scholarly journals Hind-Foot Synovial Sarcoma Treated With Wide Resection and Sural Fasciocutaneous Flap – A Case Report

2021 ◽  
pp. 1-3
Author(s):  
João Vale ◽  
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Benign Lesion ◽  
Surgical Techniques ◽  
Soft Tissue Sarcomas ◽  
Distal Region ◽  
Fasciocutaneous Flap ◽  
Wide Resection ◽  
Initial Growth ◽  
Hind Foot

Synovial sarcoma comprises about 5% to 10% of soft tissue sarcomas. Initial growth is often slow and a small circumscribed tumour may misleadingly appear to a benign lesion by clinical examination and imaging, occurring in up to 50% of cases. The modalities of treatment of foot malignant conditions depend on histological diagnosis and staging. A radical surgical procedure in the distal region of the lower limb is often difficult due to a limited soft-tissue situation and can result in soft-tissue defects. Plastic surgical techniques remain particularly indispensable in the treatment of such distal tumors. Authors present a hindfoot synovial sarcoma, diagnosed with a incisional biopsy, in which a wide margin surgery was achieved and a limb salvage was permitted by a sural fasciocutaneous flap.

scholarly journals Synovial sarcoma

2014 ◽  
Vol 18 (2) ◽  
Author(s):  
Sucari S.C. Vlok ◽  
Georg W.W. Wagener ◽  
Dan Zaharie
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Soft Tissue Mass ◽  
Benign Lesion ◽  
Soft Tissue Sarcomas ◽  
Soft Tissue Tumour ◽  
Tissue Mass ◽  
Young Adult Patient ◽  
Tissue Tumour ◽  
Insidious Onset

Synovial sarcoma is a malignant, predominantly juxta-articular, soft-tissue tumour representing approximately 10% of all soft-tissue sarcomas. Frequently initially incorrectly diagnosed as a benign lesion, it should be considered as a diagnosis when a young adult patient presents with a calcified juxta-articular soft-tissue mass of insidious onset.

scholarly journals Monophasic Synovial Sarcoma of the Infratemporal Fossa—Case Report and Review of the Literature

2017 ◽  
Vol 13 (01) ◽  
pp. 01
Author(s):  
Ignacio Mendoza ◽  
Ilson Sepúlveda ◽  
Geraldine Ayres ◽  
◽  
◽  
...  
Keyword(s):  
Case Report ◽  
Soft Tissue ◽  
South America ◽  
Head And Neck ◽  
Synovial Sarcoma ◽  
Infratemporal Fossa ◽  
Soft Tissue Sarcomas ◽  
Complete Resection ◽  
Review Of The Literature ◽  
Histological Features

Synovial sarcoma (SS) represents about 10% of all soft tissue sarcomas. It is believed that its origin would be found in cells that are related neither to ultrastructural nor to histological features of the synovial tissue. Head and neck is very rarely affected, with the lower extremities being most frequent. Complete resection with or without radiotherapy and chemotherapy is currently considered the best available therapy. This time we present the case of a patient with SS located in the infratemporal fossa, its diagnosis, treatment and evolution. According to our knowledge it is the first reported case in South America.

scholarly journals The Therapeutic Approach of Soft – Tissue Sarcomas. A 12 Cases Analysis

2018 ◽  
Vol 1 (Supplement) ◽  
pp. 58
Author(s):  
V. Georgeanu ◽  
T. Atasiei ◽  
D. Gartonea ◽  
B. Shazam ◽  
G. Goleşteanu ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Local Recurrence ◽  
Synovial Sarcoma ◽  
Therapeutic Approach ◽  
Clear Cell ◽  
Postoperative Radiotherapy ◽  
Soft Tissue Sarcomas ◽  
Clear Cell Sarcoma ◽  
Cell Sarcoma ◽  
Special Cases

