scholarly journals Efficacy of Oral Probiotics as an Adjunct to Scaling and Root Planing in Nonsurgical Treatment Outcome of Generalized Chronic Periodontitis Patients: A Clinico-Microbiological Study

2017 ◽  
Vol 6 (1) ◽  
pp. 6-13 ◽  
Author(s):  
Ameet Mani ◽  
Shubangi Mani ◽  
Sugandha R Saini
Keyword(s):  
Treatment Outcome ◽  
Chronic Periodontitis ◽  
Nonsurgical Treatment ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Once Daily ◽  
Microbiological Study ◽  
Root Planing ◽  
Group I ◽  
Group Ii

ABSTRACT Aim: This study aims to find out the effects of Probiotics, delivered with a lozenge for its effect on clinical and microbiological parameters in subjects with chronic periodontitis after scaling and root planing (SRP). Materials and methods: A total of 40 generalized mild to moderate chronic periodontitis subjects were finally enrolled in a double-blind, placebo-controlled, randomized clinical study. Selected subjects after SRP were randomly divided into two groups: Group I (test group) with 20 subjects receiving probiotic tablet once daily and group II (control group) receiving placebo tablets once daily. Clinical parameters and bacterial count for Aggregatibacter actinomycetemcomitans, Porphyromonas gingivalis, Prevotella intermedia, Fusobacterium nucleatum were evaluated at baseline, 2, and 4 months after the medication. Results: On comparative evaluation between the two groups, results indicated that group I (probiotic group) exhibited statistically significant reduction in both clinical and microbiological levels than group II (control group) over the entire span of the study. Conclusion: Our results proved that daily oral supplementation of probiotics could be a useful adjunct to SRP in chronic periodontitis patients. How to cite this article Mani A, Saini R, Saini SR. Efficacy of Oral Probiotics as an Adjunct to Scaling and Root Planing in Nonsurgical Treatment Outcome of Generalized Chronic Periodontitis Patients: A Clinico-Microbiological Study. Int J Experiment Dent Sci 2017;6(1):6-13.

scholarly journals Systemic Lycopene as an adjunct to Non-Surgical Periodontal Therapy in Generalized Chronic Periodontitis

2021 ◽  
Vol 12 (1) ◽  
pp. 115-119
Author(s):  
Shilpa Kamra ◽  
Amit Bhardwaj ◽  
Geetanjali Arora
Keyword(s):  
Chronic Periodontitis ◽  
Test Group ◽  
Mean Value ◽  
Control Group ◽  
P Value ◽  
Scaling And Root Planing ◽  
Once Daily ◽  
Reactive Protein ◽  
Root Planing ◽  
Promising Treatment

Aim: To evaluate the potency of systemic anti-oxidants in the non-surgical treatment of generalised chronic periodontitis. Objective: Purpose of this short term clinical study is to ascertain whether or not daily systemic supplementation of antioxidants adjunctively used after scaling and root planing (SRP) would improve clinical condition in generalised chronic periodontitis using C-reactive protein (CRP) as inflammatory markers and chronic periodontitis treatment index needs (CPTIN Index) to evaluate reduction in periodontal pockets. Results: Each group involved 10 participants with age group 30-65 years. The test group was provided with treatment with 20 mg Lycopene once daily after 24 hours of completion of scaling and root planing. The CRP value at baseline ranged from 3- 6.2 with a mean value of 4.87± 1.09. After one month of treatment, the CRP value ranges between 1.1- 4.8 with a mean value of 3.10 ± 1.05. This clearly indicates a significant decrease in CRP with t value 10.83 and >0.00 p value. The CRP value of control group at baseline ranged from 3-5.9 with a mean value of 4.58± 1.08. After one month of treatment with scaling and root planing, the CRP value ranges to 2.2- 5.4 with a mean value of 3.96 ± 1.08. This clearly indicates a significant decrease in CRP with t value 13.29 and > 0.00 p value. Conclusion: Lycopene as an antioxidant is a promising treatment modality as an adjunct to full mouth scaling. It helps to modulate oxidative stress in periodontium during periodontitis. It also leads to maintenance of periodontal health. 

