous cell carcinoma of the head and neck region

2020 ◽  
Author(s):  
Francesca De Felice ◽  
Daniela Musio ◽  
Vincenzo Tombolini
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Head And Neck ◽  
Squamous Cell ◽  
Neck Region ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Head And Neck Region ◽  
Hypofractionated Radiation Therapy ◽  
Hypofractionated Radiation

Abstract Introduction Treatment of inoperable cutaneous squamous cell carcinoma (cSCC) of the head and neck region is still debated. Case report We report an original case of cure of cSCC of the head and neck region with weekly hypofractionated radiation therapy with megavoltage electrons prescribed for locally advanced inoperable disease. Results Weekly hypofractionated radiotherapy assured complete regression and was well-tolerated. Conclusion The real efficacy of this treatment in the therapeutic arsenal remains to be defined. A clinical trial is ongoing to test the use of 8 weekly fractions of 8 Gy hypofractionated RT regimens in non-resectable cSCC cases.

A Systematic Review of Primary, Adjuvant, and Salvage Radiation Therapy for Cutaneous Squamous Cell Carcinoma

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Aimee E. Krausz ◽  
Antonio Ji-Xu ◽  
Timothy Smile ◽  
Shlomo Koyfman ◽  
Chrysalyne D. Schmults ◽  
...  
Keyword(s):  
Systematic Review ◽  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Salvage Radiation Therapy

Invasive Cutaneous Squamous Cell Carcinoma Presenting as a Nonhealing Radiation Wound

2011 ◽  
Vol 101 (4) ◽  
pp. 360-362
Author(s):  
Stephen J. Longobardi ◽  
Brian Sullivan ◽  
E. Hani Mansour
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
Skin Cancer ◽  
Cell Carcinoma ◽  
Malignant Transformation ◽  
Squamous Cell ◽  
Lower Extremities ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Invasive Squamous Cell Carcinoma ◽  
Negative Biopsy

Cutaneous squamous cell carcinoma is the second most common form of skin cancer and accounts for 20% of cutaneous malignancies. We report the case of a patient who presented with a complaint of nonhealing wounds following radiation therapy for the treatment of noninvasive squamous cell carcinoma of both lower extremities. Initial biopsies of the wounds were benign. However, a second biopsy performed approximately 2 months later was found to be positive for invasive squamous cell carcinoma. This case uniquely exemplifies that all nonhealing wounds should be viewed with a critical eye for possible malignancy even in the presence of previous negative biopsy. This is especially true for radiation wounds that may be prone to malignant transformation or recurrence. (J Am Podiatr Med Assoc 101(4): 360–362, 2011)

Outcomes in MAGE+ cutaneous squamous cell carcinoma with perineural invasion treated with surgery followed by postoperative radiation therapy.

2019 ◽  
Vol 37 (15_suppl) ◽  
pp. e21043-e21043
Author(s):  
Mary Stevenson ◽  
Alexis Santana ◽  
Nicole Adell Doudican ◽  
Theresa N Canavan ◽  
Anna C. Pavlick ◽  
...  
Keyword(s):  
Squamous Cell Carcinoma ◽  
Radiation Therapy ◽  
High Risk ◽  
Cell Carcinoma ◽  
Squamous Cell ◽  
Perineural Invasion ◽  
Cutaneous Squamous Cell Carcinoma ◽  
Postoperative Radiation Therapy ◽  
Worst Case ◽  
Potential Biomarker

e21043 Background: Perineural invasion (PNI) is associated with a high risk for recurrence and metastasis from cutaneous squamous cell carcinoma (cSCC). Recommendations vary regarding use of post-operative radiation therapy (PORT). Biomarkers for poor outcome from cSCC with PNI are lacking. We aimed to evaluate outcomes in high-risk cSCC with PNI treated surgically +/- PORT and to evaluate tissue from the primary tumor to identify biomarkers for highest risk. Methods: We conducted a retrospective chart review of PNI SCC patients seen between 2005 and 2014. We compared outcomes for surgery vs. surgery plus PORT. Gene expression from tumor debulk was evaluated via Nanostring. MAGEA3 function was evaluated using PAM 212 SCC cells in a BALB/c mouse model. CRISPR-Cas9 MAGEA3 PAM 212 knockouts were developed to assess role of MAGEA3 in SCC growth. Results: Thirty-two patients with PNI SCC were identified. All were treated surgically, and 18/32 elected to undergo PORT. Nodal metastases were noted in 5/14 patients who did not undergo PORT, whereas no metastases were noted in any patient who underwent PORT. Thus, surgery plus PORT was associated with better outcome than surgery alone (P < 0.01). Local recurrence was not observed in any patients treated by surgery, including 30 patients treated by Mohs micrographic surgery (MMS). MAGEA3 was highly expressed in PNI SCC. MAGEA3 expression in PAM 212 SCC was associated with tumor growth and increased expression of cyclins A, B, and E. CRISPR-Cas9 MAGEA3 PAM 212 knockouts exhibited reduced growth in BALB/c mice. Conclusions: MAGEA3 expression is increased in human PNI SCC. We can mitigate against worst case outcome with surgery plus PORT. MAGEA3 merits further investigation as a potential biomarker for best candidates for surgery plus PORT.

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