scholarly journals Bacterial vaginosis, alterations in vaginal flora and HIV genital shedding among HIV-1-infected women in Mozambique

2011 ◽  
Vol 12 (2) ◽  
pp. 22-24
Author(s):  
Robert D Kirkcaldy ◽  
Jennifer Mika ◽  
Lori M Newman ◽  
Judite Langa ◽  
Linhui Tian ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Odds Ratio ◽  
Vaginal Flora ◽  
Hiv Care ◽  
Normal Flora ◽  
Hiv Viral Load ◽  
Hiv Rna ◽  
Genital Shedding ◽  
Hiv 1 ◽  
Abnormal Vaginal Flora

Objectives. We investigated whether abnormal vaginal flora, including bacterial vaginosis (BV), are associated with detection of cervical HIV-1 RNA among HIV-infected women in Mozambique. Methods. We obtained clinical data and vaginal specimens from HIV-infected women registering for their first visit at one of two HIV care clinics in Mozambique. We compared women with detectable cervical HIV viral load (≥40 copies/ml) with women with undetectable cervical HIV. Results. We enrolled 106 women. Women with abnormal vaginal flora (intermediate Nugent scores, 4 - 6) were more likely to have detectable cervical HIV RNA then women with normal vaginal flora (adjusted odds ratio 7.2 (95% confidence interval 1.8 - 29.1), adjusted for CD4 count). Women with BV had a non-significantly higher likelihood of detectable cervical HIV than women with normal flora. Conclusions. Abnormal vaginal flora were significantly associated with cervical HIV expression. Further research is needed to confirm this relationship.

HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis

The Lancet ◽  
1997 ◽  
Vol 350 (9086) ◽  
pp. 1251-1252 ◽  
Author(s):  
S Ledru ◽  
N Méd ◽  
E Ledru ◽  
AJ Bazie ◽  
JP Chiron
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Flora ◽  
Hiv 1 ◽  
Abnormal Vaginal Flora

HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis

The Lancet ◽  
1997 ◽  
Vol 350 (9093) ◽  
pp. 1780 ◽  
Author(s):  
RH Gray ◽  
MJ Wawer ◽  
N Sewankambo ◽  
D Serwadda
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Flora ◽  
Hiv 1 ◽  
Abnormal Vaginal Flora

HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis

The Lancet ◽  
1997 ◽  
Vol 350 (9077) ◽  
pp. 546-550 ◽  
Author(s):  
Nelson Sewankambo ◽  
Ronald H Gray ◽  
Maria J Wawer ◽  
Lynn Paxton ◽  
Denise McNairn ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Flora ◽  
Hiv 1 ◽  
Abnormal Vaginal Flora

HIV-1 infection associated with abnormal vaginal flora morphology and bacterial vaginosis

The Lancet ◽  
1997 ◽  
Vol 350 (9086) ◽  
pp. 1251 ◽  
Author(s):  
Austin Ugwumadu ◽  
Phillip Hay ◽  
David Taylor-Robinson
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Flora ◽  
Hiv 1 ◽  
Abnormal Vaginal Flora

Aerobic vaginitis: Abnormal vaginal flora entity that is distinct from bacterial vaginosis

2005 ◽  
Vol 1279 ◽  
pp. 118-129 ◽  
Author(s):  
Gilbert G.G. Donders ◽  
Annie Vereecken ◽  
Eugene Bosmans ◽  
Alfons Dekeersmaecker ◽  
Geert Salembier ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Flora ◽  
Aerobic Vaginitis ◽  
Abnormal Vaginal Flora

scholarly journals Definition of a type of abnormal vaginal flora that is distinct from bacterial vaginosis: aerobic vaginitis

2002 ◽  
Vol 109 (1) ◽  
pp. 34-43 ◽  
Author(s):  
Gilbert G.G. Donders ◽  
Annie Vereecken ◽  
Eugene Bosmans ◽  
Alfons Dekeersmaecker ◽  
Geert Salembier ◽  
...  
Keyword(s):  
Bacterial Vaginosis ◽  
Vaginal Flora ◽  
Aerobic Vaginitis ◽  
Definition Of ◽  
Abnormal Vaginal Flora

scholarly journals Easiness of Use and Validity Testing ofVS-SENSEDevice for Detection of Abnormal Vaginal Flora and Bacterial Vaginosis