scholarly journals Gingival crevicular fluid level of soluble triggering recep-tor expressed on myeloid cells-1(strem-1) in periodontal health and disease: a case-control study

2017 ◽  
Vol 5 (2) ◽  
pp. 83
Author(s):  
Surabhi Gigras ◽  
Sudhir R Patil ◽  
Veena HR ◽  
Sneha Dani
Keyword(s):  
Chronic Periodontitis ◽  
Myeloid Cells ◽  
Cell Surface Receptor ◽  
Periodontal Health ◽  
Group Iii ◽  
Root Planing ◽  
Group I ◽  
Health And Disease ◽  
Group Ii ◽  
Crevicular Fluid

Background: The Triggering Receptor Expressed On Myeloid Cells-1(TREM-1) is a cell-surface receptor of the immunoglobulin superfamily and found to be involved in the amplification of the inflammatory response to various microbial infections, including periodontal diseases.Objectives: The present study was designed to examine gingivalcrevicular fluid(GCF) levels of soluble TREM-1 (sTREM-1) levels in periodontal health and disease as well as evaluate the effect of scaling and/or root planing on the same.Methods: Based on gingival index, probing pocket depth, clinical attachment level, and radiologic parameters (bone loss), 45 subjects were initially divided into three groups- Group, I (Periodontally healthy), Group II (Gingivitis) and Group III (Chronic Periodontitis).From each of the subjects, GCF sample was collected at baseline and scaling and/or root planing was instituted in group II and group III patients. GCF samples were subsequently collected at eight-week interval. Levels of sTREM-1 in collected GCF samples were estimated using enzyme-linked immunosorbent assay.Results: The lowest GCF levels of sTREM-1 were found in periodontal health (69.50±1.8pg/ml) followed by gingivitis (257.17±79pg/ml) and chronic periodontitis (3658.14±55pg/ml) in increasing order, suggesting that levels of sTREM-1 in crevicular fluid increased with the severity of periodontal disease. sTREM-1 levels decreased significantly from baseline to the end of 8 weeks following non-surgical periodontal therapy.Conclusion: Increased GCF levels of sTREM-1 from periodontal health to disease strengthen its association with periodontal status.

scholarly journals COMPARATIVE EVALUATION OF EFFICACY OF SCALING AND ROOT PLANING WITH AND WITHOUT CHLORHEXIDINE CHIP AND DIODE LASER IN CHRONIC PERIODONTITIS PATIENTS

2021 ◽  
Vol 5 (11) ◽  
Author(s):  
Reya Shree ◽  
Varun Dahiya ◽  
Pradeep Shukla ◽  
Prerna Kataria ◽  
Mona Dagar
Keyword(s):  
Diode Laser ◽  
Chronic Periodontitis ◽  
Control Group ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Probing Pocket Depth ◽  
Root Planing ◽  
Before And After ◽  
Laser Group

Introduction: The motive of the present study is to comparatively measure the competence and effectiveness of diode laser and chlorhexidine chip as adjuncts to the scaling and root planing procedure, in patients with chronic periodontitis. Aim: To evaluate the efficacy of diode laser and chlorhexidine chip before and after scaling and root planing in the management of chronic periodontitis. The objective is to compare the efficacy of chlorhexidine chip and diode laser before and after scaling and root planning on clinical parameters. Study and design: Randomized clinical trial with split mouth design done in the Department of Periodontics and Implantology. Materials and methods: Twenty chronic periodontitis patients having a probing pocket depth of 5mm-7mm on at least one interproximal site in each quadrant of the mouth were selected in the study. After initial treatment, four sites in each patient were randomly subjected to scaling and root planing (control), chlorhexidine chip application (CHX chip group), diode laser (810 nm) decontamination (Diode laser group) or combination of both (Diode laser and chip group). All subjects received a clinical periodontal examination by single examiner who recorded all the variables by manual procedure. Clinical parameters namely Plaque index (PI), Gingival Index (GI), probing pocket depth (PPD) and clinical attachment level (CAL) were assessed at baseline, one month and three months. Results were statistically analysed using one-way ANOVA followed by Post Hoc Analysis. Results: The differences in PPD reduction and CAL gain between control group and CHX chip and combination groups were statistically significant (p<0.05) at three months, whereas, the diode laser group did not show any significant difference from the control group. Conclusion: Within the limitations in the present study, the following conclusions were derived, i.e., chlorhexidine local delivery alone or in combination with diode laser decontamination is effective in improving oral hygiene, reducing gingival inflammation, reducing probing pocket depth and improving clinical attachment levels when used as adjuncts to scaling and root planing in non-surgical periodontal therapy of patients with chronic periodontitis. Keywords: Diode laser decontamination, Local drug delivery, Scaling and root planing.