Abstract Introduction. Soft Tissue Sarcomas (STS) is a group of rare malignant tumors with mesenchymal tissue origin. At present, over 50 histopathological types with typical chromosome changes are described. Treatment is multidisciplinary, centered on the surgical approach. Method. Between 2014 and 2016, 12 STS cases were treated in our clinic: 3 liposarcomas, 2 synovial sarcomas, 1 angiosarcoma, 2 rhabdomyosarcomas, 2 myxofibrosarcomas, 1 fibroblast sarcoma and 1 clear cell sarcoma. With the exception of angiosarcoma that benefited only from chemotherapy, the other cases were surgically approached, followed by radiotherapy in 7 cases, and chemotherapy in one case. Results. Patient follow-up was for a minimum of 2 years. In 3 cases (fibroblast sarcoma, clear-cell sarcoma, synovial sarcoma), a local recurrence occurred between 3 and 9 months. In 2 cases (fibroblastic sarcoma, synovial sarcoma), pulmonary metastases occurred between 6 and 18 months and the patients died at 8 months and 2 years respectively. The rest of the cases were clinically and imagistically assessed (local MRI, lung CT) at 6 months for at least 2 years and showed no signs of local recurrence or metastasis. Conclusions. The evolution of STS depends on the histological type and to the stage of diagnosis (local extension, degree of differentiation and presence of metastases). Therapeutic approach should be centered on an accurate resection, within the limits of oncological safety even with re-resection. Postoperative radiotherapy is used in most of the cases, and chemotherapy is reserved for special cases with unfavorable local evolution or metastasis.

scholarly journals Synovial sarcoma presenting as subcutaneous swelling: a rare presentation

2019 ◽  
Vol 6 (6) ◽  
pp. 2190
Author(s):  
Dheer S. Kalwaniya ◽  
Jaspreet S. Bajwa
Keyword(s):  
Soft Tissue ◽  
Early Diagnosis ◽  
Knee Joint ◽  
Synovial Sarcoma ◽  
Lower Risk ◽  
Soft Tissue Sarcomas ◽  
Synovial Cells ◽  
Rare Presentation

Synovial sarcoma unlike its name is not originating from synovial cells. It accounts for approximately 10% of all soft tissue sarcomas with main predilection for extremities.We present here a case of synovial sarcoma of subcutaneous origin of knee joint which is rarest of presentations and early diagnosis is associated with lower risk of metastasis and hence better prognosis.

Epidemiology of patients with musculoskeletal soft tissue sarcomas in a cancer hospital in Central China: A study of 1624 cases.

2020 ◽  
Author(s):  
Peng Zhang ◽  
Jinyan Liu ◽  
Feifei Feng ◽  
Qiao Zhang ◽  
Guangcai Duan ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Soft Tissue Sarcomas ◽  
Tumor Location ◽  
Henan Province ◽  
Central China ◽  
Gender Ratio ◽  
Pathological Type ◽  
Cancer Hospital ◽  
Pathological Subtypes

