Assessment of ganglion cell complex, macular thickness, and optic disc parameters in keratoconus patients

Introduction: Alzheimer’s disease (AD) is the commonest form of dementia worldwide. The modalities to diagnose AD are generally expensive and limited. Both CNS and Retina are derived from cranial neural crest, so the changes in retinal layers may reflect the changes in CNS tissue. Optical Coherence Tomography (OCT) machine can show the delicate retinal layers and is widely used in retinal disorders. The purpose of this study is to find a new biomarker to help clinicians diagnose AD by the means of retinal OCT examination. Methods: After considering the inclusion and exclusion criteria, 25 patients with mild and moderate AD and 25 normal matched subjects were enrolled in the study. OCT was done for all eyes. Central Macular thickness (CMT) and Ganglion Cell Complex (GCC) thickness were calculated. Groups were compared using SPSS 22 software. Results: Both GCC thickness and CMT were significantly decreased in patients with AD, compared to healthy age and sex matched subjects. Conclusion: Retinal changes, specifically CMT and GCC thickness, may reflect the AD process in brain. OCT may be considered as a non-invasive and inexpensive means to help diagnose the AD.

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Corneal Biomechanics, Optic Disc Morphology, and Macular Ganglion Cell Complex in Myopia

Journal of Glaucoma ◽

10.1097/ijg.0b013e3182447a17 ◽

2013 ◽

Vol 22 (5) ◽

pp. 358-362 ◽

Cited By ~ 10

Author(s):

Pei-Yao Chang ◽

Shu-Wen Chang

Keyword(s):

Ganglion Cell ◽

Optic Disc ◽

Cell Complex ◽

Corneal Biomechanics ◽

Ganglion Cell Complex

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Comparison of Structural Defects between Optic Disc and Ganglion Cell Complex in Patients with Glaucoma

Ophthalmology Research An International Journal ◽

10.9734/or/2019/v10i430114 ◽

2019 ◽

pp. 1-7

Author(s):

Ilias Georgalas ◽

Sergios Taliantzis ◽

Maria Kazaki ◽

Eva Papaconstantinou ◽

Elina Panagiotopoulou ◽

...

Keyword(s):

Optic Nerve ◽

Ganglion Cell ◽

Optic Disc ◽

Optic Nerve Head ◽

Cell Complex ◽

The Other ◽

Optic Disk ◽

Structural Defects ◽

Ganglion Cell Complex ◽

Glaucomatous Damage

Purpose: To evaluate the agreement of glaucomatous structural defects of the ganglion cell complex (GCC) detected with the spectral domain optical coherence tomography (sdOCT) with the optic nerve head alterations detected with the Heidelberg retina tomography (HRT), of glaucoma patients with ocular hypertension or open angle glaucoma. Material and Methods: Ninety patients eyes with structural glaucomatous defects were enrolled. All of them underwent imaging examination of GCC with sdOCT and the optic disk with HRT. The Cohen's kappa coefficient of agreement was used. Results: The agreement between the optic disc and GCC using the parameters of the programs analysis of the HRT, the moorfields regression analysis (MRA) and glaucoma probability score (GPS) was not significant. Instead between MRA and GPS a good agreement was calculated. Significant agreements were found between MRA and GPS on one hand and GCC on the other, considering location and length of the glaucomatous damage, while non significant agreements were found between GPS and GCC for the location and the length of the glaucomatous structural defect. Conclusions: There is no significance (Please explain further if you are referring to significance in terms of the difference, similarity or agreement) between HRT and sdOCT for the detection of the glaucomatous damage between the optic nerve head and the ganglion cell complex. Instead MRA and GCC detect comparable areas and lengths of the glaucomatous damage. On the other hand GPS records larger deficits relative to MRA and has not a significant agreement with the study of GCC.

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Possibilities of OCT Angiography for Diagnosis of Anterior Ischemic Optic Neuropathy: Parameters of the Ganglion Cell Complex, Optic Disc and Peripapillary Retina

Russian ophthalmology of children ◽

10.25276/2307-6658-2020-4-25-28 ◽

2020 ◽

pp. 25-28

Author(s):

E.E. Ioyleva ◽

◽

A.Y. Safonenko ◽

N.A. Gavrilova ◽

E.P. Andrusyakova ◽

...

Keyword(s):

Ganglion Cell ◽

Optic Disc ◽

Optic Neuropathy ◽

Cell Complex ◽

Anterior Ischemic Optic Neuropathy ◽

Oct Angiography ◽

Ganglion Cell Complex ◽

Ischemic Optic Neuropathy ◽

Correlation Relationship ◽

Spectral Oct

Purpose. Study the thickness of periapillary retina, ganglion cell complex and optic disc parameters in patients with nonarteritised anterior ischemic optic neuropathy using the spectral OCT angiography. Material and Methods. We examined 17 people (17 eyes) with unilateral non-arteritised anterior ischemic optic neuropathy (no more than 30 days from the appearance of complaints), the average age was 64.1±8.1 years. The control group consisted of 37 volunteers. All the subjects were treated with spectral OCT angiography on RTVue XR Avanti device (Optovue Inc., USA). Results. In patients with non-arteritised anterior ischemic optic neuropathy, compared to the control group, there was a statistically significant increase in the average thickness of periapillary retina nerve fiber layer from 136 to 403 µm, an increase in optic disc area and neuroretinal belt (p < 0.0001) and the absence of cupping (Cup Volume = 0). A decrease in average thickness of ganglion cell complex was found in 8 out of 17 patients, while all patients showed increases in FLV (p=0.008) and GLV (p=0.036). A direct correlation relationship between FLV (r=0.64; p<0.05) and GLV (r=0.51; p<0.05) was found, as well as a moderate negative correlation relationship between uncorrected visual acuity (r=-0.58; p<0,05), moderate direct correlation relationship between average thickness of periapillary retina nerve fiber layer and thickness of ganglion cell complex (r=0.68; p<0,05), and high inverse correlation relationship between FLV (r=-0.77; p<0,05) and GLV (r=-0.76; p<0,05). Conclusion. A comprehensive analysis of thickness of periapillary retina nerve fiber layer and parameters of ganglion cell complex using spectral OCT angiography may allow for a more accurate detection of early retinal structural abnormalities and the timely commencement of conservative therapy to preserve functional parameters. Key words: spectral OCT angiography, anterior ischemic optic neuropathy, ganglion cell complex, optic disc.

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