scholarly journals Biochemical and histological study of granulation tissue to evaluate the effect of limited access dressing in chronic wounds: A comparative study

2015 ◽  
Vol 48 (01) ◽  
pp. 028-029
Author(s):  
Air Mshl Anil Behl ◽  
Pauline Babu ◽  
Pallab Chatterjee
Keyword(s):  
Comparative Study ◽  
Granulation Tissue ◽  
Chronic Wounds ◽  
Histological Study ◽  
Limited Access

scholarly journals Effects of limited access dressing in chronic wounds: A biochemical and histological study

2015 ◽  
Vol 48 (01) ◽  
pp. 022-028 ◽  
Author(s):  
Thittamaranahalli Muguregowda Honnegowda ◽  
Pramod Kumar ◽  
Padmanabha Udupa E G ◽  
Anurag Sharan ◽  
Rekha Singh ◽  
...  
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Total Protein ◽  
Inflammatory Infiltrate ◽  
Chronic Wounds ◽  
Histological Study ◽  
Inflammatory Cells ◽  
Collagen Deposition ◽  
Pressure Therapy ◽  
Limited Access

ABSTRACT Background: Negative pressure wound therapy has emerged as an attractive treatment modality for the management and healing of chronic ulcers. Though numerous clinical studies are available, there is a lack of biochemical and histological studies evaluating the healing of chronic wounds. Materials and Methods: In the present study, a total 60 patients were divided into two groups: Limited access dressing (LAD) group (n = 30) and conventional dressing group (n = 30). Various biochemical parameters such as hydroxyproline, total protein and antioxidants such as reduced glutathione (GSH), glutathione peroxidase (GPx), catalase (CAT) and oxidative biomarker malondialdhyde (MDA) are measured in the granulation tissue. Histologically amount of inflammatory infiltrate, angiogenesis, and collagen deposition are studied to assess wound healing. Results: Patients treated with LAD have shown significant increase in the mean (±standard deviation) hydroxyproline (77.3 ± 30.1 vs. 32.3 ± 16.18; P = 0.026), total protein (13.89 ± 9.0 vs. 8.9 ± 4.59; P = 0.004), GSH (7.4 ± 1.91 vs. 5.1 ± 1.28; P = 0.039), GPx (122.3 ± 59.3 vs. 88.7 ± 34.11; P = 0.030), CAT (1.80 ± 1.14 vs. 0.9 ± 0.71; P = 0.002) and decrease in MDA (13.4 ± 5.5 vs. 8.6 ± 3.8; P = 0.004). Histological study showed comparatively fewer inflammatory cells, increased and well organised collagen bundles, and more angiogenesis in the LAD group when compared with that with conventional dressing after 10 days of treatment. Conclusion: In the present study, we have found beneficial effect of newer intermittent negative pressure therapy in combination with moist environment (LAD) on chronic wound healing by increasing collagen deposition and angiogenesis; and reducing oxidative stress and inflammatory infiltrate.

Comparative study of skin grafting with and without surgical removal of granulation tissue in chronic burn wounds

Burns ◽  
2007 ◽  
Vol 33 (7) ◽  
pp. 872-878 ◽  
Author(s):  
Sanjay Dhar ◽  
Rakesh Saraf ◽  
Anand K. Gupta ◽  
Bhavani Raina
Keyword(s):  
Comparative Study ◽  
Granulation Tissue ◽  
Skin Grafting ◽  
Surgical Removal ◽  
Burn Wounds

scholarly journals A comparative study of the efficacy of topical negative pressure moist dressings and conventional moist dressings in chronic wounds

2007 ◽  
Vol 40 (2) ◽  
pp. 133 ◽  
Author(s):  
LeoFrancis Tauro ◽  
J Ravikrishnan ◽  
BS Satish Rao ◽  
HDivakar Shenoy ◽  
SR Shetty ◽  
...  
Keyword(s):  
Comparative Study ◽  
Negative Pressure ◽  
Chronic Wounds ◽  
Topical Negative Pressure

scholarly journals A Comparative Study of Honey and Phenytoin Dressings for Chronic Wounds

2015 ◽  
Vol 77 (S3) ◽  
pp. 1209-1213 ◽  
Author(s):  
Siddharth P. Dubhashi ◽  
Rajat D. Sindwani
Keyword(s):  
Comparative Study ◽  
Chronic Wounds

scholarly journals Exploiting potency of negative pressure in wound dressing using limited access dressing and suction-assisted dressing

2012 ◽  
Vol 45 (02) ◽  
pp. 302-315 ◽  
Author(s):  
Pramod Kumar
Keyword(s):  
Wound Healing ◽  
Negative Pressure ◽  
Wound Dressing ◽  
Chronic Wounds ◽  
Bacterial Invasion ◽  
Limited Access ◽  
Advantages And Disadvantages ◽  
Superficial Skin ◽  
Excellent Research ◽  
Pressure Dressing

