scholarly journals Synovial sarcoma

2014 ◽  
Vol 18 (2) ◽  
Author(s):  
Sucari S.C. Vlok ◽  
Georg W.W. Wagener ◽  
Dan Zaharie
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Soft Tissue Mass ◽  
Benign Lesion ◽  
Soft Tissue Sarcomas ◽  
Soft Tissue Tumour ◽  
Tissue Mass ◽  
Young Adult Patient ◽  
Tissue Tumour ◽  
Insidious Onset

Synovial sarcoma is a malignant, predominantly juxta-articular, soft-tissue tumour representing approximately 10% of all soft-tissue sarcomas. Frequently initially incorrectly diagnosed as a benign lesion, it should be considered as a diagnosis when a young adult patient presents with a calcified juxta-articular soft-tissue mass of insidious onset.

Synovial Sarcoma of the Cervical Spine: Case Report

2021 ◽  
Author(s):  
Nuno Oliveira ◽  
Sofia Carvalho ◽  
Paulo Cunha ◽  
Joni Nunes ◽  
Pedro Varanda ◽  
...  
Keyword(s):  
Case Report ◽  
Cervical Spine ◽  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Therapeutic Strategy ◽  
Osteolytic Lesion ◽  
Neurological Deficits ◽  
Soft Tissue Tumour ◽  
Tissue Tumour ◽  
Primary Bone

Abstract PurposeTo describe a very rare case of Synovial Sarcoma affecting cervical spine vertebra.SS is a rare malignant and aggressive soft tissue tumour arising from mesenchymal cells. Primary bone origin SS is a much rarer entity that affects more commonly long bones. Ideal therapeutic strategy is yet to be defined due to very small number of cases reported so far.Case reportA 55-year-old male, construction worker, with no other relevant medical history presented with a progressive tetraparesis after recurring several times during a 4-week period to assistant physician and emergency department complaining about bilateral shoulder pain. Image studies revealed an osteolytic lesion centred on C4 vertebra with intracanalar and intraforaminal extension, causing neurologic compression. Patient was submitted to urgent surgical decompression intervention. C3 and C4 corpectomy and excisional biopsy followed by stabilization with C2-C5 arthrodesis.OutcomesNeurological deficits did not improve after surgery. Histopathological and immunohistochemical analysis revealed phenotypical characteristics of a biphasic Synovial Sarcoma. Patient died 4 weeks after surgery due to a respiratory tract infection.DiscussionSS is a malignant rare and aggressive soft tissue tumour that usually affects young adults. Very few cases of primary bone SS affecting the spine are described in literature. Imaging studies may suggest the diagnosis of synovial sarcoma but definitive diagnosis can only be confirmed by histological and immunohistochemical analysis.The rarity of these lesions demands high clinical suspicion for the diagnosis and due to the low number of cases reported ideal therapeutic strategy is yet to be defined.

scholarly journals ‘‘Two-Week Waits’’—Are They Leading to Earlier Diagnosis of Soft-Tissue Sarcomas?

Sarcoma ◽  
2010 ◽  
Vol 2010 ◽  
pp. 1-3 ◽  
Author(s):  
W. St. J. Taylor ◽  
R. J. Grimer ◽  
S. R. Carter ◽  
R. M. Tillman ◽  
A. Abudu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Mass ◽  
Soft Tissue Sarcomas ◽  
Malignant Tumours ◽  
Tissue Mass ◽  
Borderline Lesion ◽  
Average Size ◽  
Malignant Diagnosis ◽  
Malignant Soft Tissue

Introduction. The ‘‘two-week wait’’ was established as a potential means of diagnosing malignant tumours earlier. This paper investigated whether these clinics are leading to earlier diagnosis of malignant soft-tissue lumps.Method. We identified all referrals to our centre from a database over a 4-year period.Results. 2225 patients were referred to our unit for investigation of a soft-tissue mass. 576 (26%) were referred under the ‘‘two-week wait’’ criteria. 153 (27%) of which were found to have a malignant or borderline malignant diagnosis. 1649 patients were referred nonurgently. 855 (52%) of which were diagnosed with a malignant or borderline lesion. The average size at diagnosis was 9.4 cm with no difference in size between the different referral routes.Conclusion. There is little evidence that the two-week wait clinic is leading to earlier diagnosis of soft-tissue sarcomas with the majority still being referred nonurgently.