2010 ◽  
Vol 2010 ◽  
pp. 1-7 ◽  
Author(s):  
Gilbert G. G. Donders ◽  
Camila Marconi ◽  
Gert Bellen
Keyword(s):  
Bacterial Vaginosis ◽  
Common Sense ◽  
Vaginal Flora ◽  
Aerobic Vaginitis ◽  
Validity Testing ◽  
Vaginal Ph ◽  
Study Population ◽  
Test Specificity ◽  
Abnormal Vaginal Flora

Accessing vaginal pH is fundamental during gynaecological visit for the detection of abnormal vaginal flora (AVF), but use of pH strips may be time-consuming and difficult to interpret. The aim of this study was to evaluate theVS-SENSEtest (Common Sense Ltd, Caesarea, Israel) as a tool for the diagnosis of AVF and its correlation with abnormal pH and bacterial vaginosis (BV). The study population consisted of 45 women with vaginal pH≥4.5 and 45 women with normal pH. Vaginal samples were evaluated byVS-SENSEtest, microscopy and microbiologic cultures. Comparing with pH strips results,VS-SENSEtest specificity was 97.8% and sensitivity of 91%. All severe cases of BV and aerobic vaginitis (AV) were detected by the test. Only one case with normal pH had an unclear result. Concluding,VS-SENSEtest is easy to perform, and it correlates with increased pH, AVF, and the severe cases of BV and AV.

scholarly journals Relationship of Vaginal Bacteria and Inflammation With Conception and Early Pregnancy Loss FollowingIn-VitroFertilization

2003 ◽  
Vol 11 (1) ◽  
pp. 11-17 ◽  
Author(s):  
Linda O. Eckert ◽  
Donald E. Moore ◽  
Dorothy L. Patton ◽  
Kathy J. Agnew ◽  
David A. Eschenbach
Keyword(s):  
Hydrogen Peroxide ◽  
Bacterial Vaginosis ◽  
Live Birth ◽  
Early Pregnancy ◽  
Pregnancy Loss ◽  
Vaginal Flora ◽  
Early Pregnancy Loss ◽  
Gram Stain ◽  
Normal Flora ◽  
The Impact

Objective:The aim of this study was investigate the impact of vaginal flora and vaginal inflammation on conception and early pregnancy loss followingin-vitrofertilization (IVF).Methods:We enrolled 91 women who were undergoing IVF. At embryo transfer (ET), all of the women had quantitative vaginal culture, ET catheter-tip culture, and vaginal Gram stain scored for bacterial vaginosis and quantitated for polymorphonuclear leukocytes (PMNs). Conception and early pregnancy loss were compared with culture and Gram stain results. Statistical analyses included the Chi-square test, Fisher's exact test and the Mann–WhitneyU-test.Results:The overall live birth rate (LBR) was 30% (27/91), and the rate of early pregnancy loss was 34% (14/41). In women with bacterial vaginosis, intermediate flora and normal flora, the conception rates were 30% (3/10), 39% (12/31) and 52% (26/50), respectively (p= 0.06 for trend). Early pregnancy loss occurred in 33% (1/3), 42% (5/12) and 31% (8/26) of women, respectively (p= 0.06, comparing intermediate and normal flora). The vaginal log concentration of hydrogen peroxide-producing lactobacilli was 7.3 ± 1.7 in women with a live birth (n= 27) and 4.9 ± 2.5 in those with early pregnancy loss (n= 14) (p= 0.1).Conclusions:IVF patients with bacterial vaginosis and with a decreased vaginal log concentration of hydrogen peroxide-producing lactobacilli may have decreased conception rates and increased rates of early pregnancy loss. A larger prospective treatment trial designed to evaluate the impact on IVF outcomes of optimizing the vaginal flora prior to IVF may be warranted.

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