ABSTRACTRole of negative pressure dressing and moist wound healing are well established in the treatment of both acute and chronic wounds with certain advantages and disadvantages in both the techniques. Both these techniques prevents wound colonization, but the negative pressure dressing method has proved to have a greater potency to remove secretions, prevent wound invasion and eradication established infection. In both these techniques there is no accessibility to wound environment. Limited access dressing (LAD) is a moist wound dressing with negative pressure. It provides limited access to the wound through two small ports for both dressers and pathogens. The LAD design has notable advantages like wound isolation that reduces chance of wound colonization and safe disposal of infected materials (important factor to reduce hospital-acquired infections), while avoiding some major disadvantages such as opacity of dressing materials, inaccessible offensive smelling wound environment, and relatively high treatment costs. In LAD a definite intermittent negative pressure regimen is followed. The intermittent negative pressure (cycle of 30 minutes suction and 3 1 / 2 hours rest) is effective. Overall, the LAD is a safe and effective alternative to conventional dressing methods. LAD is an excellent research tool for wound healing as frequent/continuous record of wound healing is possible without disturbing the wound healing process. LAD is an effective dressing for limb salvage in cases of acute and chronic complex wounds. Leech effect prevents wound related systematic response syndrome and sepsis. Suction-assisted dressing (SAD) is a combination of semiocclusive dressing with negative pressure. It works by removal of fluids by intermittent (like LAD) negative pressure and preventing bacterial invasion. SAD is especially advantageous where soakage is less, there is no dead tissue covering the wound (e.g., following skin grafting), superficial skin wounds (e.g., donor area) and also where LAD is technically difficult to apply over circumferential trunk and neck dressings under anesthesia.

A comparative study of phenytoin dressing versus honey dressing in the treatment of cronic ulcers in tertiary care hospital

2021 ◽  
Vol 19 (1) ◽  
pp. 05-09
Author(s):  
Sandesh M ◽  
Keyword(s):  
Wound Healing ◽  
Granulation Tissue ◽  
Chronic Wounds ◽  
Tertiary Care ◽  
Skin Grafting ◽  
Care Hospital ◽  
Tissue Formation ◽  
Granulation Tissue Formation ◽  
Diabetic Ulcers

Background: Diabetic foot infections are the leading cause of hospitalization morbidity and mortality in diabetics worldwide In India it accounts for 20% of hospitalizations. honey has been investigated to treat ulcers like pressure ulcers, venous ulcers, diabetic ulcers, traumatic wounds and burns. Phenytoin is also now known to promote wound healing and can be an alternative to normal saline specifically in chronic wounds related to diabetes. The present study compares these two modalities in management of diabetic ulcers. Objective: To compare the efficacy of topical phenytoin vs topical honey in chronic diabetic ulcers in terms of rate of wound healing, granulation tissue formation and quality of graft bed for skin grafting. Methods: A comparative prospective study of 50 patients with chronic diabetic ulcers selected based on a predefined criteria divided into two groups: Group A (Phenytoin group) (n=25) and Group B (honey group) (n=25). Final wound area was measured on 30th day. Comparison between the wound size reduction among two groups done at end of 30th day. Outcome was measured in terms of wound reduction, granulation tissue formation and quality of bed for skin grafting between the two groups. Results: This study has shown faster rate of wound healing, better granulation tissue formation and quality graft bed for skin grafting in patients who received topical phenytoin dressing as compared to topical honey dressing.

COLLAGEN DRESSING VERSUS CONVENTIONAL DRESSINGS IN BURN AND CHRONIC WOUNDS: A COMPARATIVE STUDY

2021 ◽  
pp. 43-45
Author(s):  
Sujeet Kumar Bharti ◽  
Kirti Priya
Keyword(s):  
Granulation Tissue ◽  
Chronic Wounds ◽  
Skin Grafting ◽  
Conventional Group ◽  
Wound Surface ◽  
Early Conclusion ◽  
Patients Satisfaction ◽  
Collagen Group ◽  
Split Skin Grafting ◽  
Split Skin

Objective: Biological dressings are water-resistant to bacteria, and generate the most physiological interfacebetween the wound surface and the environment. Collagen dressings have other superiority over conventional dressings in terms of ease of application and being natural, non-immunogenic, non-pyrogenic, hypoallergenic, and pain-free. Materials And Methods: The data of 120 patients with chronic wounds of diverse aetiologies and with signify age 43.7 years were accumulated and analyzed. The patients had been treated with collagen or other conventional dressing substance. The patients were split into two groups; 'Collagen group' and 'Conventional group', For the cause of comparison. 60 patients wereincluded in both groups. For assessment the wound characteristics in size, edge, oor, granulation tissue, and wound swab were recorded. With starting treatment, appearance of granulation tissue, completeness of healing, require for skin grafting, and patients' satisfaction was noted in both groups. Results: Sixty percentage of the 'collagen group' wounds and only forty-two percentage of the 'conventionalgroup' wounds were sterile (P=0.04) within two weeks of treatment. Healthy granulation tissue seemed earlier over collagen-dressed woundsthan over conventionally treated wounds (P=0.04). After eight weeks, (87%) of 'collagen group' wounds and (80%) of 'conventional group' wounds were >75% healed (P=0.21). In the 'collagen group' eight patients and twelvein the 'conventional group' required partial split-skin grafting (P=0.05). Collagen-treated patients enjoyed early. Conclusion: No remarkable better results were found in terms of complete of healing of burn andchronic wounds between collagen dressing and conventional dressing. Collagen dressing, however, mayavoid the require of skin grafting, and provides additional benet of patients' comfort.

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