Abstract Background : To analyze the incidence characteristics of 1624 inpatients with soft tissue sarcoma (STS) during 2006 to 2016 in Henan Province Cancer Hospital in Central China. Methods : The information of electronic medical record from the first hospitalized patients with STS in Henan Province Cancer Hospital during January 1, 2006 to December 31, 2016 was collected, and descriptive statistics was analyzed on age, gender, pathological type and tumor location by using SPSS21.0 software. Results : There were 1624 inpatients with STS in Henan Province Cancer Hospital in 2006~2016.The top nine pathological subtypes of STS with high constituent ratio were undifferentiated pleomorphic sarcoma (UPS,23.83%),synovial sarcoma(16.69%), liposarcoma(13.67%), fibrosarcoma(10.22%), sarcoma without definite type (8.99%), leiomyosarcoma(7.02%), dermatofibrosarcoma protuberant (5.79%),rhabdomyosarcoma (4.68%) and malignant neurilemmoma(4.25%). The average age of inpatients was 44.71±17.91, and the inpatients aged 35-64 accounted for 56.34%.The number of UPS inpatients reached the peak at the age of 45 to 59; The median age of inpatients with rhabdomyosarcoma was 17 year.In total 1624 inpatients of STS, the number of male and female inpatients were 923 and 701, respectively. The gender ratio was 1.32:1. The proportion of UPS in either male or female inpatients was the highest, accounting for 23.07% and 24.82%, respectively. The number of male inpatients was more than that of female in the top nine pathological subtypes of STS except leiomyosarcoma (the gender ratio was 0.84:1). The most common initiation location of UPS, synovial sarcoma, liposarcoma was lower extremity, accounting for 51.16%, 53.13% and 52.25% in corresponding pathological type group, respectively. Dermatofibrosarcoma protuberant, rhabdomyosarcoma and fibrosarcoma were all mainly initiated in trunk, accounting for 72.34%, 47.83% and 45.57% , respectively. Leiomyosarcoma tend to occur in retroperitoneum. Conclusion : The top three pathological subtypes of STS with high constituent ratio were UPS, synovial sarcoma and liposarcoma.UPS should be paid more attention on the prevention, treatment and research in Henan province in future for its highest proportion of STS.

Microsurgical Reconstructions Following Wide Resection of Bone and Soft Tissue Sarcomas in the Extremities

1989 ◽  
pp. 661-666 ◽  
Author(s):  
Masamichi Usui ◽  
Seiichi Ishii ◽  
Toshikatsu Matsuyama ◽  
Susumu Asano ◽  
Shinya Yamawaki ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Wide Resection

scholarly journals Wide resection of soft tissue sarcomas after unplanned primary procedures

Medicine ◽  
2020 ◽  
Vol 99 (8) ◽  
pp. e19067 ◽  
Author(s):  
Jian Kang ◽  
Ming Xu ◽  
Bing Wang ◽  
Xiuchun Yu
Keyword(s):  
Soft Tissue ◽  
Soft Tissue Sarcomas ◽  
Wide Resection

Genetic landscape of soft-tissue sarcomas: Moving toward personalized medicine.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 11002-11002 ◽  
Author(s):  
Antoine Italiano ◽  
Emmanuel Khalifa ◽  
Yec'han Laizet ◽  
Maud Toulmonde ◽  
Sophie Cousin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Copy Number ◽  
Copy Number Alteration ◽  
Clinical Decision Making ◽  
Fusion Gene ◽  
Significant Proportion ◽  
Soft Tissue Sarcomas ◽  
Clinical Decision ◽  
Molecular Abnormalities

11002 Background: Patients with advanced soft-tissue sarcomas have a very poor outcome with a median overall survival of less than 18 months. Identification of molecular abnormalities for which targeted therapies are available or can be developed is critical for improving their outcomes. Methods: We have analyzed the mutational and copy number profiles of patients with sarcoma sequenced through the AACR Project GENIE Consortium in order to identify the proportion of cases bearing actionable mutation. Results: 587 patients (pts) were included in the study (295 males). 331 pts (56%) had complex genomics sarcomas, 144 (25%) translocation-related sarcomas and 112 (19%) others sarcomas (inactivating mutation, simple amplicon). The five most frequent histology were: Leiomyosarcoma (n = 112; 19.1%); Undifferentiated Pleomorphic Sarcomas (n = 74, 12.6%), dedifferentiated liposarcoma (n = 55, 9.4 %), angiosarcoma (n = 43, 7.3%), synovial sarcoma (n = 38, 6.5%). 430 pts (73%) had at least one mutation. The ten most frequently mutated genes were: TP53 (34.7%); ATRX (9.1%), RB1 (8.4%), KMT2D (5.8%), NF1 (5.3%), ATM (5.1%), PI3KCA (4.9%), ERBB4 (4.2%), PTEN (4%), and ARID1A (3.7%). 504 patients (85.9%) presented at least one copy number alteration. The 5 five most frequently amplified genes were: MDM2 (20%), CDK4 (16.7%), GLI1, MAP2KA, and TERT (3.2% for each gene), and the most frequently deleted were RB1 (12.7%), CDKN2A (10.3%), CDKN2B (9.7%), TP53(9.5%), PTEN (8.5). 92.5% of pts had at least one targetable mutation, copy number alteration and/or fusion gene ( Leiomyosarcoma n = 100/17%, UPS n = 74/12%, dedifferentiated diposarcoma n = 54/9%, angiosarcoma n = 41/7%, synovial Sarcoma n = 36/6%), with incidences reported that will be reported in details at the meeting. Conclusions: This is the first large report of genomic landscape including mutation and copy number profiling through NGS of soft-tissue sarcomas. Our results indicate a significant proportion of actionable mutations and represent a rationale for the MULTISARC study: the first study implementing Exome Seq and RNA Seq for clinical decision making in patients with advanced STS. The design of this study supported by the French government and launched in 09/2017 will be presented at the meeting.

