Local delivery of hyaluronan 0.8% as an adjunct to scaling and root planing in the treatment of chronic periodontitis: A clinical and microbiological study

AbstractThe current understanding of the pathogenesis of periodontal disease has resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The objective of this investigation was to assess the efficacy of atorvastatin and simvastatin (because of their pleiotropic properties) as an adjunct to dental scaling and root planing (SRP) by local delivery, i.e. placing them subgingivally, in the treatment of chronic periodontitis.Local delivery systems for atorvastatin and simvastatin were prepared in sodium alginate suspension to be administered with calcium chloride solution. Patients diagnosed with chronic periodontitis were grouped as group 1, receiving SRP only (control), group 2, receiving SRP with subgingival delivery of 1.2% simvastatin, and group 3, receiving SRP with subgingival delivery of 1.2% atorvastatin. Clinical parameters and interleukin (IL) 1α levels in the gingival crevicular fluid (GCF) were assessed.All three groups showed significant reductions in clinical parameters and IL-1α levels in the GCF (p<0.05). However, the test groups did not show any statistically significant difference when compared with control.Subgingivally delivered atorvastatin and simvastatin as an adjunct to SRP is efficacious but did not demonstrate any added benefit as compared with SRP alone.

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Comparative evaluation of silver nanoparticle gel and chlorhexidine gel as an adjunct to scaling and root planing in management of chronic periodontitis–A clinico-microbiological study

Journal of Dental Specialities ◽

10.18231/j.jds.2019.022 ◽

2020 ◽

Vol 7 (2) ◽

pp. 89-94

Author(s):

Udbhabana Kalita ◽

◽

Varun Kumar Tyagi ◽

Swyeta Jain Gupta ◽

Shubhra Vaish ◽

...

Keyword(s):

Silver Nanoparticle ◽

Chronic Periodontitis ◽

Comparative Evaluation ◽

Scaling And Root Planing ◽

Microbiological Study ◽

Root Planing ◽

Chlorhexidine Gel

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Evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: A clinical and microbiological study

Journal of Indian Society of Periodontology ◽

10.4103/0972-124x.82264 ◽

2011 ◽

Vol 15 (1) ◽

pp. 35 ◽

Cited By ~ 12

Author(s):

AmitaM Mali ◽

SuhitS Gilda ◽

AnantR Paradkar ◽

Roobal Behal

Keyword(s):

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Chronic Periodontitis ◽

Local Drug Delivery ◽

Scaling And Root Planing ◽

Microbiological Study ◽

Root Planing ◽

Local Drug Delivery System

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Efficacy of Oral Probiotics as an Adjunct to Scaling and Root Planing in Nonsurgical Treatment Outcome of Generalized Chronic Periodontitis Patients: A Clinico-Microbiological Study

International Journal of Experimental Dental Science ◽

10.5005/jp-journals-10029-1145 ◽

2017 ◽

Vol 6 (1) ◽

pp. 6-13 ◽

Cited By ~ 1

Author(s):

Ameet Mani ◽

Shubangi Mani ◽

Sugandha R Saini

Keyword(s):

Treatment Outcome ◽

Chronic Periodontitis ◽

Nonsurgical Treatment ◽

Control Group ◽

Scaling And Root Planing ◽

Once Daily ◽

Microbiological Study ◽

Root Planing ◽

Group I ◽

Group Ii

ABSTRACT Aim: This study aims to find out the effects of Probiotics, delivered with a lozenge for its effect on clinical and microbiological parameters in subjects with chronic periodontitis after scaling and root planing (SRP). Materials and methods: A total of 40 generalized mild to moderate chronic periodontitis subjects were finally enrolled in a double-blind, placebo-controlled, randomized clinical study. Selected subjects after SRP were randomly divided into two groups: Group I (test group) with 20 subjects receiving probiotic tablet once daily and group II (control group) receiving placebo tablets once daily. Clinical parameters and bacterial count for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum were evaluated at baseline, 2, and 4 months after the medication. Results: On comparative evaluation between the two groups, results indicated that group I (probiotic group) exhibited statistically significant reduction in both clinical and microbiological levels than group II (control group) over the entire span of the study. Conclusion: Our results proved that daily oral supplementation of probiotics could be a useful adjunct to SRP in chronic periodontitis patients. How to cite this article Mani A, Saini R, Saini SR. Efficacy of Oral Probiotics as an Adjunct to Scaling and Root Planing in Nonsurgical Treatment Outcome of Generalized Chronic Periodontitis Patients: A Clinico-Microbiological Study. Int J Experiment Dent Sci 2017;6(1):6-13.

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