Comparative study of effects of gabapentin, vigabatrin and sodium valproate on psychomotor performance in healthy volunteers

In a double-blind study performed in 81 healthy volunteers, 10 mg cetirizine and 60 mg terfenadine given orally in a single administration significantly inhibited skin reactivity to histamine. Astemizole (10 mg) was completely ineffective. The inhibitory effect of cetirizine was potent and regular whereas 6/28 (21%) volunteers did not respond to terfenadine. The difference observed beween cetirizine and terfenadine might be due to differences in the metabolism of the two drugs after administration: terfenadine is rapidly and extensively metabolized whereas cetirizine is directly active without the need for biotransformation and, indeed is poorly metabolized.

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The Acute and Residual Effects of Subanesthetic Concentrations of Isoflurane/Nitrous Oxide Combinations on Cognitive and Psychomotor Performance in Healthy Volunteers

Survey of Anesthesiology ◽

10.1097/00132586-199704000-00009 ◽

1997 ◽

Vol XLI (2) ◽

pp. 77???78

Author(s):

J. P. ZACNY ◽

S. YAJNIK ◽

L. LICHTOR ◽

J. M. KLAFTA ◽

C. J. YOUNG ◽

...

Keyword(s):

Nitrous Oxide ◽

Healthy Volunteers ◽

Psychomotor Performance ◽

Residual Effects

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Self-consciousness/awareness and bladder sensations: Comparative study of overactive bladder patients and healthy volunteers

LUTS Lower Urinary Tract Symptoms ◽

10.1111/luts.12186 ◽

2017 ◽

Vol 11 (1) ◽

pp. 3-7 ◽

Cited By ~ 2

Author(s):

Desiree Vrijens ◽

Tom Marcelissen ◽

Jamie Drossaerts ◽

Rhea Heeringa ◽

Sam Degaillier ◽

...

Keyword(s):

Overactive Bladder ◽

Comparative Study ◽

Healthy Volunteers

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The post-lunch effect of regular and decaffeinated coffee on psychomotor performance: a randomized double-blind cross-over study

International Journal of Basic & Clinical Pharmacology ◽

10.18203/2319-2003.ijbcp20212924 ◽

2021 ◽

Vol 10 (8) ◽

pp. 954

Author(s):

Suganthi S. Ramachandran ◽

Vijay L. Kumar ◽

S. N. Dwivedi ◽

Vishwajeet Singh ◽

Pooja Gupta

Keyword(s):

Healthy Volunteers ◽

Psychomotor Performance ◽

Subjective Ratings ◽

Double Blind ◽

Flicker Fusion Frequency ◽

Female Ratio ◽

Cardiovascular Parameters ◽

Significant Difference ◽

Decaffeinated Coffee ◽

The Mean

Background: This study aimed to compare the effect of regular coffee and decaffeinated coffee on psychomotor performance in healthy volunteers during post-lunch period.Methods: In this randomized double-blind cross-over study, adult healthy volunteers were given hot coffee (3 g each of regular or decaffeinated coffee) during post-lunch period. Psychomotor functions (critical flicker-fusion frequency (CFF), choice reaction time (CRT) and error count in hand-steadiness test (HST)), blood pressure and heart rate were measured pre-lunch, pre-coffee (1-hour post-lunch) and 1-hour post-coffee consumption. Subjective ratings of sleepiness and mood were also assessed during post-lunch sessions.Results: The mean age of the participants (n=16) was 27.4±2.7 years with a male: female ratio of 7:9. There was no significant deterioration in psychomotor performance post-lunch when compared to pre-lunch on both the days. The mean CFF, CRT, errors committed in HST and cardiovascular parameters did not differ significantly between regular coffee and decaffeinated groups during post-lunch sessions. There was no significant difference in values of cardiovascular parameters as well as subjective ratings of sleep and mood between two groups.Conclusions: In healthy adult individuals’ consumption of both regular coffee and decaffeinated coffee during the post-lunch period did not affect psychomotor performance.

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