Genomic index in pediatric synovial sarcoma (SYNOBIO study): The European Pediatric Soft Tissue Sarcoma Group (EpSSG) experience.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10529-10529
Author(s):  
Daniel Orbach ◽  
Veronique Mosseri ◽  
Daniel Pissaloux ◽  
Bernadette Brennan ◽  
Andrea Ferrari ◽  
...  
Keyword(s):  
Prognostic Factor ◽  
Soft Tissue ◽  
Synovial Sarcoma ◽  
Soft Tissue Sarcomas ◽  
Fusion Transcript ◽  
Risk Groups ◽  
Comparative Genomic ◽  
Perioperative Therapy ◽  
Free Survival ◽  
Flat Profile

10529 Background: A genomic index (GI) tool using array comparative genomic hybridization (aCGH) on tumor cells has recently been developed, and shown a high prognostic value in adult soft tissue sarcomas. GI correlates with genomic instability, and has emerged as independent prognostic factor associated with the risk of metastases developing in synovial sarcoma (SS). The aim, therefore, was to assess GI in pediatric patients with SS, to assess its value as a prognostic factor and its role in risk stratification. Methods: All pediatric/adolescent/young adults’ (<25 years) with localized SS prospectively included in the European EpSSG-NRSTS05 protocol with a contributive aCGH were selected. Tumors had a central pathological review or harbored the specific fusion transcript (SYT-SSX). Definition of GI was A2/C, where A is the total number of alterations (segmental gains and losses) and C is the number of involved chromosomes on aCGH results. GI1 group corresponds to cases with no or few alterations (flat profile, GI≤1) and GI2 group cases with many alterations (complex CGH profile; GI>1). Results: A total of 48 patient’s samples were available. The median age of the cohort was 13 years (range: 4-24). Patients received surgery only (19%), with adjuvant therapy (17%) or perioperative therapy (64%). GI1 group corresponded to 54.2%, and GI2 to 45.8%. After a median follow up of 58 months (range: 0.1-107), 10 tumor events occurred and 5 patients died. Patients with high GI have more axial (P<0.01), invasive (P=0.04) and higher therapeutic risk groups’ tumors (unresectable/axial tumors; P<0.015). Respectively for GI1 vs. GI2 groups, 5-year event free survival (EFS) rates were 91.8±5.6% vs. 58.9±11.2% (P<0.0084) and 5Y-Metastatic Free Survival 91.8±5.5% vs. 68.6±10.6% (P=0.055). In multivariate analysis, GI adjusted for IRS groups, site and tumor size remains prognostic for EFS (P<0.025). Conclusions: Although tumor events were rare for SS in NRSTS 2005, high GI selected patients with high risk tumor features and predicted a poorer outcome. GI may explain aggressive behavior of some pediatric SS. Founding sources: “Enfant-et-santé/SFCE,” “Info sarcome,” and “La ligue contre le cancer.”

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