Effect of Ethanolic Extract of Carica Papaya seeds in Drug-Induced Acute Nephrotoxicity

2021 ◽  
Vol 15 (11) ◽  
pp. 2951-2953
Author(s):  
Sameer Ahmed ◽  
Muhammad Tahir ◽  
Attiya Munir ◽  
Amtul Hafeez ◽  
Sher Afghan Khan ◽  
...  
Keyword(s):  
Carica Papaya ◽  
Ethanolic Extract ◽  
Control Group ◽  
Standard Diet ◽  
Serum Urea ◽  
Once Daily ◽  
Group Iii ◽  
Group I ◽  
Papaya Seeds ◽  
Group Ii

Background: Nephrotoxicity is characterized by raised serum urea and creatinine levels and kidneys being one of the primary organs of drug concentration and excretion are vulnerable to many widely used marketed drugs, including anti-cancer drugs, antibiotics, immunosuppressants, and radio contrast agents, are nephrotoxic. Aim: To determine the nephroprotective effect of ethanolic extract of Carica papaya seeds in Aminoglycoside induced acute nephrotoxicity. Study design: Quasi Experimental study. Methodology: Thirty Sprague Dawley rats were sub divided into 3 groups i.e., I, II and III with 10 rats in each group. Group II and III were administered Aminoglycoside drug; Gentamycin in 80 mg/kg) via intraperitoneal route once daily for 5 consecutive days to induce acute nephrotoxicity. At day 6, nephrotoxicity was confirmed by measuring serum urea and creatinine. Ethanolic extract of Carica papaya seeds (1000 mg/kg) was started once daily through oral route in group III for 5 consecutive days to see the nephroprotective effects of seed extract after causing acute kidney injury. All animals were given standard diet pellets manufactured at NIH. Results: Mean serum urea and creatinine for Group I (Control Group) at day 0 were 24.90 mg/dL ± 1.633 and .750 mg/dL ± .0619 respectively. Mean serum urea and creatinine for Group II (Disease Control Group) was 81.00 mg/dL ± 1.247 and 1.980mg/dL ± .0467 at day 6th. This suggested induction of nephrotoxicity by Gentamycin. Mean serum urea and creatinine for Group III (Ethanolic Extract Treated Group) at 11 day was 72.40mg/dL± .991 and 1.680 mg/dL± .0467 after 5 days treatment with ethanolic extract of Carica papaya seeds. Conclusion: We concluded that ethanolic extract of Carica papaya seeds has significant nephroprotective effects on Aminoglycoside induced acute nephrotoxicity in rats. Keywords: COVID-19, Vaccination, Awareness and Adverse Effects

TOPICAL CHEMOTHERAPEUTIC ADJUNCTS IN NON-SURGICAL PERIODONTAL THERAPY – A RANDOMISED CONTROLLED DOUBLE BLINDED TRIAL.