scholarly journals Bone and Soft Tissue Tumours of the Foot: Review of 83 Cases

2002 ◽  
Vol 10 (2) ◽  
pp. 173-178 ◽  
Author(s):  
G Kinoshita ◽  
M Matsumoto ◽  
T Maruoka ◽  
T Shiraki ◽  
K Tsunemi ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Metastatic Cancer ◽  
Bone Tumour ◽  
Soft Tissue Sarcomas ◽  
Bone Cancer ◽  
Bone Tumours ◽  
Soft Tissue Tumour ◽  
Soft Tissue Tumours ◽  
Female Ratio ◽  
Tissue Tumour

Purpose. To review cases of bone and soft tissue tumours of the feet managed at the Hyogo College of Medicine, Nishinomiya and Takarazuka Municipal Hospital, Takarazuka, Japan. Methods. Retrospective analysis of 83 patient records treated for bone and soft tissue tumours of the feet between 1974 and 2000. Results. There were 33 benign bone tumours, one primary malignant bone tumour, and 2 metastatic bone cancer. Marginal resection was performed in cases of osteochondroma and curettage in cases of other benign bone tumour. Despite below-knee amputation in the case of chondrosarcoma, the patient died because of pulmonary metastasis. Two patients with metastatic cancer also died, and 2 cases of osteochondroma and one of benign chondroblastoma recurred. There were 47 cases of soft tissue tumour. Treatment for benign soft tissue tumours was marginal resection; no cases recurred. In contrast, all patients with soft tissue sarcoma died after surgery. The majority of bone tumours were located in the toe and hindfoot areas, in the first and second decades of life, whereas soft tissue tumours occurred mainly in the midfoot area and in patients aged between 20 and 50 years. The sex distribution was almost even for bone tumours (male: female ratio, 19: 17), whereas about half as many males as females had soft tissue tumours (14:33). Conclusion. Bone and soft tissue tumours of the feet are uncommon. Most bone tumours are chondrogenic, but differential diagnosis of malignant from benign disease is difficult and prognosis is poor. Management of benign tumours by marginal resection has good prognosis, whereas prognosis of soft tissue sarcomas is very poor.

scholarly journals Hind-Foot Synovial Sarcoma Treated With Wide Resection and Sural Fasciocutaneous Flap – A Case Report

2021 ◽  
pp. 1-3
Author(s):  
João Vale ◽  
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Benign Lesion ◽  
Surgical Techniques ◽  
Soft Tissue Sarcomas ◽  
Distal Region ◽  
Fasciocutaneous Flap ◽  
Wide Resection ◽  
Initial Growth ◽  
Hind Foot

Synovial sarcoma comprises about 5% to 10% of soft tissue sarcomas. Initial growth is often slow and a small circumscribed tumour may misleadingly appear to a benign lesion by clinical examination and imaging, occurring in up to 50% of cases. The modalities of treatment of foot malignant conditions depend on histological diagnosis and staging. A radical surgical procedure in the distal region of the lower limb is often difficult due to a limited soft-tissue situation and can result in soft-tissue defects. Plastic surgical techniques remain particularly indispensable in the treatment of such distal tumors. Authors present a hindfoot synovial sarcoma, diagnosed with a incisional biopsy, in which a wide margin surgery was achieved and a limb salvage was permitted by a sural fasciocutaneous flap.

scholarly journals Pulmonary Adenofibroma in an Elderly Male with Recurrent Soft Tissue Sarcoma

2021 ◽  
Author(s):  
Sandhya Devi Pasupathy ◽  
Archana Lakshmanan ◽  
S Annapurneswari
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Benign Lesion ◽  
Female Genital Tract ◽  
Anterior Segment ◽  
Pulmonary Blastoma ◽  
Soft Tissue Tumour ◽  
Biphasic Pattern ◽  
Tissue Tumour ◽  
Stromal Component