2021 ◽  
Vol 5 (3) ◽  
Author(s):  
Upendra Prasad ◽  
Abhinav Deshpande ◽  
Praneeta Kamble ◽  
Abhishek Singh ◽  
Adiya Apon ◽  
...  
Keyword(s):  
Chronic Periodontitis ◽  
Comparable Efficacy ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Pocket Depth ◽  
Root Planing ◽  
Intergroup Comparison ◽  
Significant Difference ◽  
Group A ◽  
Chlorhexidine Gel

Introduction: Topical chemotherapeutic agents used in treatment of chronic periodontitis are antimicrobial agents which help in plaque control. The present study evaluates the efficacy of ornidazole gel with gold standard chlorhexidine gel when used as adjunct to scaling and root planing. Material and Methods: 90 patients diagnosed as chronic periodontitis, having pocket depth ?3 mm and in good systemic health were selected by systematic sampling method and divided in 3 groups. In all 3 groups scaling and root planing was done. In group A, Ornidazole gel application was done while in Group B Chlorhexidine gel application was done while Group C was control group. Plaque Index (PI) and Gingival Index (GI) were recorded at baseline, 1 and 3 months while Probing pocket depth (PPD) and Clinical attachment level (CAL) were recorded at baseline and 3 months. Results: PI and GI showed significant reduction in all three groups after 1 and 3 months compared to baseline. On inter group comparison, both PI and GI showed no significant difference in reduction of scores after 1 month and 3 months (p>0.05). PPD and CAL values showed statistically significant reduction after 3 months when compared to baseline values. The intergroup comparison revealed statistically significant reduction in group A and B compared to control group C (p<0.05). Conclusion: Ornidazole showed comparable efficacy as Chlorhexidine when used as adjunct to scaling and root planing for treatment of chronic periodontitis.

scholarly journals Laser Assisted Non-surgical Periodontal Therapy: A Double Blind, Randomized Clinical Trial

2017 ◽  
Vol 11 (1) ◽  
pp. 79-90 ◽  
Author(s):  
Joseph D. Everett ◽  
Jeffrey A. Rossmann ◽  
David G. Kerns ◽  
Ibtisam Al-Hashimi
Keyword(s):  
Laser Therapy ◽  
Chronic Periodontitis ◽  
Test Group ◽  
Control Group ◽  
Scaling And Root Planing ◽  
Clinical Attachment Level ◽  
Laboratory Parameters ◽  
Root Planing ◽  
Significant Difference ◽  
Attachment Level

The objective of this study was to examine potential benefits of using laser therapy for secular decontamination in conjunction with scaling and root planing in the treatment of chronic periodontitis. The study was performed on 173 teeth in 14 patients in a split-mouth design, one side received scaling and root planing followed by laser therapy using a carbon dioxide (CO2) laser with an ablative handpiece (test group); the contralateral side received scaling and root planing without laser (control group). Clinical and laboratory parameters were evaluated prior to treatment and at 3 and 6 months following therapy; clinical measurements were performed by two blinded examiners. The clinical parameters included measurement of gingival recession (REC), bleeding on probing (BOP), clinical attachment level (CAL), pocket depth (PD), furcation involvement (FUR), and tooth mobility (MOB). Laboratory testing to determine the levels of periodontal pathogens was performed using PCR techniques. The results of the study revealed statistically significant differences in clinical and laboratory parameters at 3 and 6 months after therapy for both test and control groups, but no significant difference was observed between the two groups. However, sites receiving laser therapy tended to show a greater decrease in probing depths, gain in clinical attachment level, and reduced bacterial levels. In conclusion, the overall results of the study suggest a potential benefit of using laser therapy in conjunction with scaling and root planing for the treatment of chronic periodontitis.

scholarly journals HMG-COA Reductase Inhibition by Simvastatin Reduces Neointimal Inflammation in a Rat Model of Atherosclerosis

2014 ◽  
Vol 28 (1-2) ◽  
pp. 5-9
Author(s):  
Rezina Sultana ◽  
Md Sayedur Rahman ◽  
Nargis Akhter
Keyword(s):  
Soybean Oil ◽  
Atherosclerotic Lesion ◽  
Male Rats ◽  
Control Group ◽  
Hmg Coa Reductase ◽  
Once Daily ◽  
Group I ◽  
Group Ii ◽  
Coa Reductase ◽  
Ischemic Events