Pulmonary Adenofibroma (PAF) is a rare soft tissue tumour of the lung. It is a benign lesion, having a biphasic pattern with an admixture of epithelial and stromal components and has resemblance to fibroadenoma of the breast and adenofibroma of the female genital tract. The diagnosis can be challenging and it has to be delineated from other entities with biphasic pattern, like pulmonary hamartoma, pulmonary blastoma, intrapulmonary solitary fibrous tumour and metastases from soft tissue and visceral sarcomas, as each tumour has its own therapeutic and prognostic implications. Here, we report a case of a 73-year-old male, a known case of recurrent soft tissue sarcoma of the thigh, who presented with solitary pulmonary lesion. The patient was a non-smoker and did not have any specific respiratory complaints. On staging work-up with a Positron Emission Tomography and Computed Tomography (PET-CT), a hypermetabolic lesion was identified in the anterior segment of right upper lobe of the lung, following which he underwent right lobectomy. The tumour was a solitary lesion located near the hilum and on histology showed a biphasic pattern with scattered glandular spaces lined by columnar epithelium set in a hyalinised spindle cell stroma. The cells showed mild pleomorphism with oval to elongated nuclei and indistinct cytoplasm. On immunohistochemistry, the epithelial component showed positivity for Cytokeratin (CK), Epithelial Membrane Antigen (EMA), Thyroid Transcription Factor-1 (TTF-1) and Napsin-A and the stromal component showed positivity for Vimentin, Desmin, Smooth Muscle Actin (SMA) and H-Caldesmon (High molecular weight isoform-Caldesmon). With the given histological and immunohistochemistry findings, a diagnosis of PAF was rendered.

scholarly journals Monophasic Synovial Sarcoma Presenting as Infantile Hemangioma: A Case Report

2020 ◽  
Author(s):  
Abdulrahman Fahad Al Kandari ◽  
Abdulwahab Fahad Alkandari ◽  
Sarah Faisal Alhendi ◽  
Hussain Saleh Almousawi ◽  
Hisham Adel Burezq
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Clinical Features ◽  
Beta Blocker ◽  
Soft Tissue Mass ◽  
Infantile Hemangioma ◽  
Left Forearm ◽  
Tissue Mass ◽  
Blocker Therapy

Abstract Objective: This report describes a case of a monophasic synovial sarcoma that was initially misdiagnosed as an infantile hemangioma in a 3-month-old female infant. We also discuss the basic elements of evaluating a soft-tissue mass and important radiological and clinical features that should raise the index of suspicion for a synovial sarcoma. Summary Background Data: Synovial sarcoma is a rare pathology that is often challenging to diagnose due to its similarities with more common vascular lesions that occur in infancy. Infantile hemangioma, in particular, is common, has distinctive clinical and radiological findings, and is frequently diagnosed without histological confirmation. This increases the risk of misdiagnosis of rare tumors in infancy. Case Report: A 3-month-old female infant presented with a soft-tissue mass on the left forearm. Physical examination showed a well-defined, subcutaneous mass on the left forearm, measuring approximately 3 cm × 5 cm, firm in consistency, with no cutaneous involvement and normal skin coverage. Imaging suggested an infantile hemangioma but, due to the atypical presentation, a trial of beta-blocker therapy was conducted to confirm the diagnosis. The patient showed no clinical response to beta-blocker therapy, and therefore an incisional biopsy was performed. Using histopathology, the tumor was diagnosed as a monophasic synovial sarcoma.Conclusions: We highlight a rare presentation of a synovial sarcoma in a neonate and caution against making a diagnosis without histopathologic analysis. Clinicians should include sarcoma in the differential diagnosis when assessing a mass in neonates, as early diagnosis and intervention can reduce morbidity and mortality.MINI ABSTRACT A 3-month-old infant presented with a left forearm soft-tissue mass, initially diagnosed as infantile hemangioma. Biopsy revealed a monophasic synovial sarcoma. We discuss the basic elements of evaluating a soft-tissue mass and important radiological and clinical features that should raise the index of suspicion for a synovial sarcoma.

scholarly journals Non-rhabdomyosarcoma soft tissue sarcoma in a neonate, a rare and aggressive disease: case report

2018 ◽  
Vol 6 (1) ◽  
pp. 209
Author(s):  
Tanvi Khanna ◽  
Kunal Das ◽  
B. P. Kalra
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcoma ◽  
Anterior Abdominal Wall ◽  
Soft Tissue Mass ◽  
Soft Tissue Sarcomas ◽  
Surgical Excision ◽  
Tissue Mass ◽  
Disease Case ◽  
Variable Success ◽  
Rare Group

Neonatal soft tissue sarcomas are a rare group of tumors. The behavior and aggressiveness of neonatal STS is variable. Surgical excision has been noted to be most important factor affecting outcome. However, when non-mutilating surgery is not possible, or resection is incomplete, chemotherapy and radiotherapy have been tried with variable success. We encountered a case of a neonate having large soft tissue mass at anterior abdominal wall. Biopsy and immunohistochemistry confirmed it as undifferentiated soft tissue sarcoma. Surgical excision was incomplete with margin positivity. His disease showed recurrence in short duration of time and despite adjuvant chemotherapy, progression was noted. The child abandoned the treatment and died within 3 months of life.

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