Background: Inhibitors of HMG-CoA-reductase reduce cardiovascular mortality through the mechanisms yet elucidated. Most ischemic events are secondary to disruption of atherosclerotic plaques highly infiltrated by macrophages.Objectives: To study the effect of the 3-hydroxy-3-methyl-glutaryl coenzyme A (HMG-CoA)-reductase inhibitor simvastatin on the potential mechanisms involved in the recruitment of monocytic cells into the vessel wall.Methodology: This experimental study was carried out in the Laboratory of the Department of Pharmacology & Therapeutics, BSMMU, Shahbag, Dhaka, during the period from 1st July 2008 to 30th June 2009. Fifty healthy Long-Evans Norwegian male rats aged between 3-4 months and weighing between 180-200gm were randomly selected and divided into 3 groups (A, B & C). Control group A (n=10) were fed on standard rat diet for 8 weeks, Vehicle fed group B (n=10) were fed soybean oil at a dose of 1ml once daily for 8 weeks and 2% cholesterol fed group C (n=30) were fed a 2% cholesterol enriched diet (suspension of cholesterol powder in soybean oil) at a dose of 100mg/ml of 2ml once daily for 8 weeks. After 8 weeks 10 rats of each group were sacrificed and remaining 20 rats of group C were continued to the part II of the experiment and divided into two groups. Group-I (cholesterol fed control group, n=10) and Group-II (simvastatin treated group). Group-I fed 0.5ml of o.1% cholesterol enriched diet once daily to maintain atherosclerotic state & Group-II treated with 1ml of 60mg/ml simvastatin at a dose of 300mg/Kg/day along with 0.5ml of 0.1% cholesterol enriched diet. After 8 weeks all the rats of two group were sacrified. Blood collected from each rats for estimation of serum lipid profile by enzymatic methods and aorta was preserved for histopathological examination and Intima-media ratio was measured using Image-proplus software (Silva et al, 2000).Results: Simvastatin induced a significant reduction in serum lipids (p<0.001) and in atherosclerotic lesion size (p<0.001). Aortic macrophage infiltration was abolished by the treatment.Conclusions: In a rat atherosclerosis model, simvastatin diminished the neointimal inflammation and this could contribute to the stabilization of the atherosclerotic plaque. This may be an additional explanation for the reduction of acute ischemic events in patients treated with statins. DOI: http://dx.doi.org/10.3329/bjpp.v28i1-2.20073 Bangladesh J Physiol Pharmacol 2012; 28(1&2):5-9

Efficacy of subgingivally delivered atorvastatin and simvastatin as an adjunct to scaling and root planing

2015 ◽  
Vol 30 (4) ◽  
Author(s):  
Sai M. Surve ◽  
Anirudh B. Acharya ◽  
Srinath L. Thakur
Keyword(s):  
Chronic Periodontitis ◽  
Gingival Crevicular Fluid ◽  
Local Delivery ◽  
Control Group ◽  
Clinical Parameters ◽  
Scaling And Root Planing ◽  
Root Planing ◽  
Significant Difference ◽  
Group 2 ◽  
Crevicular Fluid

AbstractThe current understanding of the pathogenesis of periodontal disease has resulted in adjunctive use of various pharmacologic agents in periodontal therapy. The objective of this investigation was to assess the efficacy of atorvastatin and simvastatin (because of their pleiotropic properties) as an adjunct to dental scaling and root planing (SRP) by local delivery, i.e. placing them subgingivally, in the treatment of chronic periodontitis.Local delivery systems for atorvastatin and simvastatin were prepared in sodium alginate suspension to be administered with calcium chloride solution. Patients diagnosed with chronic periodontitis were grouped as group 1, receiving SRP only (control), group 2, receiving SRP with subgingival delivery of 1.2% simvastatin, and group 3, receiving SRP with subgingival delivery of 1.2% atorvastatin. Clinical parameters and interleukin (IL) 1α levels in the gingival crevicular fluid (GCF) were assessed.All three groups showed significant reductions in clinical parameters and IL-1α levels in the GCF (p<0.05). However, the test groups did not show any statistically significant difference when compared with control.Subgingivally delivered atorvastatin and simvastatin as an adjunct to SRP is efficacious but did not demonstrate any added benefit as compared with SRP alone.

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